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Thiazide Diuretics

  • Chapter
Diuretics

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 117))

Abstract

Thiazide diuretics have been in existence for more than 3 decades. They are benzothiadiazines or analogs and derivatives of the carbonic anhydrase–inhibiting sulfonamides. Their synthesis was spawned by a search for diuretics capable of promoting renal excretion of the chloride anion (instead of bicarbonate) with sodium. Thus, the “thiazide” effect is synonymous with the “saliuretic” effect as opposed simply to a natriuretic effect with bicarbonate being the predominant accompanying anion. One reason for the attractiveness of the use of these diuretics in humans was that they did not contain heavy metals and thus were less toxic than the mercury-containing diuretics in use at that time. Thiazides are currently used in the treatment of a wide variety of conditions including hypertension, edema, nephrolithiasis and diabetes insipidus.

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Authors
  1. H. Velázquez
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  2. H. Knauf
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  3. E. Mutscler
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Editors and Affiliations

  1. Physiologisches Institut, der Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 7, D-79104, Freiburg, Germany

    Rainer F. Greger

  2. Medizinische Klinik I Gastroenterologie-Kardiologie-Nephrologie, St. Bernward Krankenhaus Hildesheim, Treibestr. 9, D-31134, Hildesheim, Germany

    H. Knauf

  3. Pharmakologisches Institut für Naturwissenschaftler, Biozentrum Niederursel, Gebäude N 260, Marie-Curie-Str. 9, D-64271, Frankfurt, Germany

    E. Mutschler

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Velázquez, H., Knauf, H., Mutscler, E. (1995). Thiazide Diuretics. In: Greger, R.F., Knauf, H., Mutschler, E. (eds) Diuretics. Handbook of Experimental Pharmacology, vol 117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79565-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-79565-7_8

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