Zusammenfassung
Das zunehmend häufige Pankreaskarzinom ist durch eine schlechte Prognose, auch nach chirurgischer Therapie, gekennzeichnet [1]. Die Ursachen für die Aggressivität dieses Tumors sind weitgehend ungeklärt. In der Vergangenheit wurde durch zahlreiche Studien die Bedeutung von Wachstumsfaktoren für die maligne Transformation und Progression des Pankreaskarzinoms nachgewiesen [2].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Gudjonsson B (1987) Cancer of the pancreas. 50 years of surgery. Cancer 60: 2284–2303
Korc M, Chandrasekar B, Yamanaka Y, Friess H, Büchler M, Beger HG (1992) Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and tansforming growth factor alpha. J Clin Invest 90: 1352–1360
Daughaday WH, Rotwein P (1989) Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocrine Rev 10: 68–91
Werner H, Woloschak M, Stannard B, Shen-Or Z, Roberts Jr CT, Le Roith D (1991) The insulin-like growth factor I receptor: molecular biology, heterogeneity, and regulation. In: Le Roith D (ed) Insulin-like growth factors: molecular and cellular aspects. pp 17–48, Boca Raton, CRC Press
Macaulay VM (1992) Insulin-like growth factors and cancer. Br J Cancer 65: 311–320
Hermanek P, Sobin LH (1989) TNM Classification of malignant tumours/UICC, international union against cancer. p 65 New York, Springer Verlag, 1987
Ullrich A, Berman CH, Dull TH, Gray A, Lee JM (1984) Isolation of the human insulin-like growth factor I gene using a single synthetic probe. EMBO J 3: 361–364
Ullrich A, Gray A, Tarn AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, Jacobs S, Francke U, Ramachandran J, Fujita-Yamogushi Y (1986) Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specifity. EMBO J 5. 2503–2512
Mossmann PB, Young LL (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 49–53
Raitano AB, Scuderi P, Korc M (1990) Binding and biological effects of tumor necrosis factor and gamma interferon in human pancreatic Carcinoma cells. Pancreas 5: 267–277
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Bergmann, U., Funatomi, H., Gansauge, F., Beger, H.G., Korc, M. (1995). Der Insulin-like growth factor-I ist ein autokriner Wachstumsfaktor beim humanen Pankreaskarzinom. In: Beger, H.G., Hierholzer, G., Seifert, J., Hartel, W. (eds) Chirurgisches Forum ’95 für experimentelle und klinische Forschung. Langenbecks Archiv für Chirurgie, vol 95. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79621-0_56
Download citation
DOI: https://doi.org/10.1007/978-3-642-79621-0_56
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-59036-1
Online ISBN: 978-3-642-79621-0
eBook Packages: Springer Book Archive