Abstract
The endoplasmic reticulum (ER) maintains a highly specialized environment that supports rapid and efficient protein folding and assembly. Viral membrane proteins have been used as tools to understand these processes. In this paper, we will review commonly used techniques that may be employed to monitor protein folding and assembly. Such approaches can be used to characterize folding factors in the ER as well as to develop a more complete understanding of viral membrane protein biosynthesis. Such information is required to fully evaluate the effects of mutations on viral membrane protein structure and function.
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Doms, R.W., Abedon, S.T., Richardson, T.M. (1995). Viral Membrane Proteins as Tools to Study Protein Folding, Assembly, and Transport. In: De Lima, M.C.P., Düzgüneş, N., Hoekstra, D. (eds) Trafficking of Intracellular Membranes:. NATO ASI Series, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79547-3_10
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DOI: https://doi.org/10.1007/978-3-642-79547-3_10
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