Follicular Dendritic Cells in Malignant Lymphomas

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 201)


The malignant lymphomas now known as Hodgkin’s disease were first described by Thomas Hodgkin in 1832. This disease is characterized by the presence of large, multinucleate cells, called Reed-Sternberg cells, which are scattered irregularly throughout Hodgkin’s infiltrates. Intermingled with the Reed-Sternberg cells is a mixed population of lymphocytes, histiocytes, eosinophils, plasma cells, and neutrophils. Histological subclassification of Hodgkin’s disease relies principally on variations in the proportions of lymphocytes and histiocytes. Thus, the lymphoma is subdivided into four types: lymphocyte predominant including the nodular paragranuloma, nodular sclerosis, mixed cellularity, and lymphocyte depleted (Lukes and Butler 1966). An estimated 4 new patients with Hodgkin’s disease per 100 000 population will be detected yearly. By chemotherapy and/or radiation approximately 75% of patients with Hodgkin’s disease can be cured.


Malignant Lymphoma Follicular Dendritic Cell Secondary Follicle Thyroid Lymphoma Follicular Dendritic Cell Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Medizinische KlinikRuhr-Universität Bochum, KnappschaftskrankenhausBochumGermany

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