Mechanism of Immune Complex Trapping by Follicular Dendritic Cells

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 201)


The follicular dendritic cell (FDC) is a major constituent of the microenvironment of the lymphoid follicle. FDC have the characteristic and unique property of binding antigens in the form of antigen-antibody complexes and retaining these complexes, without ingestion, for long periods of time. The presence of antigen-antibody complexes, also called immune complexes, on FDC is believed to play a crucial role in the development of B cell memory and the affinity maturation of the antibody response against T cell-dependent antigens.


Immune Complex Germinal Center Complement Receptor Lymphoid Follicle Follicular Dendritic Cell 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Department of Cell Biology and ImmunologyVrije UniversityAmsterdamThe Netherlands
  2. 2.Department of Molecular Immunology, Institute of Development, Aging and CancerTohoku UniversityAoka-ku, SendaiJapan

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