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Follicular Dendritic Cells Initiate and Maintain Infection of the Germinal Centers by Human Immunodeficiency Virus

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An Antigen Depository of the Immune System: Follicular Dendritic Cells

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 201))

Abstract

Since the discovery of the human immunodeficiency virus type 1 (HIV-1) as the cause of the acquired immunodeficiency syndrome (AIDS), careful attention has been paid to the preference of the virus for specific cells. However, the preference of HIV-1 for specific host tissues or tissue compartments such as germinal centers (GC) of the lymphoid tissue was often overlooked. Application of electronmicroscopic, immunohistochemical, and nucleic acid hybridization techniques to the study of lymphoid tissues led to the demonstration that GC are infected by HIV-1 and improved our understanding of the pathogenesis of AIDS.

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  1. Bernhard-Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, 20359, Hamburg, Germany

    K. Tenner-Racz & P. Racz

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  1. K. Tenner-Racz
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  1. Glaxo Institute for Immunology, 14, Chemin des Aulx, 1228, Plan-les-Ouates Geneva, Switzerland

    Marie H. Kosco-Vilbois

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Tenner-Racz, K., Racz, P. (1995). Follicular Dendritic Cells Initiate and Maintain Infection of the Germinal Centers by Human Immunodeficiency Virus. In: Kosco-Vilbois, M.H. (eds) An Antigen Depository of the Immune System: Follicular Dendritic Cells. Current Topics in Microbiology and Immunology, vol 201. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79603-6_9

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