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The role of cytokines in the immunopathogenesis of lupus

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Book cover Systemic Lupus Erythematosus

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Abstract

Systemic lupus erythematosus is a disease characterized by B cell hyperactivity, autoantibody production and immune complex deposition in vital organs [175]. Increasing evidence indicates a critical role for T cells, particularly CD4+ cells, in driving B cell hyperactivity. For example, work in mice has shown that actions which inhibit T cell function or deplete T cells, particularly CD4+ T cells, improve disease outcome [65, 146, 160, 207]. Many laboratories have presented data which suggest that T cell-derived cytokines may play a critical role in driving B cell differentiation and hyperactivity in lupus (see below). Furthermore, much of the immunopathology in lupus is mediated by IgG autoantibodies [175], a T cell-dependent isotype.

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Authors and Affiliations

  1. Division of Rheumatology and Clinical Immunology, Department of Medicine, 21201, Baltimore, MD, USA

    Barry S. Handwerger, Violeta Rus, Ludmila da Silva & Charles S. Via

  2. Department of Microbiology and Immunology, University of Maryland School of Medicine, 21201, Baltimore, MD, USA

    Barry S. Handwerger & Charles S. Via

  3. Department of Veterans Affairs Medical Center, 21201, Baltimore, MD, USA

    Barry S. Handwerger & Charles S. Via

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  1. Barry S. Handwerger
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  1. Division d’Hématologie, Centre de Transfusion Sanguine, Hôpital Cantonal Universitaire, 25, rue Micheli-du-Crest, CH-1211, Geneva 4, Switzerland

    Peter A. Miescher

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Handwerger, B.S., Rus, V., da Silva, L., Via, C.S. (1995). The role of cytokines in the immunopathogenesis of lupus. In: Miescher, P.A. (eds) Systemic Lupus Erythematosus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79622-7_3

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