Model-Based Adaptive Control of Volatile Anesthetics by Quantitative EEG

  • H. Schwilden
  • J. Schüttler


Automatic feedback control of the delivery of volatile anesthetic agents has been realized in the past using inspired concentrations as well as expired concentrations (see D.R. Westenskow, this volume, pp 155–157) as feedback signal. These approaches used a proportional-integral-derivative (PID) controller for feedback control of the volatile anesthetic agents. This paper deals with a model-based adaptive feedback control system of the delivery of volatile anesthetics using the EEG as the pharmacodynamic response variable to be controlled. Specifically, we used the median EEG frequency.


Nitrous Oxide Minimum Alveolar Concentration Volatile Agent Isoflurane Concentration Volatile Anesthetic Agent 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • H. Schwilden
  • J. Schüttler

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