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Wechselwirkungen zwischen Angiotensin II und dem sympathischen System

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Angiotensin II — Antagonismus

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Zusammenfassung

Angiotensin II (Ang II) interagiert mit dem sympathischen System auf verschiedenen Ebenen: Es steigert die exozytotische Freisetzung von Noradrenalin aus den sympathischen Varikositäten [28], erhöht die Freisetzung von Adrenalin aus dem Nebennierenmark, was einen ganglionären Angriffspunkt von Ang II nahelegt [24], es beeinflußt die Katecholaminfreisetzung im Zentralnervensystem [27] und verstärkt die Noradrenalinwirkung an der glatten Gefäßmuskulatur [3], Der letztgenannte Effekt wird dadurch ermöglicht, daß Ang II und Noradrenalin für die glattmuskuläre Kontraktion der Gefäße denselben „Second-messenger“, Inositoltriphosphat (IP3), benutzen [16]. Die geschilderten Wechselbeziehungen zwischen Ang II und dem sympathischen System lassen eine Differenzierung zwischen prä- und postsynaptischen Effekten erkennen: Zentrale, ganglionäre und postganglionäre Wirkungen an der Varikosität von Ang II am Sympathikus stehen als präsynaptische Effekte den postganglionären postsynaptischen Wirkungen an der glatten Muskulatur gegenüber.

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Authors
  1. P. Dominiak
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  2. L. Sieroslawski
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  3. H. Brasch
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Editors and Affiliations

  1. Abteilung für Nieren- und Hochdruckkrankheiten, Med. Klinik u. Poliklinik, Universitätsklinikum, Hufelandstr. 55, D-45147, Essen, Deutschland

    Th. Philipp (Direktor) & R. F. Schäfers (Direktor) (Direktor) &  (Direktor)

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© 1996 Springer-Verlag Berlin Heidelberg

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Dominiak, P., Sieroslawski, L., Brasch, H. (1996). Wechselwirkungen zwischen Angiotensin II und dem sympathischen System. In: Philipp, T., Schäfers, R.F. (eds) Angiotensin II — Antagonismus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79645-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-79645-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-59088-0

  • Online ISBN: 978-3-642-79645-6

  • eBook Packages: Springer Book Archive

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