Besonderheiten der Plasminogenaktivierung von Neugeborenen mit und ohne oxidative Inaktivierung von α2-Antiplasmin

  • M. Ries
  • M. Zenker
  • J. Klinge
  • R. Rauch
  • H. Keuper
  • D. Harms
Conference paper


Die Plasminogenkonzentration und die funktionelle Aktivität sind bei Neugeborenen im Vergleich zu Erwachsenen um ca. 50% vermindert [1–5].


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ambrus CM, Ambrus JL, Choi TS, Jung O, Mirand EA, Bartfay-Szabo A (1979) The fibrino-lysin system and its relationship to disease in the newborn. Am J Pediatr Hematol Oncol 1:251–260PubMedCrossRefGoogle Scholar
  2. 2.
    Andrew M, Paes B, Milner R, Johnston M, Mitchell L, Tollefsen DM, Powers P (1987) Development of the human coagulation system in the full term infant. Blood 70:165–172PubMedGoogle Scholar
  3. 3.
    Corrigan JJ (1988) Neonatal thrombosis and the thrombolytic system: Pathophysiology and therapy. Am J Pediatr Hematol Oncol 10:83–91PubMedCrossRefGoogle Scholar
  4. 4.
    Corrigan JJ, Sleeth JJ, Jeter MA, Lox CD (1989) Newborn’s fibrinolytic mechanism: Components and plasmin generation. Am J Hematol 32:273–278PubMedCrossRefGoogle Scholar
  5. 5.
    Ekelund H, Hedner U, Nilsson IM (1970) Fibrinolysis in newborns. Acta Paediatr Scand 59:33–43PubMedCrossRefGoogle Scholar
  6. 6.
    Estelles A, Aznar J, Gilabert J, Parrilla JJ (1980) Dysfunctional plasminogen in full-term newborn. Pediatr Res 14:1180–1185PubMedCrossRefGoogle Scholar
  7. 7.
    Benavent A, Estellés A, Aznar J, Martinez-Sales V, Gilabert J, Fornas E (1984) Dysfunctional plasminogen in full term newborn — study of active site of plasmin. Thromb Haemostas 51:67–70Google Scholar
  8. 8.
    Al Hilali MM, Gilliver BE (1984) Physiological activation of plasminogen in full term newborn infants. J Clin Pathol 37:1264–1267PubMedCrossRefGoogle Scholar
  9. 9.
    Andrew M, Paes, B, Johnston M (1990) Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol 12:95–104PubMedCrossRefGoogle Scholar
  10. 10.
    Andrew M, Paes, B, Milner R, Johnston M, Mitchell L, Tollefsen DM, Castle V, Powers P (1988) Development of the human coagulation system in the healthy premature infant. Blood 72:1651–1657PubMedGoogle Scholar
  11. 11.
    Barnard DR, Simmons MA, Hathaway WE (1979). Coagulation studies in extremely premature infants. Pediatr Res 13:1330–1335PubMedCrossRefGoogle Scholar
  12. 12.
    Forestier F, Daffos F, Galactéros F, Bardakijan J, Rainaut M, Benzard Y (1986) Hematological values of 163 normal fetuses between 18 and 30 weeks of gestation. Pediatr Res 20:342–346PubMedCrossRefGoogle Scholar
  13. 13.
    Holmberg L, Henriksson P, Ekelund H, Astedt B (1974) Coagulation in the human fetus, comparison with term newborn infants. J Pediatr 85:860–864PubMedCrossRefGoogle Scholar
  14. 14.
    Jensen AH, Josso F, Zamet P, Monset-Couchard M, Minkowski A (1973) Evolution of blood clotting factor levels in premature infants during the first 10 days of life: A study of 96 cases with comparison between clinical status and blood clotting factor levels. Pediatr Res 7:638–644PubMedCrossRefGoogle Scholar
  15. 15.
    Künzer W (1961) Fetales fibrinogen. Klin Wochenschr 39:536–542CrossRefGoogle Scholar
  16. 16.
    Witt I, Müller H, Künzer W (1969) Evidence for the existence of foetal fibrinogen. Thromb Diath Haemorrh 22:101–109PubMedGoogle Scholar
  17. 17.
    Schettini F, de Mattia D, Mautone A (1972) Preprothrombin and prothrombin in full term newborns. Haemostasis 1:271–278PubMedGoogle Scholar
  18. 18.
    Saleh AA, Hirokawa S, Stowers MA, Eldridge DM, Dorey LG, Dombrowski MP, Bottoms SF, Kazzi GM, Mammen EF (1993) Effect of mode of delivery on certain parameters of neonatal hemostasis. Thromb Haemostas 69:1020Google Scholar
  19. 19.
    Suarez CR, Walenga J, Mangogna LC, Fareed J (1985) Neonatal and maternal fibrinolysis: Activation at time of birth. Am J Hematol 19:365–372PubMedCrossRefGoogle Scholar
  20. 20.
    Ekelund H (1972) Fibrinolysis in the first year of life. Acta Paediatr Scand 61:5–10PubMedCrossRefGoogle Scholar
  21. 21.
    Thorsen S, Philips M, Selmer J, Lecander I, Astedt B (1988) Kinetics of inhibition of tissue-type and urokinase-type plasminogen activator by plasminogen activator inhibitor type 1 and type 2. Eur J Biochem 175:33–39PubMedCrossRefGoogle Scholar
  22. 22.
    Stief TW, Aab A, Heimburger N (1988) Oxidative inactivation of purified α2-antiplasmin, antithrombin III, and C 1-inhibitor. Thromb Res 49:581–589PubMedCrossRefGoogle Scholar
  23. 23.
    Wiman B, Collen D (1978) On the kinetics of the reaction between human antiplasmin and plasmin. Eur J Biochem 84:573–578PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • M. Ries
  • M. Zenker
  • J. Klinge
  • R. Rauch
  • H. Keuper
  • D. Harms

There are no affiliations available

Personalised recommendations