Role of Follicular Dendritic Cells in the Regulation of B Cell Proliferation

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 201)


Within secondary lymphoid organs, B and T lymphocytes are not randomly distributed but they specifically inhabit highly organized regions that contain areas where B and T cells are largely segregated and other areas where different populations of cells can interact and differentiate (Thorbecke et al. 1962). Specifically, in lymph nodes and tonsils, the majority of B cells localize to follicles, whereas most T cells are found in the paracortex (Nieuwenhuis and Ford 1976). Following initial entrance into the interfollicular areas of secondary lymphoid tissues, it is not known what drives B cells to localize to follicles; however, the formation of follicles is an antigen (Ag)-driven process that requires the presence and participation of T lymphocytes.


Hairy Cell Leukemia Follicular Dendritic Cell Interfollicular Area Stimulate Tyrosine Phosphorylation Staphylococcus Aureus Cowan 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Department of MedicineHarvard Medical SchoolBostonUSA

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