The Role of Oxidative Enzymes in the Metabolism and Toxicity of Pesticides

  • Ernest Hodgson
  • Randy L. Rose
  • Nancy H. Adams
  • Nora J. Deamer
  • Mary Beth Genter
  • Krishnappa Venkatesh
  • Patricia E. Levi
Part of the NATO ASI Series book series (volume 90)

Abstract

Xenobiotics, including pesticides (Hodgson & Levi, 1992, Levi & Hodgson, 1991), are metabolized by many enzymes including: cytochrome P450s (P450); flavin-containing monooxygenases (FMO); prostaglandin synthetase; molybdenum hydroxylases; alcohol dehydrogenase; aldehyde dehydrogenase; esterases; and a variety of transferases, particularly the glutathione transferases. Of these P450 appears to be the most important, followed by the FMO. It should also be remembered that pesticides may serve not only as substrates for these enzymes but, particularly in the case of P450, may serve also as inhibitors and/or inducers. The toxicological implications of these multiple roles are important and are illustrated by our studies of methylenedioxyphenyl (MDP) compounds, of the herbicide synergist tridiphane and the herbicide, dichlobenil, of metabolism in target tissues and portals of entry, and of insect resistance to insecticides.

Keywords

Pyrene Parathion Diazinon Cypermethrin Disulfiram 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Ernest Hodgson
    • 1
  • Randy L. Rose
    • 1
  • Nancy H. Adams
    • 1
  • Nora J. Deamer
    • 1
  • Mary Beth Genter
    • 1
  • Krishnappa Venkatesh
    • 1
  • Patricia E. Levi
    • 1
  1. 1.Department of ToxicologyNorth Carolina State UniversityRaleighUSA

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