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Molecular Mechanisms of Membrane Fusion

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Book cover Trafficking of Intracellular Membranes:

Part of the book series: NATO ASI Series ((ASIH,volume 91))

Abstract

A crucial step in the trafficking of intracellular membranes is membrane fusion. Endocytotic vesicles or phagosomes form via fusion of the apposed exoplasmic leaflets of the invaginated plasma membrane. The endocytotic vesicles are then thought to fuse with endosomes. Later in the endocytotic pathway, endosomes and phagosomes eventually fuse with lysosomes, in a process involving the interaction and fusion of the cytoplasmic leaflets of their membranes. Following endocytosis, receptor-containing vesicles undergo a “fission” or “budding” process to facilitate the transport of receptors back to the plasma membrane. This budding involves the interaction and fusion of the membrane leaflets facing the lumen of the flaccid vesicle. Likewise, in the Golgi apparatus, transport vesicles are thought to bud off from one compartment and fuse with the next one along the cis, medial and trans regions of the organelle.

This chapter is dedicated, with gratitude, to my father, Prof. Orhan Düzgüneş

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Authors and Affiliations

  1. Department of Microbiology, University of the Pacific, 2155 Webster Street, San Francisco, CA, 94115, USA

    Nejat Düzgüneş§

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  1. Nejat Düzgüneş§
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Editors and Affiliations

  1. Departamento de Bioquimica, Universidade de Coimbra, 3049, Coimbra, Portugal

    Maria C. Pedroso De Lima

  2. Department of Microbiology, University of the Pacific, San Francisco, CA, 94115, USA

    Nejat Düzgüneş

  3. Department of Physiological Chemistry, University of Groningen, 9712 KZ, Groningen, The Netherlands

    Dick Hoekstra

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Düzgüneş§, N. (1995). Molecular Mechanisms of Membrane Fusion. In: De Lima, M.C.P., Düzgüneş, N., Hoekstra, D. (eds) Trafficking of Intracellular Membranes:. NATO ASI Series, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79547-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-79547-3_7

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  • Online ISBN: 978-3-642-79547-3

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