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Epstein-Barr-Virusinfektionen

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Book cover HNO Praxis Heute

Part of the book series: HNO Praxis Heute ((HNO,volume 15))

Zusammenfassung

Das Epstein-Barr-Virus (EBV) gehört neben dem Herpes-simplex- (HSV), dem Varicella-Zoster-(VZV), dem Zytomegalievirus (CMV) und den humanen Herpesviren Typ 6 (HHV 6) und Typ 7 (HHV 7) zur Gruppe der menschlichen Herpesviren. EBV wurde erst 1964 mit dem Elektronenmikroskop in Tumorzellen des endemischen Burkitt-Lymphoms (BL) entdeckt (Epstein et al. 1964), wenige Jahre später gelang dem Ehepaar Gertrude und Werner Henle der Nachweis, daß EBV der Erreger der infektiösen Mononukleose ist: Ein Mitarbeiter entwickelte bei Laborar-beiten die Symptome einer Mononukleose, in seinem Blut fand sich eine Serokonversion von EBV-Antikörpern, aus peripheren Lymphozyten des Patienten ließ sich eine spontane (EBV-positive) B-Zellinie etablieren (Henle et al. 1968). Diese Beobachtungen wurden später von mehreren Arbeitsgruppen bestätigt (Evans 1974). Die klinische Symptomatik der infektiösen Mononukleose (Fieber, Lymphadenopathie, Angina, Organomegalie, Exanthem) wurde bereits vor über 100 Jahren unabhängig von-einander durch die 2 Forscher Filatow (1885) und Pfeiffer (1889) beschrieben. Pfeiffer nannte die Erkrankung Drüsenfieber. 1920 wurde von Sprunt u. Evans die heute allgemein übliche Bezeichnung infektiöse Mononukleose eingeführt.

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Authors
  1. V. Schuster
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Editors and Affiliations

  1. Universitätsstraße 34, D-35037, Marburg/Lahn, Deutschland

    Horst Ganz

  2. Universitätsklinik und Poliklinik für HNO-Kranke, D-66421, Homburg/Saar, Deutschland

    Walter Schätzle

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© 1995 Springer-Verlag Berlin Heidelberg

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Schuster, V. (1995). Epstein-Barr-Virusinfektionen. In: Ganz, H., Schätzle, W. (eds) HNO Praxis Heute. HNO Praxis Heute, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79615-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-79615-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79616-6

  • Online ISBN: 978-3-642-79615-9

  • eBook Packages: Springer Book Archive

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