Skip to main content
SpringerLink
Log in

Diversity and Regulation of Cytochromes P450 in Aquatic Species

  • Conference paper
Molecular Aspects of Oxidative Drug Metabolizing Enzymes

Part of the book series: NATO ASI Series ((ASIH,volume 90))

Abstract

Knowledge of the multiplicity, function and regulation of cytochrome P450 forms in non-mammalian and non-traditional species continues to grow in importance. Microsomal cytochromes P450 that are involved in xenobiotic metabolism can play critical roles in determining the susceptibility or resistance of organisms to the toxic action of numerous anthropogenic chemicals and natural products. Currently, these processes are understood far better in rodent models than in wild or cultivated species that provide food and material resources, or in species that are important to the functioning of ecosystems that sustain those resource populations. Knowledge of P450 systems in these various groups is important for chemical therapeutics of species in culture, and to management decisions related to the assessment of chemical effects, and the protection of wild species. Non-traditional species are also important as potential models for novel features of P450 systems, and to discerning the molecular basis underlying species differences and similarities in responses to xenobiotics. In this paper we summarize aspects of P450 systems in selected groups of aquatic species, focusing first on recent findings regarding the diversity of P450 forms. Secondly, we summarize aspects of the use of induction of cytochrome P4501A forms as a biomarker of exposure to Ah-receptor agonists.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Addison R and Brodie P (1984) Characterization of ethoxyresorufin O-deethylase in grey seal Halichoerus grypus. Comp Biochem Physiol 79C: 261–263.

    CAS  Google Scholar 

  • Addison R, Brodie P, Edwards A and Sadler M (1986) Mixed function oxidase activity in the harbour seal (Phoca vitulina) from Sable Is., N.S. Comp Biochem Physiol 85C: 121–124. Bellward GD, Norstrom RJ, Whitehead PE, Elliot JE, Bandiera SM, Dworschak C, Chang T, Forbes S, Cadario B, Hart LE and Cheng KM (1990) Comparison of polychlorinated dibenzodioxin levels with hepatic mixed-function oxidase induction in great blue herons. J Toxicol Environ Health 30: 33–52.

    Google Scholar 

  • Bend JR and James MO (1978) Xenobiotic metabolism in marine and freshwater species. In Biochemical and Biophysical Perspectives in Marine Biology. DC Malins and JR Sargent Academic Press New York. 125–188.

    Google Scholar 

  • Bend JR, Pohl RJ, Arinc E and Philpot RM (1977) Hepatic microsomal and solubilized mixed-function oxidase systems from the little skate, Raja erinacea, a marine elasmobranch. In Microsomes and Drug Oxidations. V Ullrich, I Roots, A Hildebrandt, RW Estabrook and AH Conney Pergamon Oxford. 160–169.

    Google Scholar 

  • Binder RL and Stegeman JJ (1983) Basal levels and induction of hepatic aryl hydrocarbon hydroxylase activity during the embryonic period of development in brook trout. Biochem Pharmacol 32: 1324–1327.

    Article  PubMed  CAS  Google Scholar 

  • Buhler D (1992) Personal communication.

    Google Scholar 

  • Burbach KM, Poland A and Bradfield CA (1992) Cloning of the Ah receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Nat Acad Sci USA 89: 8185–8189.

    Article  PubMed  CAS  Google Scholar 

  • Celander M and Forlin L (1991) Catalytic activity and immunochemical quantification of hepatic cytochrome P-450 in beta-naphthoflavone and isosafrole treated rainbow trout (Oncorhyttchus mykiss). Fish Physiol Biochem 9: 189–197.

    Article  CAS  Google Scholar 

  • Celander M, Ronis M and Forlin L (1989) Initial characterization of a constitutive cytochrome P-450 isoenzyme in rainbow trout liver. Mar Environ Res 28: 9–13.

    Article  CAS  Google Scholar 

  • Devaux A, Pesonen M, Monod G and Andersson T (1992) Glucocorticoid-mediated potentiation of P450 induction in primary culture of rainbow trout hepatocytes. Biochem Pharmacol 43: 898–901.

    Article  PubMed  CAS  Google Scholar 

  • Ellenton J, Brownlee L and Hollebone B (1985) Aryl hydrocarbon hydroxylase levels in herring gull embryos from different locations on the Great Lakes. Environ Toxicol Chem 4: 615–622.

    Article  CAS  Google Scholar 

  • Elskus AA, Pruell R and Stegeman JJ (1992) Endogenously-mediated, pretranslational suppression of cytochrome P4501A in PCB-contaminated flounder. Mar Environ Res 34: 97–101.

    Article  CAS  Google Scholar 

  • Elskus AA and Stegeman JJ (1989) Induced cytochrome P-450 in Fundulus heteroclitus associated with environmental contamination by polychlorinated biphenyls and polynuclear aromatic hydrocarbons. Mar Environ Res 27: 31–50.

    Article  CAS  Google Scholar 

  • Elskus AA, Stegeman JJ, Susani LC, Black D, Pruell RJ and Fluck SJ (1989) Polychlorinated biphenyls concentration and cytochrome P-450E expression in winter flounder from contaminated environments. Mar Environ Res 28: 25–30.

    Article  CAS  Google Scholar 

  • Ema M, Sogawa K, Watanabe N, Chujoh Y, Matsushita N, Gotoh O, Funae Y and Fuji-Kuriyama Y (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Comm 184: 246–253.

    Google Scholar 

  • Engelhardt F (1982) Hydrocarbon metabolism and Cortisol balance in oil-exposed ringed seals, Phoca hispida. Comp Biochem Physiol 72C: 133–136.

    CAS  Google Scholar 

  • Foureman G, White N and Bend J (1983) Biochemical evidence that winter flounder (Pseudopleuronectes americanus) have induced hepatic cytochrome P-450-dependent monooxygenase activities. Can J Fish Aquat Sci 40: 854–865.

    Article  CAS  Google Scholar 

  • George S (1992) personal communication.

    Google Scholar 

  • Goksoyr A (1985) Purification of hepatic microsomal cytochromes P-450 from fi-naphthoflavone-treated Atlantic cod (Gadus morhua), a marine teleost fish. Biochim Biophys Acta 840: 409–417.

    Article  PubMed  CAS  Google Scholar 

  • Gokseyr A, Andersson T, Forlin L, Stenersen J, Snowberger EA, Woodin BR and Stegeman JJ (1988) Xenobiotic and steroid metabolism in adult and foetal piked (minke) whales, Balaenoptera acutorostrata. Mar Environ Res 24: 9–13.

    Article  Google Scholar 

  • Gokseyr A, Andersson T, Hansson T, Klungsoyr J, Zhang Y and Forlin L (1987) Species characteristics of the hepatic xenobiotic and steroid biotransformation systems of two teleost fish, Atlantic cod (Gadus morhua) and rainbow trout ( Salmo gairdneri ). Toxicol Appl Pharmacol 89: 347–360.

    Article  Google Scholar 

  • Gokseyr A, Beyer J, Larsen HE, Andersson T and Forlin L (1992) Cytochrome P450 in seals: monooxygenase activities, immunochemical cross-reactions and response to phenobarbital treatment. Mar Environ Res 34: 113–116.

    Article  Google Scholar 

  • Goksoyr A, Solbakken J, Tarlebo J and Klungsoyr J (1986) Initial characterization of the hepatic microsomal cytochrome P-450-system of the piked whale (minke) Balaenoptera acutorostrata. Mar Environ Res 19: 185–203.

    Article  Google Scholar 

  • Gooch JW, Elskus AA, Kloepper-Sams PJ, Hahn ME and Stegeman JJ (1989) Effects of ortho and non-ortho substituted polychlorinated biphenyl congeners on the hepatic monooxygenase system in scup ( Stenotomus chrysops ). Toxicol Appl Pharmacol 98: 422–433.

    Article  PubMed  CAS  Google Scholar 

  • Haasch ML, Quardokus EM, Sutherland LA, Goodrich MS and Lech JJ (1993) Hepatic CYP1A1 induction in rainbow trout by continuous flowthrough exposure to fi-naphthoflavone. Fundam Appl Toxicol 20: 72–82.

    Article  PubMed  CAS  Google Scholar 

  • Haasch ML, Wejksnora PJ and Lech JJ (1990) Molecular aspects of cytochrome P450 induction in rainbow trout. Toxicologist 10: 322

    Google Scholar 

  • Haasch ML, Wejksnora PJ, Stegeman JJ and Lech JJ (1989) Cloned rainbow trout liver PI450 complementary DNA as a potential environmental monitor. Toxicol Appl Pharmacol 98: 362–368.

    Article  PubMed  CAS  Google Scholar 

  • Hahn ME, Poland A, Glover E and Stegeman JJ (1992) The Ah receptor in marine animals: Phylogenetic distribution and relationship to P4501A inducibility. Mar Environ Res 34: 87–92.

    Article  CAS  Google Scholar 

  • Hahn ME, Poland A, Glover E and Stegeman JJ (1993) Photoaffinity labeling of the Ah receptor: Phylogenetic survey of diverse vertebrate and invertebrate species. Arch Biochem Biophys (submitted).

    Google Scholar 

  • Hahn ME and Stegeman JJ (1990) The role of biotransformation in the toxicity of marine pollutants. In Pour L’Avenir du Beluga Proc of the International Forum for the Future of the Beluga, Tadoussac, Quebec, Canada, 29 September–1 October, 1988 ).

    Google Scholar 

  • J Prescott and M Gauquelin Presses de l’Universite du Quebec Sillery, Quebec. 185–198.

    Google Scholar 

  • Hahn ME, Steiger GH, Calambokidas J, Shaw SD and Stegeman JJ (1991) Immunochemical characterization of cytochrome P450 in harbor seals (Phoca vitulina). 9th Biennial Conf on Biology of Marine Mammals p 30.

    Google Scholar 

  • Hansson T, Forlin L, Rafter J and Gustafsson J-A (1982) Regulation of hepatic steroid and xenobiotic metabolism in fish. In Cytochrome P-450, Biochemistry, Biophysics and Environmental Implications. E Hietanen, M Laitinen and O Hanninen Elsevier Biomedical Amsterdam. 217–224.

    Google Scholar 

  • Heilmann LJ, Sheen Y-Y, Bigelow SW and Nebert DW (1988) Trout P450IA1: cDNA and deduced protein sequence, expression in liver, and evolutionary significance. DNA 7: 379–387.

    Article  PubMed  CAS  Google Scholar 

  • Hoffman DJ, Rattner BA, Sileo L, Doucherty D and Kubiak TJ (1987) Embryotoxicity, teratogenicity, and aryl hydrocarbon hydroxylase activity in Forster’s terns on Green Bay, Lake Michigan. Environ Res 42: 176–184.

    Article  PubMed  CAS  Google Scholar 

  • James MO (1989) Cytochrome P450 monooxygenases in crustaceans. Xenobiotica 19: 1063–1076.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan LAE, Schultz ME, Schultz RJ and Crivello JF (1991) Nitrosodiethylamine metabolism in the viviparous fish Poeciliopsis: Evidence for the existence of liver P450pj activity and expression. Carcinogenesis 12: 647–652.

    Article  PubMed  CAS  Google Scholar 

  • Kleinow KM, Haasch ML, Williams DE and Lech JJ (1990) A comparison of hepatic P450 induction in rat and trout ( Oncorhynchus mykiss ): Delineation of the site of resistance of fish to phenobarbital-type inducers. Comp Biochem Physiol C 96C: 259–270.

    Article  PubMed  CAS  Google Scholar 

  • Kloepper-Sams PJ and Stegeman JJ (1992) The effect of temperature acclimation on the expression of cytochrome P4501A mRNA and protein in the fish Fundulus heteroclitus. Arch Biochem Biophys 299: 38–46.

    Article  PubMed  CAS  Google Scholar 

  • Klotz AV, Stegeman JJ and Walsh C (1983) An aryl hydrocarbon hydroxylating hepatic cytochrome P-450 from the marine fish Stenotomus chrysops. Arch Biochem Biophys 226: 578–592.

    Article  PubMed  CAS  Google Scholar 

  • Klotz AV, Stegeman JJ, Woodin BR, Snowberger EA, Thomas PE and Walsh C (1986) Cytochrome P-450 isozymes from the marine teleost Stenotomus chrysops: their roles in steroid hydroxylation and the influence of cytochrome Arch Biochem Biophys 249: 326–338.

    CAS  Google Scholar 

  • Kreamer GL, Squibb K, Gioeli D, Garte SJ and Wirgin I (1991) Cytochrome P450IA mRNA expression in feral Hudson River tomcod. Environ Res 55: 64–78.

    Article  PubMed  CAS  Google Scholar 

  • Leaver MJ, Burke MD, George SG, Davies JM and Raffaelli D (1988) Induction of cytochrome P450 monooxygenase activities in plaice by ’model’ inducers and drilling muds. 24: 27–30.

    CAS  Google Scholar 

  • Lech JJ, Vodicnik MJ and Elcombe CR (1982) Induction of monooxygenase activity in fish. In Aquatic Toxicology. Raven Press 107–148.

    Google Scholar 

  • Lindstrom-Seppa P, Huuskonen S, Pesonen M, Muona P and Hanninen O (1992) Unbleached pulp mill effluents affect cytochrome P450 monooxygenase enzyme activities. Mar Environ Res 34: 157–161.

    Article  CAS  Google Scholar 

  • Livingstone DR, Kirchin MA and Wiseman A (1989) Cytochrome P450 and oxidative metabolism in molluscs. 19: 1041–1062.

    CAS  Google Scholar 

  • Lorenzana RM, Hedstrom OR and Buhler DR (1988) Localization of cytochrome P-450 in the head and trunk kidney of rainbow trout ( Salmo gairdneri ). Toxicol Appl Pharmacol 96: 159–167.

    Article  PubMed  CAS  Google Scholar 

  • Luxon PL, Hodson PV and Borgmann U (1987) Hepatic aryl hydrocarbon hydroxylase activity of lake trout ( Salvelinus namaycush) as an indicator of organic pollution. Environ Toxicol Chem 6: 649–657.

    CAS  Google Scholar 

  • Malins DC, Krahn MM, Brown DW, Rhodes LD, Myers MS, McCain BB and Chan S-L (1985) Toxic chemicals in marine sediment and biota from Mukilteo, WA: Relationships with hepatic neoplasms and other hepatic lesions in English sole ( Parophrys vetulus ). J Natl Cancer Inst 74: 487–494.

    PubMed  CAS  Google Scholar 

  • Malins DC, McCain BB, Brown DW, Chan SL, Myers MS, Landahl JT, Prohaska PG, Friedman AJ, Rhodes LD, Burrows DG, Gronlund WD and Hodgins HO (1984) Chemical pollutants in sediments and diseases of bottom-dwelling fish in Puget Sound, WA. Environ Sci Technol 18: 705–713.

    Article  CAS  Google Scholar 

  • Miller MR, Hinton DE and Stegeman JJ (1989) Cytochrome P-450E induction and localization in gill pillar (endothelial) cells of scup and rainbow trout. Aquat Toxicol 14: 307–322.

    Article  CAS  Google Scholar 

  • Miranda CL, Wang J-L, Henderson MC, Zhao X, Guengerich FP and Buhler DR (1991) Comparison of rainbow trout and mammalian cytochrome P450 enzymes: Evidence for structural similarity between trout P450 LMC5 and human P450IIIA4. Biochem Biophys Res Commun 176: 558–563.

    Article  PubMed  CAS  Google Scholar 

  • Monosson E and Stegeman JJ (1991) Cytochrome P450E (P450IA) induction and inhibition in winter flounder by 3,3’,4,4’-tetrachlorobiphenyl: Comparison of response in fish from Georges Bank and Narragansett Bay. Environ Toxicol Chem 10: 765–774.

    Article  CAS  Google Scholar 

  • Munkittrick KR, Kraak GJVD, McMaster ME and Portt CB (1992) Response of hepatic MFO activity and plasma sex steroids to secondary treatment of bleached kraft pulp mill effluent and mill shutdown. Environ Tox Chem 11: 1427–1439.

    Article  CAS  Google Scholar 

  • Nelson D and Strobel H (1987) Evolution of cytochrome P450 proteins. Mol Biol Evol 4: 572–593.

    PubMed  CAS  Google Scholar 

  • Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O, Okuda K and Nebert DW (1993) The P450 Superfamily — Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature. DNA Cell Biol 12: 1–51.

    Article  PubMed  CAS  Google Scholar 

  • Pajor AM, Stegeman JJ, Thomas P and Woodin BR (1990) Feminization of the hepatic microsomal cytochrome P-450 system in brook trout by estradiol, testosterone, and pituitary factors. J Exper Zool 253: 51–60.

    Article  CAS  Google Scholar 

  • Payne J, Fancey L, Rahimtula A and Porter E (1987) Review and perspective on the use of mixed-function oxygenase enzymes in biological monitoring. Comp Biochem Physiol 86C: 233–245.

    CAS  Google Scholar 

  • Payne JF (1976) Field evaluation of benzopyrene hydroxylase induction as a monitor for marine pollution. Science 191: 945–946.

    Article  PubMed  CAS  Google Scholar 

  • Poland A and Knutson JC (1982) 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Ann Rev Pharmacol Toxicol 22:517–554.

    Google Scholar 

  • Sakai N, Tanaka M, Adachi S, Miller WL and Nagahama Y (1992) Rainbow trout cytochrome-P-450cl7 (17-alpha-Hydroxylase/ 17,20-Lyase) - cDNA cloning, enzymatic properties and temporal pattern of ovarian P-450cl7 messenger RNA expression during oogenesis. FEBS Lett 301: 60–64.

    Article  PubMed  CAS  Google Scholar 

  • Smolowitz RM, Hahn ME and Stegeman JJ (1991) Immunohistochemical localization of cytochrome P450IA1 induced by 3,3’,4,4-tetrachlorobiphenyl and by 2,3,7,8-tetrachlorodibenzofuran in liver and extrahepatic tissues of the teleost Stenotomus chrysops (scup). Drug Metab Dispos 19: 113–123.

    PubMed  CAS  Google Scholar 

  • Spies R, Felton J and Dillard L (1982) Hepatic mixed function oxidases in California flatfishes are increased in contaminated environments and by oil and PCB ingestion. Marine Biol 70: 117–127.

    Article  CAS  Google Scholar 

  • Spies RB, D.W. Rice J and Felton J (1988) Effects of organic contaminants on reproduction of the starry flounder Platichthys stellatus in San Francisco Bay. I. Hepatic contamination and mixed-function oxidase ( MFO) activity during the reproductive season. Mar Biol 98: 181–189.

    Article  CAS  Google Scholar 

  • Stegeman JJ (1979) Temperature influence on basal activity and induction of mixed function oxygenase activity in Fundulus heteroclitus. J Fish Res Board Can 36: 1400–1405.

    Article  CAS  Google Scholar 

  • Stegeman JJ (1981) Polynuclear aromatic hydrocarbons and their metabolism in the marine environment. In Polycyclic Hydrocarbons and Cancer. HV Gelboin and POP Ts’o Academic Press New York. 1–60.

    Google Scholar 

  • Stegeman JJ (1989) Cytochrome P450 forms in fish: catalytic, immunological and sequence similarities. Xenobiotica 19: 1093–1110.

    Article  PubMed  CAS  Google Scholar 

  • Stegeman JJ (1993) unpublished results.

    Google Scholar 

  • Stegeman JJ and Binder RL (1979) High benzo[a]pyrene hydroxylase activity in the marine fish Stenotomus versicolor. Biochem Pharmacol 28: 1686–1688.

    Article  PubMed  CAS  Google Scholar 

  • Stegeman JJ, Brouwer M, DiGiulio RT, Forlin L, Fowler BM, Sanders BM and Van Veld P (1992) Molecular responses to environmental contamination: Enzyme and protein systems as indicators of contaminant exposure and effect. In Biomarkers. Biochemical, Physiological, and Histological Markers of Anthropogenic Stress. RJ Huggett, RA Kimerle, PM Mehrle and HL Bergman Lewis Boca Raton. 235–335.

    Google Scholar 

  • Stegeman JJ and Hahn ME (1993) Biochemistry and molecular biology of monooxygenases: Current perspectives on the forms, function and regulation of cytochromes P450. In Aquatic Toxicology: Cellular, Molecular and Biochemical Perspectives. D Malins and G Ostrander Lewis Boca Raton Fla. 87–206.

    Google Scholar 

  • Stegeman JJ, Kloepper-Sams PJ and Farrington JW (1986) Monooxygenase induction and chlorobiphenyls in the deep-sea fish Coryphaenoides armatus. Science 231: 1287–1289.

    Article  PubMed  CAS  Google Scholar 

  • Stegeman JJ, Miller M, Singh H and Hinton D (1987) Cytochrome P450E induction and localization in liver and endothelial tissue of extrahepatic organs of scup. Fed Proc 46: 379.

    Google Scholar 

  • Stegeman JJ, Miller MR and Hinton DE (1989) Cytochrome P450IA1 induction and localization in endothelium of vertebrate (teleost) heart. Mol Pharmacol 36: 723–729.

    PubMed  CAS  Google Scholar 

  • Stegeman JJ, Renton KW, Woodin BR, Zhang Y-S and Addison RF (1990) Experimental and environmental induction of cytochrome P450E in fish from Bermuda waters. J Exp Mar Biol Ecol 138: 49–67.

    Article  CAS  Google Scholar 

  • Stegeman JJ, Smolowitz RM and Hahn ME (1991) Immunohistochemical localization of environmentally induced cytochrome P450IA1 in multiple organs of the marine teleost Stenotomus chrysops (scup). Toxicol Appl Pharmacol 110: 486–504.

    Article  PubMed  CAS  Google Scholar 

  • Stegeman JJ, Teng FY and Snowberger EA (1987) Induced cytochrome P-450 in winter flounder ( Pseudopleuronectes americanus) from coastal Massachusetts evaluated by catalytic assay and monoclonal antibody probes. Can J Fish Aquat Sei 44: 1270–1277.

    Google Scholar 

  • Stegeman JJ, Woodin BR and Goksoyr A (1988) Apparent cytochrome P-450 induction as an indication of exposure to environmental chemicals in the flounder Platichthys flesus. Mar Ecol Prog Ser 46: 55–60.

    Article  CAS  Google Scholar 

  • Stegeman JJ, Woodin BR and Smolowitz RM (1990) Structure, function and regulation of cytochrome P-450 forms in fish. Biochem Soc Trans 18: 19–21.

    CAS  Google Scholar 

  • Tanaka M and Sakai NN Y. (1991). cDNA encoding P450 aromatase and P450cl7 lyase of medaka and rainbow trout; their expression and cloning in the ovary. 2nd International Marine Biotech Conf (IMBC) Baltimore 1991

    Google Scholar 

  • Van Veld PA, Patton JS and Lee RF (1988) Effect of preexposure to dietary benzo[a]pyrene (BP) on the first-pass metabolism of BP by the intestine of toadfish (Opsamus tau): in vivo studies using portal vein-catheterized fish. Toxicol Appl Pharmacol 92: 255–265.

    Article  PubMed  Google Scholar 

  • Van Veld PA, Westbrook DJ, Woodin BR, Hale RC, Smith CL, Huggett RJ and Stegeman JJ (1990) Induced cytochrome P-450 in intestine and liver of spot ( Leiostomus xanthurus) from a polycyclic aromatic hydrocarbon contaminated environment. Aquatic Toxicol 17: 119–132.

    Article  Google Scholar 

  • Varanasi U, Collier TK, Williams DE and Buhler DR (1986) Hepatic cytochrome P-450 isozymes and aryl hydrocarbon hydroxylase in English sole ( Parophyrs vetulus ). Biochem Pharmacol 35: 2967–2971.

    Article  PubMed  CAS  Google Scholar 

  • Watanabe S, Shimada T, Nakamura S, Nishiyama N, Yamashita N, Tanabe S and Tatsukawa R (1989) Specific profile of liver microsomal cytochrome P-450 in dolphin and whales. Mar Environ Res 27: 51–65.

    Article  CAS  Google Scholar 

  • Waxman DJ, Pampori NA, Ram PA, Agrawal AK and Shapiro BH (1991) Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proc Natl Acad Sei USA 88: 6868–6872.

    Article  CAS  Google Scholar 

  • White RD, Hahn ME, Lockhart WL and Stegeman JJ (1993) The hepatic microsomal cytochrome P450 system in beluga whales (Delphinapterus leucas). Toxicol Appl Pharmacol (in press)

    Google Scholar 

  • Williams DE and Buhler DR (1982) Purification of cytochromes P-448 from ß- naphthoflavone-treated rainbow trout. Biochim Biophys Acta 717: 398–404.

    Article  PubMed  CAS  Google Scholar 

  • Williams DE and Buhler DR (1983) Comparative properties of purified cytochrome P-448 from b-naphthoflavone treated rats and rainbow trout. Comp Biochem Physiol 75C: 25–32.

    Article  CAS  Google Scholar 

  • Williams DE and Buhler DR (1984) Benzo[a]pyrene hydroxylase catalyzed by purified isozymes of cytochrome P-450 from ß-naphthoflavone-fed rainbow trout. Biochem Pharm 33: 3743–3753.

    Article  PubMed  CAS  Google Scholar 

  • Zhang YS, Goksoyr A, Andersson T and Forlin L (1991) Initial purification and characterization of hepatic microsomal cytochrome P-450 from BNF-treated perch ( Perca fluviatilis ). Comp Biochem Physiol B 98B: 97–103.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biology Department, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts, 02543, USA

    John J. Stegeman

Authors
  1. John J. Stegeman
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Biology, Middle East Technical University, Inönü Bulvari, Ankara, 06531, Turkey

    Emel Arinç

  2. Department of Toxicology, University of Connecticut Health Center, Farmington, Connecticut, 06032, USA

    John B. Schenkman

  3. Department of Toxicology, North Carolina State University, Raleigh, North Carolina, 27695, USA

    Ernest Hodgson

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Stegeman, J.J. (1995). Diversity and Regulation of Cytochromes P450 in Aquatic Species. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Oxidative Drug Metabolizing Enzymes. NATO ASI Series, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79528-2_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79528-2_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79530-5

  • Online ISBN: 978-3-642-79528-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation