Follicular Dendritic Cells Initiate and Maintain Infection of the Germinal Centers by Human Immunodeficiency Virus

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 201)


Since the discovery of the human immunodeficiency virus type 1 (HIV-1) as the cause of the acquired immunodeficiency syndrome (AIDS), careful attention has been paid to the preference of the virus for specific cells. However, the preference of HIV-1 for specific host tissues or tissue compartments such as germinal centers (GC) of the lymphoid tissue was often overlooked. Application of electronmicroscopic, immunohistochemical, and nucleic acid hybridization techniques to the study of lymphoid tissues led to the demonstration that GC are infected by HIV-1 and improved our understanding of the pathogenesis of AIDS.


Human Immunodeficiency Virus Germinal Center Acquire Immune Deficiency Syndrome Simian Immunodeficiency Virus Follicular Dendritic Cell 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Bernhard-Nocht Institute for Tropical MedicineHamburgGermany

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