Diversity and Regulation of Cytochromes P450 in Aquatic Species

  • John J. Stegeman
Part of the NATO ASI Series book series (volume 90)

Abstract

Knowledge of the multiplicity, function and regulation of cytochrome P450 forms in non-mammalian and non-traditional species continues to grow in importance. Microsomal cytochromes P450 that are involved in xenobiotic metabolism can play critical roles in determining the susceptibility or resistance of organisms to the toxic action of numerous anthropogenic chemicals and natural products. Currently, these processes are understood far better in rodent models than in wild or cultivated species that provide food and material resources, or in species that are important to the functioning of ecosystems that sustain those resource populations. Knowledge of P450 systems in these various groups is important for chemical therapeutics of species in culture, and to management decisions related to the assessment of chemical effects, and the protection of wild species. Non-traditional species are also important as potential models for novel features of P450 systems, and to discerning the molecular basis underlying species differences and similarities in responses to xenobiotics. In this paper we summarize aspects of P450 systems in selected groups of aquatic species, focusing first on recent findings regarding the diversity of P450 forms. Secondly, we summarize aspects of the use of induction of cytochrome P4501A forms as a biomarker of exposure to Ah-receptor agonists.

Keywords

Hydrocarbon Cortisol PAHs Testosterone Estradiol 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • John J. Stegeman
    • 1
  1. 1.Biology DepartmentWoods Hole Oceanographic InstitutionWoods HoleUSA

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