Zusammenfassung
Die Entwicklung von F-VIII-Hemmkörpern stellt eine der schwerwiegendsten Komplikationen in der Behandlung von Hämophilie-A-Patienten dar. Wir verglichen 13 publizierte Studien zur F-VIII-Hemmkörperentwicklung [1, 4 – 9, 13 – 15, 17, 18].
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Literatur
Gill FM (1984) The natural history of factor VIII inhibitors in patients with hemophilia A. Prog Clin Biol Res 150:19 – 29
Bray GL for the Recombinate Study Group (1992) Clinical experience with recombinant Factor VIII (Recombinate) in previously untreated patients (PUPs) with hemophilia A. Abstract No. 159, XX International Congress of the World Federation of Hemophilia, Athens, Abstractbook, 83
Lusher JM, Arkin S, Abildgaard CF, Mannucci PM, Schwartz RS and the Kogenate Study Group (1992) Recombinant (r) Factor (Kogenate) in previously untreated subjects with Hemophilia A — A three year study. Abstract No. 159, XX International Congress of the World Federation of Hemophilia, Athens, Abstractbook, 94
Rasi V, Ikkala E (1990) Haemophiliacs with factor VIII inhibitors in Finland: prevalence, incidence and outcome. Br J Haematol 76:369 – 371
Lusher JM, Arkin S, Abildgaard CF, Schwartz RS and the Kogenate previously untreated patient Study Group (1993) Recombinant Factor VIII for the treatment of previously untreated patients with Hemophilia A. N Engl J Med 328:453 – 439
De Biasi R, Rocino A, Papa ML, Salerno E, Mastrullo L, De Blasi D (1994) Incidence of Factor VIII inhibitor development in Hemophilia A patients treated with less pure plasma derived concentrates. Thromb Haemost 71:544–547
Addiego J, Kasper C, Abildgaard C, Hilgartner M, Lusher J, Glader B, Aledort L (1993) Frequency of inhibitor development in haemophiliacs treated with low purity factor VIII. Lancet 342:462 – 464
Ehrenforth S, Kreuz W, Scharrer I, Linde R, Funk M, Güngör T, Krackhardt B, Kornhuber B (1992) Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs. Lancet 339:594 – 98
McMillan CW, Shapiro SS, Whitehurst D, Hoyer LW, Rao V, Lazerson J and the Hemophilia Study Group (1988) The Natural History of Factor VIII:C Inhibitors in patients with hemophilia A. A national cooperative study. Observations on the initial development of factor VIILC inhibitors. Blood 71:344–348
Lusher JM, Salzman PM and the Monoclate Study Group (1990) Viral safety and inhibitor development associated with factor VIII:C ultra-purified from plasma in haemophiliacs previously unexposed to factor VIII:C concentrate. Semin Haematol 27:1–7
Addiego J, Kasper C, Abildgaard C, Hilgartner M, Lusher M, Glader B, Aledort L (1992) Inhibitors in factor VIII deficient hemophilia: Comparison of frequency based upon treatment. Abstract No 913 ASH Anaheim Blood 80 (Suppl 1): 231a
Lusher JM, Arkin S, Kreuz W, Mannucci PM, Pearce J and the Kogenate Study Group (1991) Inhibitor (I) development in previously untreated hemophiliacs receiving rF VIII (Kogenate) — is there an increased incidence? Abstract No 217 ASH Denver, Blood 78 (Suppl 1):57 a
Sultan Y and the French Hemophilia Study Group (1992) Prevalence of inhibitors in a population of 3435 hemophilia patients in France. Thromb Haemost 67:600 – 602
Schwarzinger I, Pabinger I, Korninger C, Haschke F, Kundi M, Niessner H, Lechner K (1987) Incidence of inhibitors in patients with severe and moderate hemophilia A. Treated with factor VIII concentrates. Am J Hematol 24:241 – 245
Bray GL, Liu-Maruya S, Courter S, High K, Gomperts E and the Recombinate Study Group (1992) Experience with recombinant factor VIII (Recombinate) in previously untreated patients (PUPs) with severe hemophilia A. Abstract No 908 ASH Anaheim Blood 80 (Suppl 1): 229 a
Aledort L (1992) Proposal for a standardized protocol for PUP studies to screen for inhibitor formation (SSC on F VIII and IX of the International Society of Thrombosis and Haemostasis) Munich
Ljung R, Petrini P, Lindgren A, Tengborn L, Nilsson I (1992) Factor VIII and factor IX inhibitors in haemophiliacs. Lancet 339:1550
Lusher JM (1991) Viral safety and inhibitor development associated with monoclonal antibody-purified F VIII C. Ann Hematol 63:138 – 141
Bray G, Lee M, Buckwalter C, Lynes M, Courter S, Gomperts E for the Recombinate Study Group (1994) Use of recombinant factor VIII (Recombinate) in previously untreated patients with hemophilia A. Abstract No 107 XXI Int Congr of the World Federation of Hemophilia, Mexico City, Abstract book
Kreuz W, Martinez-Saguer I et al. (1994) Inhibitorinzidenz bei erstbehandelten Hämophilen. Aus: Scharrer I: Erstes deutsches Kogenate Symposium. Klinische Erfahrungen und Sicherheitsaspekte. Pabst, Lengerich, S 126–133
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© 1996 Springer-Verlag Berlin Heidelberg
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Kreuz, W. et al. (1996). Epidemiologie der Hemmkörperhämophilie. In: Scharrer, I., Schramm, W. (eds) 25. Hämophilie-Symposion Hamburg 1994. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79648-7_33
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DOI: https://doi.org/10.1007/978-3-642-79648-7_33
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