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A novel face of immediate-early genes: transcriptional operations dominated by c-Jun and Jun D proteins in neurons following axotomy and during regenerative efforts

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Immediate-Early Genes in the Central Nervous System

Abstract

The investigation of immediate-early genes (IEGs) in neurons and glial cells represents a new research area in neurobiology. IEGs are rapidly expressed by transsynaptic stimulation or transmembranous information transfer. A substantial number of IEGs encode for transcription factors (TF) which are involved in the control of gene transcription. The early appearance of TF offers a new access to elucidate the link between intentional stimuli and neuroplastic-reactive responses of neurons via alterations of protein synthesis. The expression of IEG encoded TF can be visualized by immunocytochemistry on the protein level (Herdegen et al. 1991a; Hunt et al. 1987; Kovary and Bravo 1991a,b; Morgan et al. 1987) or by in situ hybridization on the mRNA level (Cole et al. 1989; Wisden et al. 1990).

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Authors and Affiliations

  1. II. Institute of Physiology, University Heidelberg, Im Neuenheimer Feld 326, 69120, Heidelberg, Germany

    T. Herdegen, S. Brecht, C. E. Fiallos-Estrada, H. Wickert, F. Gillardon, S. Voss & M. Zimmermann

  2. Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ, 08543, USA

    R. Bravo

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  1. T. Herdegen
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  1. Max-Planck-Institut für Psychiatrie Klinisches Institut, Klinische Neuropharmakologie, Kraepelinstr. 2-10, D-80804, München, Germany

    T. R. Tölle , J. Schadrack  & W. Zieglgänsberger ,  & 

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Dedicated to Prof. Dr. M. Zimmermann on the occasion of his 60th birthday.

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Herdegen, T. et al. (1995). A novel face of immediate-early genes: transcriptional operations dominated by c-Jun and Jun D proteins in neurons following axotomy and during regenerative efforts. In: Tölle, T.R., Schadrack, J., Zieglgänsberger, W. (eds) Immediate-Early Genes in the Central Nervous System. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79562-6_5

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