Signal, Messenger and Trigger Molecules from Free Radical Reactions and their Control by Antioxidants

  • John M. C. Gutteridge
Conference paper
Part of the NATO ASI Series book series (volume 92)

Abstract

The element oxygen (O) exists in air as a molecule (O2) known as dioxygen or molecular oxygen. It was first isolated and characterised between 1772 to 1774 by the individual skills of the great European scientists Priestley, Lavoisier and Scheele. Dioxygen, hereafter referred to as oxygen, appeared in significant amounts on the surface of the Earth some 2.5 × 109 years ago, and geological evidence suggests that this was due to the photosynthetic activity of micro-organisms (blue-green algae).

Keywords

Peroxide Ozone Superoxide Selenium Thiol 

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References

  1. Esterbauer H, Schaur RJ, Zollner H (1991). Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Rad. Biol. Med. 11; 81–128.PubMedCrossRefGoogle Scholar
  2. Esterbauer H, Zollner H and Schaur RJ (1988). Hydroxyl alkenals: Cytotoxic products of lipid peroxidation. ISI Atlas of Sci. 1; 311–317.Google Scholar
  3. Fridovich I (1974). Superoxide dismutases. Adv. Enzymol. 41; 35–48.PubMedGoogle Scholar
  4. Gutteridge JMC (1982). Fate of oxygen radicals in extracellular fluids. Biochem. Soc. Trans. 10; 72–73.PubMedGoogle Scholar
  5. Gutteridge JMC (1986). Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides. FEBS Lett. 201; 291–295.PubMedCrossRefGoogle Scholar
  6. Gutteridge JMC (1987). The antioxidant activity of haptoglobin towards haemoglobin stimulated lipid peroxidation. Biochim. Biophys. Acta. 917; 219–223.PubMedGoogle Scholar
  7. Gutteridge JMC and Halliwell B (1988). The antioxidant proteins of extracellular fluids. In. Cellular Antioxidant Defence Mechanisms (Chow CK, ed). CRC Press, Boca Raton, pp 1–23.Google Scholar
  8. Gutteridge JMC, Paterson SK, Segal AW and Halliwell B (1981). Inhibition of lipid peroxidation by the iron-binding protein lactoferrin. Biochem. J. 199; 259–261.PubMedGoogle Scholar
  9. Gutteridge JMC and Smith A (1988). Antioxidant protection by hemopexin of haem-stimulated lipid peroxidation. Biochem. J. 256; 861–865.PubMedGoogle Scholar
  10. Gutteridge JMC and Stocks J (1976). Peroxidation of cell lipids. J. Med. Lab. Sci. 53; 281–285.Google Scholar
  11. Gutteridge JMC and Stocks H (1981). Caeruloplasmin: physiological and pathological perspectives. CRC Crit. Rev. Clin. Lab. Sci. 14; 257–329.CrossRefGoogle Scholar
  12. Haile DJ, Rouault TA, Harford JB et al (1992a). Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high affinity RNA binding. Proc. Natl. Aca. Sci. USA. 89: 11735–11739.CrossRefGoogle Scholar
  13. Haile DJ, Rouault TA, Tang CK et al (1992b) Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster. Proc. Natl. Acad. Sci. USA. 89: 7536–7540.PubMedCrossRefGoogle Scholar
  14. Halliwell B and Gutteridge JMC (1984). Lipid peroxidation, oxygen radicals, cell damage and antioxidant therapy. Lancet. 1; 1396–1397.PubMedCrossRefGoogle Scholar
  15. Halliwell B and Gutteridge JMC (1986). Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch. Biochem. Biophys. 246: 501–514.PubMedCrossRefGoogle Scholar
  16. Halliwell B, Gutteridge JMC (1989). Free Radicals in Biology and Medicine. Oxford University Press; Oxford.Google Scholar
  17. Halliwell B and Gutteridge JMC (1990). The antioxidants of human extracellular fluids. Arch. Biochem. Biophys. 280: 1–8.PubMedCrossRefGoogle Scholar
  18. Kaplan J, Jordan I and Sturrock A (1991). Regulation of the transferrin-independent iron transport system in cultured cells. J. Biol. Chem, 266: 2997–3004.PubMedGoogle Scholar
  19. Kennedy MC, Mende-Mueller L, Blondin GA and Beinert H (1992). Purification and characterisation of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein (IRE-BP). Proc. Natl. Acad. Sci. USA. 89: 11730–11734.PubMedCrossRefGoogle Scholar
  20. Kalusner RD, Rouault TA and Harford JB (1993). Regulating the fate of mRNA: The control of cellular iron metabolism. Cell. 72: 19–28.CrossRefGoogle Scholar
  21. Marklund SL, Holme E and Hellner L (1982). Superoxide dismutase in extracellular fluids. Clin. Chim. Acta. 126; 41–51.PubMedCrossRefGoogle Scholar
  22. Natarajan V, Scribner WM and Taher MM (1993). 4-Hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells. Free Rad. Biol. Med. 15: 365–375.PubMedCrossRefGoogle Scholar
  23. Saran M and Bors W (1989). Oxygen radicals acting as chemical messengers: A hypothesis. Free Rad. Res. Commun. 7: 213–220.Google Scholar
  24. Saran M and Bors W (1994). Signalling by O2− and NO: how far can either radical, or any specific reaction product, transmit a message under in vivo conditions? Chem. Biol. Interact. 90: 35–45.PubMedCrossRefGoogle Scholar
  25. Schaur RJ, Dussing G, Kink E et al (1994). The lipid peroxidation product 4-hydroxynonenal is formed by - and is able to attract-rat neutrophils in vivo. Free Rad. Res. 20: 365–373.CrossRefGoogle Scholar
  26. Vile GF and Tyrrell RM (1993). Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J. Biol. Chem. 268: 14678–14681PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • John M. C. Gutteridge
    • 1
  1. 1.Oxygen Chemistry Laboratory, Unit of Critical Care, Department of Anaesthesia and Intensive CareRoyal Brompton Hospital NHS TrustLondonUK

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