Abstract
During the past 50 years, systemic lupus erythematosus (SLE) has been the main subject in the field of immunopathology. Each individual discovery was followed by the discovery of a multitude of related immune phenomena. Thus, the false-positive VDR reaction opened the door to additional antibodies leading to the concept of the anti-phospholipid syndrome. The demonstration of anti-nuclear antibodies led to the discovery of a cascade of antibodies against various constituents of the cell nucleus. Today’s concept of a genetic predisposition emerged with the discovery of the H2 system in mice by Snell and subsequently of the immune response genes by Benacerraf and McDevitt.
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© 1995 Springer-Verlag Berlin Heidelberg
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Miescher, P.A. (1995). Introduction. In: Miescher, P.A. (eds) Systemic Lupus Erythematosus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79622-7_1
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DOI: https://doi.org/10.1007/978-3-642-79622-7_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79624-1
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