Introduction

  • Peter A. Miescher

Abstract

During the past 50 years, systemic lupus erythematosus (SLE) has been the main subject in the field of immunopathology. Each individual discovery was followed by the discovery of a multitude of related immune phenomena. Thus, the false-positive VDR reaction opened the door to additional antibodies leading to the concept of the anti-phospholipid syndrome. The demonstration of anti-nuclear antibodies led to the discovery of a cascade of antibodies against various constituents of the cell nucleus. Today’s concept of a genetic predisposition emerged with the discovery of the H2 system in mice by Snell and subsequently of the immune response genes by Benacerraf and McDevitt.

Keywords

Arthritis Dexamethasone Methotrexate Cyclosporin Cyclophosphamide 

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Peter A. Miescher
    • 1
  1. 1.Division d’Hématologic, Centre de Transfusion SanguineHôpital Cantonal UniversitaireGenève 4Suisse

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