Mechanism of Immune Complex Trapping by Follicular Dendritic Cells

  • T. K. Van den Berg
  • K. Yoshida
  • C. D. Dijkstra
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 201)

Abstract

The follicular dendritic cell (FDC) is a major constituent of the microenvironment of the lymphoid follicle. FDC have the characteristic and unique property of binding antigens in the form of antigen-antibody complexes and retaining these complexes, without ingestion, for long periods of time. The presence of antigen-antibody complexes, also called immune complexes, on FDC is believed to play a crucial role in the development of B cell memory and the affinity maturation of the antibody response against T cell-dependent antigens.

Keywords

Immune Complex Germinal Center Complement Receptor Lymphoid Follicle Follicular Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • T. K. Van den Berg
    • 1
  • K. Yoshida
    • 2
  • C. D. Dijkstra
    • 1
  1. 1.Department of Cell Biology and ImmunologyVrije UniversityAmsterdamThe Netherlands
  2. 2.Department of Molecular Immunology, Institute of Development, Aging and CancerTohoku UniversityAoka-ku, SendaiJapan

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