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Transcriptional Regulation of the Adenovirus E1A Gene

  • Chapter
The Molecular Repertoire of Adenoviruses III

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 199/3))

Abstract

Two distinct classes of the regulatory sequences have been identified in eukaryotic transcription systems. Promoter sequences are located close to the transcription initiation site, and enhancer sequences can be located far upstream or downstream from the initiation site. Most of the enhancer consists of multiple DNA-binding sites for proteins which act either synergistically or antagonistically to modulate transcriptional activity (Johnson and McKnight 1989; Mitchell and Tjian 1989). The 72-base pair (bp) repeats of the simian virus 40 (SV40) early promoter/enhancer region constitute one of the best-characterized enhancer elements (Herr and Clarke 1986; Zenke et al. 1986; Ondek et al. 1988). The region is composed of a number of modular units, and the combined action of these different units determines the degree of enhancer activity in different cell types. Promoter sequences include the TATA box and initiation sites of transcription, which are involved in the positioning of the transcription initiation site. Promoters of house-keeping genes contain GC-rich sequences and an initiator element instead of the TATA box. These cis-acting elements operate by interacting with specific DNA-binding proteins. Therefore, an understanding of the mechanisms operational in transcriptional regulation of eukaryotic genes entails unravelling the mechanisms controlling the activity of these DNA-binding proteins (McKnight and Yamamoto 1992).

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  1. Department of Molecular Biology, Cancer Research Institute, School of Medicine, Sapporo Medical University, S-1, W-17, Chuo-ku, Sapporo 060, Japan

    K. Yoshida, F. Higashino & K. Fujinaga

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  1. Institut für Genetik, Universität zu Köln, Weyertal 121, 50931, Köln, Germany

    Walter Doerfler  & Petra Böhm  & 

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Yoshida, K., Higashino, F., Fujinaga, K. (1995). Transcriptional Regulation of the Adenovirus E1A Gene. In: Doerfler, W., Böhm, P. (eds) The Molecular Repertoire of Adenoviruses III. Current Topics in Microbiology and Immunology, vol 199/3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79586-2_6

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