Abstract
The use of liposomes as model membranes has made significant contributions to our understanding and current knowledge of lipid bilayers and their interaction with various proteins (McConnell, 1983; Papahadjopoulos, et al., 1990). However, the potential use of liposomes as carriers of drugs and macromolecules, has taken much longer than expected to reach a successful conclusion in terms of clinical applications. One of the key problems in using liposomes as carriers is the lack of understanding about the parameters that control the interaction of liposomes with cells.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allen, TM, & Chonn, A (1987) . Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett., 223, 42–46.
Carpenter, G., & Cohen, S. (1976) 125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts. J. Cell Biol, 7.1, 59–171.
Chin, D, Straubinger, RM, Acton, S, Nathke, I, & Brodsky, FM (1989). 100-kD polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis. Proc. Natl. Acad. Sci. U.S.A., 86, 9289–9293.
Ciechnover, A., Schwartz, A.L., Dautry-Varsat, A., & Lodish, H.F. (1983) Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J. Biol. Chem. 258, 9681–9689.
Daleke, DL, Hong, K, & Papahadjopoulos, D (1990) . Endocytosis of liposomes by macrophages: binding, acidification and leakage of liposomes monitored by a new fluorescence assay. Biochim. Biophys. Acta, 1024, 352–366.
Dijkstra, J, van Galen, M, & Scherphof, G (1985) . Influence of liposome charge on the association of liposomes with Kupffer cells in vitro. Effects of divalent cations and competition with latex particles. Biochim. Biophys. Acta, 813, 287–297.
Düzgünes, N, Pedroso de Lima, MC, Stamatatos, L, Flasher, D, Alford, D, Friend”, DS, & Nir, S (1992) . Fusion activity and inactivation of influenza virus : kinetics of low pH-induced fusion with cultured cells. J. Gen. Virology, 73, 27–37.
Ellens, H, Bentz, J, Mason, D, Zhang, F, & White, J (1990). Fusion of influenza hemagglutinin-expressing fibroblasts ith glycophorin-bearing liposomes: role of hemagglutinin suface density. Biochemistry, 29, 9697–97 07.
Fadok, VA, Savill, JS, Haslett, C, Bratton, DL, Doherty, DE, Campbell, PA, & Henson, PM (1992) Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognized and remove apoptotic cells. J. Immunnology, 149, 4029–4035.
Fadok, VA, Voelker, DR, Campbell, PA, Cohen, JJ, Bratton, DL, & Henson, PM (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J. Immunology, 148, 2207–2216.
Felgner, PL, Thompson, TE, Barenholz, Y, & Lichtenberg, D (1983). Kinetics of transfer of gangliosides from their micelles to dipalmitoylphosphatidylcholine vesicles. Biochemistry, 22, 1670–1674.
Fidler, IJ, Raz, A, Fogler, WE, R. Kirsh, Bugelski, P, & Poste, G (1980). Design of liposomes to improve delivery of macrophage-augmenting agents to alveolar macrophages. Cancer Res., 40, 4460–4466.
Fraley, RT, Straubinger, RM, Rule, G, Springer, EL, & Papahadjopoulos, D (1981). Liposome-mediated delivery of deoxyribonucleic acid to cells: Enhanced efficiency of delivery related to lipid composition and incubation conditions. Biochemistry, 20, 6978–6987.
Gabizon, A, & Papahadjopoulos, D (1988). Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc. Natl. Acad. Sci. USA, 85, 6949-6953.
Goldstein, JL, & Brown, MS (1977). The low-density lipoprotein pathway and its elation to atherosclerosis. Annu. Rev. Biochem., 46, 897-930.
Gregoriadis, G, & Ryman, B (1972). Fate of protein-containing liposomes injected into rats. An approach to the treatment of storage diseases. Eur. J. Biochem., 24, 485–491.
Heath, TD, Lopez, NG, & Papahadjopoulos, D (1985). The effects of liposome size and surface charge on liposome-mediated delivery of methotrexate-g-aspartate to cells in vitro. Biochim. Biophys. Acta, 820, 74–84.
Helenius, A, Mellman, I, Wall, D, & Hubbard, A (1983). Endosomes. Trends Bioche. Sci, 8, 245–250.
Hsu, MJ, & Juliano, RL (1982). Interaction of liposomes with the reticuloendothelial system. II : Nonspecific and receptor-mediated uptake of liposomes by mouse peritoneal macrophages. Biochimica et Biophysica Acta, 720, 411–419.
Lee, K-D, Hong, K, & Papahadjopoulos, D (1992). Recognition of liposome by cells : in vitro binding and endocytosis mediated by specific lipid headgroups and surface charge density. Biochim. Biophys. Acta, 1103, 185–197.
Lee, K-D, Nir, S, & Papahadjopoulos, D (1993). Quantitative analysis of liposome-cell interactions in vitro: rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes. Biochemistry, 32, 889–899.
Lee, K-D, Pitas, RE, & Papahadjopoulos, D (1992). Evidence that the scavenger receptor is not involved in the uptake of negatively charged liposomes in cells. Biochim. Biophys. Acta, 1111, 1–6.
McConnell, HM (1983). . New York: Academic Press.
Nir, S, Düzgünes, N, Pedroso de Lima, MC, & Hoekstra, D (1990) Fusion of enveloped viruses ity cells and liposomes. Cell Biophys., 17, 181–201.
Nir, S, Klappe, K, & Hoekstra, D (1986). Kinetics and extent of fusion between Sendai virus and erythrocyte ghosts: application of a mass action kinetic model. Biochemistry, 25, 2155–2161.
Nishikawa, K, Arai, H, & Inoue, K (1990). Scavenger receptor-mediated uptake and metabolism of lipid vesicles containing acidic phospholipids by mouse peritoneal macrophages. J. Biol. Chem., 265(9), 5226–5231.
Pagano, RE, & Takeichi, M (1977). Adhesion of phospholipid vesicles to Chinese hamster fibroblasts. Role of cell suface proteins. J. Cell Biol., 74, 531–546.
Papahadjopoulos, D, Nir, S, & Düzgünes, N (1990). Molecular mechanisms of calcium-induced membrane fusion, J. Bioenergetics and Membranes, 22, 157–179.
Pastan, I, & Willingham, MC (1983). Receptor-mediated endocytosis: coated pits, receptosomes and the Golgi. Trends Biochem. Sci., 8, 250–254.
Pastan, IH, & Willingham, MC (1981). Journey to the center of the cell: role of the receptosome. Science, 214, 504–509.
Pedroso de Lima, MC, Nir, S, Flasher, D, Klappe, K, Hoekstra, D, & Düzgünes, N (1991). Biochim. Biophys. Acta, 1070, 446–454.
Pitas, RE, Innerarity, TL, Arnold, KS, & Mahley, RW (1979). Rate and equilibrium constants for binding of apo-E HDLc (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: evidence for multiple receptor binding of apo-E HDLc. Proc. Natl. Acad. Sci. U.S.A., 76, 2311-2315.
Poste, G, Bucana, C, Raz, A, Bugelski, P, Kirsh, R, & Fidler, IJ (1982). Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res., 42, 1412–1422.
Raz, A, Bucana, C, Fogler, WE, Poste, G, & Fidler, IJ (1981). Biochemical, morphological, and ultrastructural studies on the uptake of liposomes by murine macrophages. Cancer Research, 41, 487–494.
Schroit, AJ, & Fidler, IJ (1982). Effects of liposome structure and lipid composition on the activation of the tumoricidal properties of macrophages by liposomes containing muramyl dipeptide. Cancer Research, 42, 161–167.
Senior, J, Crawley, JCW, & Gregoriadis, G (1985). Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection. Biochim. Biophys. Acta, 839, 1–8.
Stahl, P, & Schwarts, AL (1986). Receptor-mediated endocytosis. J. Clin. Invest., 77, 657–662.
Straubinger, RM, Hong, K, Friend, DS, & Papahadjopoulos, D (1983). Endocytosis of liposomes and intracellular fate of encapsulated contents : encounter with a low-pH compartment after internalization in coated vesicles. Cell, 32, 1069–1079.
Straubinger, RM, Papahadjopoulos, D, & Hong, K (1990). Endocytosis and intracellular fate of liposomes using pyranine as a probe. Biochemistry, 29, 4929–4939.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Lee, KD., Papahadjopoulos, D. (1995). Interaction of liposomes with cells in vitro . In: De Lima, M.C.P., Düzgüneş, N., Hoekstra, D. (eds) Trafficking of Intracellular Membranes:. NATO ASI Series, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79547-3_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-79547-3_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79549-7
Online ISBN: 978-3-642-79547-3
eBook Packages: Springer Book Archive