Skip to main content

Das pathogene Potential von Interleukin-6 und/oder dessen Rezeptor bei der Entwicklung septischer Komplikationen nach Verbrennungstrauma

The pathogenetic potential of interleukin-6 and/or of its receptor in the development of postburn sepsis

  • Conference paper
Chirurgisches Forum ’95 für experimentelle und klinische Forschung

Part of the book series: Langenbecks Archiv für Chirurgie ((FORUMBAND,volume 95))

  • 30 Accesses

Zusammenfassung

Die Fortschritte bei der Behandlung des Verbrennungsschocks haben dazu geführt, daß die Sepsis zur häufigsten Todesursache nach Verbrennungstrauma wurde. Bei 50% aller Schwerverbrannten kommt es zu septischen Verläufen [2] mit einer Letalität von 35,0–76,9% [1, 2, 4]. Dabei geht die Pseudomonas-aeruginosa (Ps. aerug.)-Sepsis mit der höchsten Letalitätsrate einher [4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Araneo BA, Shelby J, Li G-Z, Ku W, Daynes RA (1993) Administration of dehydroepiandrosterone to burned mice preserves normal immunologic competence. Arch Surg 128: 318–325

    Article  PubMed  CAS  Google Scholar 

  2. Baker CC, Trunkey DD, Baker WJ (1980) A simple method of predicting severe sepsis in burn patients. Am J Surg 139: 513

    Article  PubMed  CAS  Google Scholar 

  3. Libert C, Van Bladel S, Brouckaert P, Fiers W (1991) The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice. J Immunother 10: 227–235

    Article  PubMed  CAS  Google Scholar 

  4. McManus AT, Mason ADJ, McManus WF, Pruitt BAJ (1985) Twenty-five year review of Pseudomonas aeruginosa bacteremia in a burn center. Eur J Clin Microbiol 4 (2): 219–223

    Article  PubMed  CAS  Google Scholar 

  5. Müllberg J, Schooltink H, Stoyan T, Günther M, Graeve L, Buse G, Mackiewicz A, Heinrich PC, Rose-John S (1993) The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol 23: 473–498

    Article  PubMed  Google Scholar 

  6. Shalaby MR, Waage A, Aarden L, Espevik T (1989) Endotoxin, tumor necrosis factor-alpha and interleukin 1 induce interleukin 6 production in vivo. Clin Immunol Immunopathol 53: 488–498

    Article  PubMed  CAS  Google Scholar 

  7. Suzuki H, Yasukawa K, Saito T, Anzai M, Goitsuka R, Hasegawa A, Ohsugi Y, Taga T, Kishimoto T (1991) Anti-murine IL-6 receptor antibody inhibits IL-6 effects in vivo. Immunol Lett 30: 17–21

    Article  PubMed  CAS  Google Scholar 

  8. Suzuki H, Yasukawa K, Saito T, Narazaki M, Hasegawa A, Taga T, Kishimoto T (1993) Serum soluble interleukin-6 receptor in MRL/Ipr mice is elevated with age and mediates the interleukin-6 signal. Eur J Immunol 23: 1078–1082

    Article  PubMed  CAS  Google Scholar 

  9. Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T (1989) Interleukin-6 triggers the association of its receptor with a possible signal transducer, gpl30. Cell 58: 573–581

    Article  PubMed  CAS  Google Scholar 

  10. Van Bladel S, Libert C, Fiers W (1991) Interleukin-6 enhances the expression of tumor necrosis factor receptors on hepatoma cells and hepatoeytes. Cytokine 3: 149–154

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Pallua, N., de Buhr, C., Berger, A. (1995). Das pathogene Potential von Interleukin-6 und/oder dessen Rezeptor bei der Entwicklung septischer Komplikationen nach Verbrennungstrauma. In: Beger, H.G., Hierholzer, G., Seifert, J., Hartel, W. (eds) Chirurgisches Forum ’95 für experimentelle und klinische Forschung. Langenbecks Archiv für Chirurgie, vol 95. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79621-0_98

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79621-0_98

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-59036-1

  • Online ISBN: 978-3-642-79621-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics