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Cap-Independent Translation in Adenovirus Infected Cells

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Cap-Independent Translation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 203))

Abstract

Adenoviruses (Ads) are DNA viruses that infect humans, animals and birds, with different serotypes displaying different tissue tropisms (Beladi 1972). Ad was originally isolated because infection results in cytopathic effects and alterations in basic cellular metabolism. The Ad genome is temporally organized into early and late transcription units that are activated before or with the onset of viral DNA replication, respectively. Six early transcription units encode products required for productive viral replication and transformation of the infected cell. Regions E1A and E1B are required for cellular transformation and transactivation of the other viral transcription units (Flint and Shenk 1989). Regions E2A and E2B are required for adenoviral DNA replication. Regions E3 and E4 are required for a variety of early viral functions, including suppression of histocompatability antigen expression (reviewed in Wold and Gooding 1991), transcriptional transactivation and regulation of nuclear to cytoplasmic transport of cellular and viral mRNAs (reviewed in Schneider and Zhang 1993). The products of the early transcription units comprise only a very minor proportion of cellular mRNA and protein synthesis, and there is no evidence for selective viral translation or inhibition of cell protein synthesis during the early part of the Ad life cycle.

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Authors and Affiliations

  1. Department of Biochemistry and Kaplan Cancer Center, New York University Medical School, New York, NY, 10016, USA

    R. J. Schneider

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  1. R. J. Schneider
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Editors and Affiliations

  1. Department of Biochemistry, Biophysics, and Genetics, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Box 172, Denver, CO, 80262, USA

    Peter Sarnow

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© 1995 Springer-Verlag Berlin Heidelberg

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Schneider, R.J. (1995). Cap-Independent Translation in Adenovirus Infected Cells. In: Sarnow, P. (eds) Cap-Independent Translation. Current Topics in Microbiology and Immunology, vol 203. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79663-0_6

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  • DOI: https://doi.org/10.1007/978-3-642-79663-0_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79665-4

  • Online ISBN: 978-3-642-79663-0

  • eBook Packages: Springer Book Archive

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