Immediate-early genes and opioid peptides
Cellular stimulation causes the rapid appearance of proteins in the nucleus which function as signal-regulated transcription factors converting membrane events into long-term changes in gene expression. These transcription factors are the products of a variety of immediate early genes (IEG). One important group of these signal- regulated transcription factors are the BZip proteins which contain each a basic (B) and a leucine zipper (Zip) domain that are required for DNA binding and dimerization, respectively.
KeywordsDopamine Nicotine Serotonin Glucocorticoid Haloperidol
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