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Model Systems for Studying the Effects of Adenovirus E3 Genes on Virulence In Vivo

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Book cover The Molecular Repertoire of Adenoviruses III

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 199/3))

Abstract

Adenoviruses (Ad) are important pathogens in a variety of species. In humans, Ad are most commonly recognized in the respiratory tract and conjunctiva. However, several members of this large family of viruses can cause disease in the gastrointestinal tract, while others infect the urinary tract, liver, and central nervous system (Horwitz 1990b). In dogs, a canine Ad is a major cause of hepatitis, and the murine adenovirus type 1 (MAV-1) can cause multiorgan disease in the mouse (Ishibashi and Yasue 1984). However, the Ad that infect each species are sufficiently different that they do not cross into distantly related species. For example, human Ad replicate poorly in mice or murine tissue culture. There are 49 distinct serotypes that can infect humans, but the majority of Ad disease is caused by approximately one third of this number (Schnurr and Dondero 1993; Hierholzer et al. 1988). Ad are classified into six groups (A-F) based on GC content and genetic relatedness of their DNA, oncogenicity in rodents, and ability to agglutinate red blood cells of different species (Horwitz 1990a). The organ targeted for disease is often related to serotype, such that Ad7 causes pneumonia, Ad2 upper respiratory tract disease, Ad40 and Ad41 cause diarrhea, Ad11 is associated with hemorrhagic cystitis, and Ad34 and Ad35 are often found in the urinary tract of immunosuppressed patients (Horwitz 1990b). However, the reason for tissue-specific damage in relationship to serotype is unknown.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    M. S. Horwitz, J. Tufariello & G. Fejer

  2. Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    M. S. Horwitz

  3. Department of Pediatrics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    M. S. Horwitz

  4. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Building 4, Room 229, Bethesda, MD, 20892, USA

    A. Grunhaus

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  1. M. S. Horwitz
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  2. J. Tufariello
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  3. A. Grunhaus
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  4. G. Fejer
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Editors and Affiliations

  1. Institut für Genetik, Universität zu Köln, Weyertal 121, 50931, Köln, Germany

    Walter Doerfler  & Petra Böhm  & 

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© 1995 Springer-Verlag Berlin Heidelberg

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Horwitz, M.S., Tufariello, J., Grunhaus, A., Fejer, G. (1995). Model Systems for Studying the Effects of Adenovirus E3 Genes on Virulence In Vivo. In: Doerfler, W., Böhm, P. (eds) The Molecular Repertoire of Adenoviruses III. Current Topics in Microbiology and Immunology, vol 199/3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79586-2_10

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  • DOI: https://doi.org/10.1007/978-3-642-79586-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

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