Skip to main content

Immuntoleranztherapie bei Kindern mit Hemmkörperhämophilie

  • Conference paper

Zusammenfassung

Die Bildung von Antikörpern gegen Faktor VIII (F VIII) stellt heute die schwerste Komplikation bei wiederholt substituierten Patienten mit Hämophilie A dar. Sie tritt bei etwa 15–33% der Patienten mit schwerer und mittelschwerer Hämophilie A auf [1–4].

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Schwarzinger I, Pabinger I, Korninger C, Haschke F, Kundi M, Niessner H, Leuchner K (1987) Incidence of inhibitors in patients with severe and moderate hemophilia A treated with factor VIII concentrates. A J Hematol 24:241 – 245

    Article  CAS  Google Scholar 

  2. Schwartz RS, Abildgaard CF, Aledort LM, Arkin S, Bloom AL, Brackmann HH, Brettler DB, Fukui H, Hilgartner MW, Inwood MJ (1990) Human recombinant DNA-derived antihemophilic factor (F VIII) in the treatment of hemophilia A. N Engl J Med 323:1799 – 1805

    Google Scholar 

  3. Rasi V, Ikkala E (1990) Haemophiliacs with factor VIII inhibitors in Finland: prevalence, incidence and outcome. Br J Haematol 76:369 – 371

    Article  PubMed  CAS  Google Scholar 

  4. Ehrenforth S, Kreuz W, Scharrer I, Linde R, Funk M, Güngör T, Krackhardt B, Kornhuber B (1992) Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs. The Lancet 339:594 – 598

    Article  CAS  Google Scholar 

  5. Kasper CK (1989) Treatment of factor VIII inhibitors. Progr Hemostas Thromb 9:57 – 86

    CAS  Google Scholar 

  6. Brackmann HH, Gormsen J (1977) Massive factor VIII in haemophiliac with factor VIII inhibitor, high responder. Lancet 2:993

    Google Scholar 

  7. Brackmann HH (1986) Induced immunotolerance in factor VIII inhibitor patients. Prog Clin Biol Res 150:181 – 185

    Google Scholar 

  8. Gomperts ED, Jordan S, Church JA, Sakai R, Lemire J (1984) Induction of tolerance to factor VIII in a child with a high-titer inhibitor: In vitro and in vivo observations. J Pediatr 104:70

    Article  PubMed  CAS  Google Scholar 

  9. Stenbjerg S, Ingerslev J, Zachariae E (1984) Factor VIII inhibitor treatment with high doses of factor VIII. Thromb Res 34:533 – 539

    Article  PubMed  CAS  Google Scholar 

  10. Scheibel E, Ingerslev J, Dalsgaard-Nielsen J, Stenbjerg S, Knudsen JB and the Danish Study Group (1987) Continuous high-dose factor VIII for the induction of immune tolerance in haemophilia A patients with high responder state: A description of eleven patients treated. Thromb Haemostas 58:1049

    CAS  Google Scholar 

  11. Sultan Y, White GC, Aronstam A, Bosser C, Brackmann HH, Brochier G, Gormsen J, Mariani G, Roberts HR, Scarabin Y, Scharrer I, Scheibel E (1986) Hemophilic patients with an inhibitor to factor VIII treated with high-dose factor VIII concentrate. Nouv Rev Fr Hematol 28:85–89

    PubMed  CAS  Google Scholar 

  12. Sjamsoedin LJM, Heijnen L, Mauser-Bunschoten EP (1981) The effect of activated Prothrombin complex concentrate (FEIBA) on joint and muscle bleeding in patients with hemophilia A and antibodies to factor VIII. A randomised double blind clinical trial. N Engl J Med 305:717 – 721

    Article  PubMed  CAS  Google Scholar 

  13. Ewing NP, Sanders NL, Dietrich SL, Kasper CK (1988) Induction of immune tolerance to factor VIII in hemophiliacs with inhibitors. JAMA 259:65 – 68

    Article  PubMed  CAS  Google Scholar 

  14. Van Leeuwen EF, Mauser-Bundschoten EP, van Dijken PJ, Kok AJ, Sjamsoedin-Visser EJM, Sixma J (1986) Disappearance of factor VIII:C antibodies in patients with haemophilia A upon frequent administration of factor VIII in intermediate or low dose. Br J Haematol 64:291–297

    Article  PubMed  Google Scholar 

  15. Rizza CR, Matthews JM (1982) Effect of frequent factor VIII replacement on the level of factor VIII antibodies in haemophiliacs. Br J Haematol 52:13 – 24

    Article  PubMed  CAS  Google Scholar 

  16. Wensley RT, Burn AM, Reading OM (1985) Induction of tolerance to factor VIII in haemophilia A with inhibitors using low-doses of human factor VIII. (Abstr) Thromb Haemsotas 54:227

    Google Scholar 

  17. Langdell RD, Wagner RH, Brinkhous KM (1953) Effect of antihaemophilic factor on one-stage-clotting test: A presumptive test for haemophilia and a simple one-stage antihaemophilic factor assay procedure. J Lab Clin Med 41:637–645

    PubMed  CAS  Google Scholar 

  18. Kasper CK, Aledort LM, Counts RB (1975) A more uniform measurement of factor VIII inhibitors. Thromb Diath Haemorrh 34:869

    Google Scholar 

  19. Ehrenforth S, Kreuz W, Scharrer I, Kornhuber B (1992b) Factor VIII inhibitors in haemophiliacs. The Lancet 340:253

    Article  CAS  Google Scholar 

  20. Lusher JM (1987) Factor VIII inhibitors. Etiology, characterisation, natural history, and management. Ann N.Y. Acad Sci 509:89 – 102

    Article  PubMed  CAS  Google Scholar 

  21. Ewing NP (1990) Induction of immune tolerance with factor VIII concentrate in patients with hemophilia A and inhibitors. In: Kasper CK (ed) Recent Advances in Hemophilia Care, Alan R Liss Inc NY, p 59 – 68

    Google Scholar 

  22. Hedner U, Glazer S (1992) Management of hemophilia patients with inhibitors. In: Coagulation disorders I 6;5:1035 – 1046

    Google Scholar 

  23. Mariani G, Ghirardini A, Bellocco R (1994) Immune tolerance in Hemophilia — Principal results from the international registry. Thromb Haemost 72:155 – 158

    PubMed  CAS  Google Scholar 

  24. Mauser-Bundschoten EP, Roosendaal G, Bruin M, van Dijken PJ (1990) Disappearance of factor VIII:C antibodies upon frequent administration of factor VIII. Folia-Haematol-Int-Mag-Klin-Morphol-Blutforsch 117(4): 533 – 537

    Google Scholar 

  25. Lusher JM, Shapiro SS, Palascak JE et al. (1980) Efficacy of prothrombin-complex concentrates in hemophiliacs with antibodies for factor VIII. A multicentral trial. N Eng J Med 303:421–425

    Article  CAS  Google Scholar 

  26. Chiller JM, Habicht GS, Weigle WO (1971) Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science 171:813 – 815

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kreuz, W. et al. (1996). Immuntoleranztherapie bei Kindern mit Hemmkörperhämophilie. In: Scharrer, I., Schramm, W. (eds) 25. Hämophilie-Symposion Hamburg 1994. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79648-7_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79648-7_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-59103-0

  • Online ISBN: 978-3-642-79648-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics