Adenovirus E1A: Transcription Regulation and Alteration of Cell Growth Control
The small DNA tumor viruses, which include the adenovirus, Polyomavirus, and papillomavirus groups, have provided enormously valuable model systems with which to study complex events such as RNA processing, transcriptional regulation, and DNA replication, to name but a few examples. In addition, given the fact that these viruses also possess oncogenic activity under certain circumstances and indeed that the papillomaviruses are a significant cause of human cancer, these viruses have also provided insights into the mechanisms of cell growth control. A major advance in the understanding of viral oncogenesis came with the realization that a protein previously identified as an E1A-binding protein was actually the product of the retinoblastoma tumor suppressor gene (Whyte et al. 1988). The rapid subsequent finding that each of the DNA tumor viruses encoded proteins that bound to the Rb protein demonstrated the general nature of this event. The importance of these findings was immediately obvious: the physical interaction of oncogenic viral proteins with a key tumor suppressor protein provided a mechanistic view for the oncogenic capacity of these viruses. Nevertheless, the precise molecular consequence of these events were left unclear.
KeywordsPolypeptide Beach Stein Thymidine Kato
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