Drug Metabolism, Lipid Peroxidation and Glutathione

  • Wolfgang Klinger
Part of the NATO ASI Series book series (volume 90)


Cytochrome P-450 (P450) mediated drug metabolism can be connected with the creation of free oxygen radicals such as superoxide radical anion (O 2 .− ) and hydroxyl radical (OH.), and hydrogen peroxide (H2O2), so-called reactive oxygen species (ROS), by different ways and mechanisms. This is the beginning of a multistep chain mechanism (initiation, propagation and termination) in the further production of radicals and of peroxidation of lipids, proteins and DNA, leading finally to cell damage and cell death. The tripeptide glutathione (GSH) serves both as coupler in drug phase II metabolism to form glutathione conjugates and later on evtl. mercapturic acid derivatives, but also as radical scavenger, thus protecting liver parenchymal and other cells throughout the whole organism from damage. Thus there are different connections between the microsomal electron transport chain with P450 (with its functions as monooxygenase, oxidase and peroxidase) and GSH.


Superoxide Radical Anion Export Rate Brain Microsome Oxygen Radical Scavenger GSSG Concentration 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Wolfgang Klinger
    • 1
  1. 1.Institute of Pharmacology and ToxicologyFriedrich-Schiller-University of JenaJenaGermany

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