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Diuretics pp 67–114Cite as

Basic Concepts of Renal Physiology

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 117))

Abstract

The most obvious function of the kidney is the excretion of xenobiotics, excessive electrolytes and trace elements, and unnecessary and/or harmless metabolic products such as uric acid, urea and ammonia. Through its excretory function, the kidney plays a pivotal role in the regulation of volume and ion composition of the body fluids. For instance, it participates in the regulation of K+, Na+, CI–, HCO–, Ca2+, Mg2+ and HPO2.– content of the body and thus influences intracellular fluid, extra cellular fluid, blood pressure, acid–base balance, mineral metabolism, etc. Accordingly, the kidney is the target of various hormones. Furthermore, the kidney releases or activates hormones itself, such as erythropoietin, calcitriol [1,25–(OH)2D3], angiotensin, prostaglandins and kinins. The kidney also carries out several important metabolic functions, such as gluconeogenesis, degradation of fatty acids and inactivation of hormones.

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Authors
  1. F. Lang
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  2. A. Busch
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Editors and Affiliations

  1. Physiologisches Institut, der Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Str. 7, D-79104, Freiburg, Germany

    Rainer F. Greger

  2. Medizinische Klinik I Gastroenterologie-Kardiologie-Nephrologie, St. Bernward Krankenhaus Hildesheim, Treibestr. 9, D-31134, Hildesheim, Germany

    H. Knauf

  3. Pharmakologisches Institut für Naturwissenschaftler, Biozentrum Niederursel, Gebäude N 260, Marie-Curie-Str. 9, D-64271, Frankfurt, Germany

    E. Mutschler

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Lang, F., Busch, A. (1995). Basic Concepts of Renal Physiology. In: Greger, R.F., Knauf, H., Mutschler, E. (eds) Diuretics. Handbook of Experimental Pharmacology, vol 117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79565-7_2

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