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Trafficking of Intracellular Membranes: pp 303–315Cite as

Control of Intracellular Free Calcium in Neurons and Endocrine Cells

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Part of the book series: NATO ASI Series ((ASIH,volume 91))

Abstract

Intracellular free calcium concentrations in both neurons and endocrine cells are regulated by transporters and ion channels present either in the cell membrane or in the membrane of intracellular organelles. Low intracellular free Ca2+ levels in resting cells are maintained by active Ca2+ extrusion from the cytoplasm into the extracellular space via the Na+/Ca2+-exchanger and the plasma membrane Ca2+-ATPase (PMCA), as well as Ca2+ uptake from the cytoplasm into various intracellular compartments. Sequestration by intracellular compartments is accomplished by uni- and antiporter systems present in mitochondria or secretory granules and a family of endoplasmic and sarcoplasmic reticulum Ca2+-ATPases termed SERCA. Upon cell stimulation extracellular Ca2+ may enter the cell via voltage operated (VOCS), receptor operated (ROCS) or second messenger operated (SMOCS) calcium channels. An increase of cytosolic free Ca2+ may also be caused by Ca2+ release from intracellular compartments by diffusible second messengers activating IP3 or ryanodine receptor calcium channels.

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Author information

Authors and Affiliations

  1. Natural and Medical Science Institute, University of Tübingen in Reutlingen, 72762, Reutlingen, Germany

    Karl Josef Föhr, Artur Mayerhofer & Manfred Gratzl

  2. Division of Neuroscience, Oregon Regional Primate Research Center, Beaverton, USA

    Artur Mayerhofer

  3. Department of Anatomy and Cell Biology, University of Ulm, 89069, Ulm, Germany

    Manfred Gratzl

Authors
  1. Karl Josef Föhr
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  2. Artur Mayerhofer
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  3. Manfred Gratzl
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Editor information

Editors and Affiliations

  1. Departamento de Bioquimica, Universidade de Coimbra, 3049, Coimbra, Portugal

    Maria C. Pedroso De Lima

  2. Department of Microbiology, University of the Pacific, San Francisco, CA, 94115, USA

    Nejat Düzgüneş

  3. Department of Physiological Chemistry, University of Groningen, 9712 KZ, Groningen, The Netherlands

    Dick Hoekstra

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© 1995 Springer-Verlag Berlin Heidelberg

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Föhr, K.J., Mayerhofer, A., Gratzl, M. (1995). Control of Intracellular Free Calcium in Neurons and Endocrine Cells. In: De Lima, M.C.P., Düzgüneş, N., Hoekstra, D. (eds) Trafficking of Intracellular Membranes:. NATO ASI Series, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79547-3_19

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  • DOI: https://doi.org/10.1007/978-3-642-79547-3_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79549-7

  • Online ISBN: 978-3-642-79547-3

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