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Molecular Aspects of Oxidative Drug Metabolizing Enzymes pp 249–259Cite as

Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical

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Part of the book series: NATO ASI Series ((ASIH,volume 90))

Abstract

Dietary and nutritional factors are known to influence the biotransformation of drugs and environmental chemicals. Early studies by Wattenberg (Wattenberg, 1971) demonstrated that rats on commercial rat chow had a 68-fold higher intestinal benzo(a)pyrene hydroxylase activity than those on a purified diet. In human studies, ingestion of cabbage and brussels sprouts was shown to increase the metabolism of antipyrine and phenacetin (Conney, 1982, Pantuck and Pan tuck, 1978). Human volunteers on a low-protein diet had lower rates of metabolic clearance of antipyrine and theophylline than those on a high-protein diet (Kappas, et al., 1976). Recent studies demonstrated the transcriptional activation of specific cytochrome P450 genes by dietary chemicals (Pan, et al., 1993, Vang, et al., 1990) and the inhibition of nifedipine metabolism in humans after ingestion of grapefruit juice (Bailey, et al, 1990). Many of these studies have been discussed in several recent reviews (Anderson, et al., 1985, Bidlack, et al., 1986, Hathcock, 1985, Yang, et al., 1992, Yang and Yoo, 1988).

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Authors and Affiliations

  1. Laboratory for Cancer Research College of Pharmacy, Rutgers University, Piscataway, NJ, 08855, USA

    Chung S. Yang & Theresa J. Smith

Authors
  1. Chung S. Yang
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  2. Theresa J. Smith
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Editors and Affiliations

  1. Department of Biology, Middle East Technical University, Inönü Bulvari, Ankara, 06531, Turkey

    Emel Arinç

  2. Department of Toxicology, University of Connecticut Health Center, Farmington, Connecticut, 06032, USA

    John B. Schenkman

  3. Department of Toxicology, North Carolina State University, Raleigh, North Carolina, 27695, USA

    Ernest Hodgson

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© 1995 Springer-Verlag Berlin Heidelberg

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Yang, C.S., Smith, T.J. (1995). Modulation of Xenobiotic Metabolism and Toxicity by Dietary Chemical. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Oxidative Drug Metabolizing Enzymes. NATO ASI Series, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79528-2_14

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  • DOI: https://doi.org/10.1007/978-3-642-79528-2_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79530-5

  • Online ISBN: 978-3-642-79528-2

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