Abstract
Osmotic diuretics are freely filterable, low molecular weight substances that due to their limited reabsorption and small size create an osmotic force in the tubular fluid sufficient to retard the reabsorption of fluids and solutes (notably NaCl) along the nephron. Thus, osmotic diuresis results in urinary loss of water and sodium.
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Better, O.S., Rubinstein, I., Winaver, J. (1995). Osmotic Diuretics: Mannitol. In: Greger, R.F., Knauf, H., Mutschler, E. (eds) Diuretics. Handbook of Experimental Pharmacology, vol 117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79565-7_12
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