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Murine Follicular Dendritic Cells: Accessory Activities In Vitro

Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 201)

Abstract

Follicular dendritic cells (FDC) are accessory cells found in association with B lymphocytes in the follicles of stimulated secondary lymphoid tissues. Accessory cells are known to collaborate with lymphocytes and enable them to carry out their essential functions. FDC present antigen (Ag) to B cells and facilitate B cell functions; they may be thought of as B cell-associated accessory cells. In contrast, other dendritic cells, including Langerhans cells, interdigitating cells, and veiled cells, interact primarily with T lymphocytes. These dendritic accessory cells, collectively referred to as dendritic cells (DC) in vitro, present antigen to T cells and may be thought of as T cell-associated accessory cells (TEW et al. 1992a). Data supporting the accessory activities of most accessory cells, such as DC and macrophages, have been collected using in vitro experimentation. In contrast, most of the data available on FDC has been collected using in vivo models. We have reviewed these in vivo data on murine FDC in a number of recent articles.

Keywords

Human Immunodeficiency Virus Germinal Center Drain Lymph Node Supernatant Fluid Accessory Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Department of Microbiology/Immunology, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA
  2. 2.Anatomy Division of Immunobiology, Medical College of VirginiaVirginia Commonwealth UniversityRichmondUSA

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