Skip to main content
SpringerLink
Log in

Antioxidants: Molecular Interactions Between Vitamins E And C, Biothiols and Carotenes

  • Conference paper
Signalling Mechanisms — from Transcription Factors to Oxidative Stress

Part of the book series: NATO ASI Series ((ASIH,volume 92))

  • 90 Accesses

Abstract

Antioxidants are coming under increasing scrutiny as preventive and ameliorative agents in a number of chronic degenerative conditions that have an oxidative component. A great deal of epidemiological and clinical evidence suggests that vitamin E and beta-carotene, in particular, may be beneficial.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arrio, B., Bonnefort-Rousselot, D., Catudioc, J. and Packer, L. (1993) Biochem. Mol. Biol. Int. 30:1101–1114.

    PubMed  CAS  Google Scholar 

  • Bloomfield, V.A., & T.K. Lim. (1978). Meth. Enzymol. 48: 415–494.

    Article  PubMed  CAS  Google Scholar 

  • Bonnefont-Rousselot, D., M. Gardes-Albert, S. Lepage, J. Delattre, & C. Ferradini. (1992). Radiat. Res. 132:228–236.

    Article  PubMed  CAS  Google Scholar 

  • Burkalova, Ye. B., Kuehtina, Te. E., Ol’khovskhaya, I.P., Sarycheva, I.K., Sinkiona, Ye. B., Khrapova, N.G. (1980) Biofizika 24: 989–993.

    Google Scholar 

  • Burton, G.W. and Ingold, K.U. (1981) J. Amer. Chem. Soc. 103:6472–6477.

    Article  CAS  Google Scholar 

  • Burton, G.W. and Ingold, K.U. (1989) Ann. N.Y. Acad. Sci. 570:7–22.

    Article  PubMed  CAS  Google Scholar 

  • Burton, G.W., and Ingold, K.U. (1986) Acc. Chem. Res. 19: 194–201.

    Article  CAS  Google Scholar 

  • Burton, G.W., Doba, T., Gabe, E.J., Hughes, L., Lee, F.L., Prasad, L., Ingold, K.U. (1985) J. Am. Chem. Soc. 107:7053–7065.

    Article  CAS  Google Scholar 

  • Chatelain, E., Boscoboinik, D.O., Bartoli, G.-M., Kagan, Y.E., Gey, F., Packer, L. and Azzi, A. (1993) Biochim. Biophys. Acta 1176:83–89.

    Article  PubMed  CAS  Google Scholar 

  • Dieber-Rotheneder, M., H. Puhl, G. Waeg, G. Striegl, & H. Esterbauer. (1991). J. Lipid Res. 32:1325–1332.

    PubMed  CAS  Google Scholar 

  • Esterbauer, H. M. Dieber-Rotheneder, G.Waeg, H. Puhl, & F. Tatzber. (1990b). Biochem Soc. Transact. 18:1059–1061.

    CAS  Google Scholar 

  • Esterbauer, H., Gebicki, J., Puhl, H. and Jürgens, G. (1992) Free Rad. Biol. Med. 13: 341–90.

    Article  PubMed  CAS  Google Scholar 

  • Esterbauer, H., H. Puhl, M. Dieber-Rotheneder, G. Waeg, & H. Rabl. (1991). Annals Med. 23: 573–581.

    Article  CAS  Google Scholar 

  • Esterbauer, H., J. Gebicki, H. Puhl, & G. Jürgens. (1992). Free Rad. Biol. Med. 13: 341–390.

    Article  PubMed  CAS  Google Scholar 

  • Esterbauer, H., M. Dieber-Rotheneder, G. Waeg, G. Striegl, & Jürgens, G. (1990a). Chem. Res. Toxicol. 3:77–92.

    Article  PubMed  CAS  Google Scholar 

  • Evans, H.M. and Bishop, K.S. (1922) Science 56:650–651.

    Article  PubMed  CAS  Google Scholar 

  • Gey K., Purka P. Jordan P. and Moser H (1991) Am. J. Clin. Nutr. Suppl. 53, 326S–334S.

    PubMed  CAS  Google Scholar 

  • Gey, KF (1993). Brit. Med. Bull. 49: in press.

    Google Scholar 

  • Glazer, A.N. (1990). In Meth. Enzymol., L. Packer & A.N. Glazer, Eds., Vol. 186: 161–168.

    Google Scholar 

  • Academic Press, New York, NY. Goldstein, J.L., & M.S. Brown. (1977). Ann. Rev. Biochem. 46: 897–930.

    Google Scholar 

  • Halliwell, B. and Chirico, S. (1993) Am. J. Clin. Nutr. 57: 715S-725S.

    PubMed  CAS  Google Scholar 

  • Halliwell, B. and Gutteridge, J.M.C. (1989) Free Radicals in Biology and Medicine Clarendon Press, Oxford.

    Google Scholar 

  • Hennekens C. and Eberlin K (1985) Prev. Med 14, 165–168

    Article  PubMed  CAS  Google Scholar 

  • Hiramatsu, M., R. & L. Packer. (1990). InMeth. Enzymol., L. Packer, Ed. Vol. 190: 273–280, Academic Press, New York, NY.

    Google Scholar 

  • Jialal, I., E.P. Norkus, L. Cristol., & S.M. Grundy. (1991). Biochim. Biophys. Acta. 1086: 134–138.

    PubMed  CAS  Google Scholar 

  • Kagan, V.E., E.A. Serbinova, T. Forte, G. Scita, & L. Packer. (1992b). J. Lipid Res. 33: 385–397.

    PubMed  CAS  Google Scholar 

  • Kagan, V.E., Serbinova, E.A., Forte, T., Scita, G. and Packer, L. (1992b) J. Lipid Res. 33: 385–397.

    PubMed  CAS  Google Scholar 

  • Kato A., Yamaoka M. and Tanaka A. (1985) Abura Kagaku (Jpn.), 34, 373–376.

    Google Scholar 

  • Kohlschütter, A., C. Hubner, W. Jansen, & S.G. Lindner. (1988). J. Inherited Met. Dis. 11 Suppl. 2:149–152.

    Article  Google Scholar 

  • Komiyama K., Iizuka K. Yamaoka M., Watanabe H. Tsuchiya M. and Ukezawa I. (1989) Chern Pharm Bull (Tokyo), 37, 1369–71.

    CAS  Google Scholar 

  • Kuypers, F.A., van den Berg, J.J., Schalkwijk, C., Roelofsen, B. and Op den Kamp, J.A. (1987) Biochim. Biophys. Acta 921:266–274.

    PubMed  CAS  Google Scholar 

  • Lakshman, M., K. Asher, M. Attlesey, S. Satchithanandam, I Mychkovsky, & P. Coutakis. (1989) J. Lipid Res. 30: 1545–1550.

    PubMed  CAS  Google Scholar 

  • Machlin, L.J., Ed. (1984) Handbook of Vitamins: Nutritional, Biochemical and Clinical Aspects, New York: Marcel Dekker.

    Google Scholar 

  • Marsh, D. (1980) Biochem. 19:1632–1637.

    Article  CAS  Google Scholar 

  • Mathews-Roth, M., S. Welankiwar, P. Sehgal, C. Lausen, M. Russett, And N. Krinsky. (1989) J. Nutr. 120:1205–1209.

    Google Scholar 

  • Nakano M., Siguoka K., Nakamura T and Oki T (1980)Biochim Biophys Acta, 619:274–286

    PubMed  CAS  Google Scholar 

  • Niki, E. (1987). Chem. Phys. Lipids 44:227–253.

    Article  PubMed  CAS  Google Scholar 

  • Niki, E., Kawakami, A., Saito, T., Yamamoto, Y., Tsuchiya, J., Kamiya, Y. (1986) J. Biol Chem. 260:2191–2196.

    Google Scholar 

  • Olson J., (1992) In: Lipid soluble antioxidants: Biochemistry and Clinical Applications, A. Ong and L. Packer, eds., Birkhauser Verlag, Basel, Boston, Berlin., 178–192

    Google Scholar 

  • Packer, J.E., T.R. Slater, & R.L. Willson. (1979). Nature 278: 737–738.

    Article  PubMed  CAS  Google Scholar 

  • Packer, L. (1994) Sei. Am. Sci. Med. 1: 54–63.

    CAS  Google Scholar 

  • Palozza, P. & N.I Krinsky. (1992). In: Meth. EnzymoL, L. Packer, Ed. Vol. 213: 403–420. Academic Press, New York, NY.

    Google Scholar 

  • Pentland, A.P., Morrison, A.R., Jacobs, S.C., Hruza, L.L., Hebert, J.S. and Packer, L. (1992) J. Biol. Chem. 267:15578–15584.

    PubMed  CAS  Google Scholar 

  • Riemersma, R.A., Wood, D., Macintyre, C., Elton, R., Gey, K., and Oliver, M., (1991), Lancet, 337, 1–5.

    Article  PubMed  CAS  Google Scholar 

  • Riviere, M.-E., B. Johannin, D. Gamet, V. Molitor, G.A. Peschek, & B. Arrio. (1988) In: Meth. Enzymol. 167: 691–700.

    Google Scholar 

  • Seher V and Ivanov S (1973) Fette Seifen Ans tri, 75,606–609

    Article  CAS  Google Scholar 

  • Serbinova E. and Packer L. (1994)Am. J. Nutr., (in press)

    Google Scholar 

  • Serbinova E., Khwaja S., Catudioc J., Torres Z., Kagan V. and Packer L. (1992) Nutr. Res. (Suppl.), 12, S203-S215

    Article  CAS  Google Scholar 

  • Serbinova, E., Kagan, V., Han, D. and Packer, L. (1991) Free Rad. Biol. Med. 10: 263–275.

    Article  PubMed  CAS  Google Scholar 

  • Severcan, F. and Cannistraro, S. (1990) Chem. Phys. Lipids 53:17–26.

    Article  PubMed  CAS  Google Scholar 

  • Sheppard, A.J., Pennington, J.A.T. and Weihrauch, J.L. (1993) Vitamin E in Health and Disease Ed. L. Packer and J. Fuchs. New York, NY, Marcel Dekker, Inc. pp. 9–31.

    Google Scholar 

  • Stampfer, M.J., Hennekens, C.H., Manson, J.E., Colditz, G.A., Rosner, B., and Willett, W.C. N. Engl. J. Med. 328: 1444–1449, 1993.

    Article  PubMed  CAS  Google Scholar 

  • Steinbrecher, V.P. (1987). J. Biol. Chem. 262: 3603–3608.

    PubMed  CAS  Google Scholar 

  • Suzuki, Y.J. and Packer, L. (1993) Biochem. Biophys. Res. Comm. 93: 277–283.

    Article  Google Scholar 

  • Suzuki, Y.J., Tsuchiya, M., Wassail, S.R., Choo, Y.M., Govil, G., Kagan, V.E. and Packer, L. (1993) Biochemistry 32: 10692–10699.

    Article  PubMed  CAS  Google Scholar 

  • Tatsuta T. Vitamins (Jpn) (1971), 44,185–170.

    CAS  Google Scholar 

  • Traber, M.G. and Kayden, H.J. (1984) Am. J. Clin. Nutr. 40:747–751.

    PubMed  CAS  Google Scholar 

  • Tsuchiya, M, G. Scita, H.J. Freisleben, V.E. Kagan, & L. Packer. (1992). In Meth. Enzymol., L. Packer, Ed. Vol. 213: 460–472. Academic Press, New York, NY.

    Google Scholar 

  • Tsuchiya, M., G. Scita, D.F.T. Thompson, L. Packer, V.E. Kagan, & M.A. Livrea. (1993). In Retinoids: Progress in Research and Clinical Applications, M.A. Livrea and L. Packer, Eds. pp. 525–536. Marcel Dekker, Inc. New York, NY.

    Google Scholar 

  • Zieger, R.G. (1989), J. Nutrition, 119,116–122.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of California, 94720-3200, Berkeley, CA, USA

    Lester Packer

Authors
  1. Lester Packer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Molecular and Cell Biology, University of California, 251 Life Science Addition, 94720, Berkeley, CA, USA

    Lester Packer

  2. Centre for Biomembranes and Lipid Enzymology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    Karel W. A. Wirtz

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Packer, L. (1995). Antioxidants: Molecular Interactions Between Vitamins E And C, Biothiols and Carotenes. In: Packer, L., Wirtz, K.W.A. (eds) Signalling Mechanisms — from Transcription Factors to Oxidative Stress. NATO ASI Series, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79675-3_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79675-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79677-7

  • Online ISBN: 978-3-642-79675-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation