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Comparison between the Consanguinity Determination by a Multi-Locus Probe and Three Single-Locus Probes

  • L. E. Schwarz
  • E. Kattner
  • V. Mauer
  • V. Schneider
  • H. Pöche
Conference paper

Abstract

Two main types of genomic RFLP-analysis are used today. Single-Locus-Probes (SLP) and Multi-Locus-Probes (MLP). Both are equally informative, but the quantification of the MLP results is not generally accepted. The overall transmission probability of the bands calculated by the method of Evett and co-workers is slightly greater than expected by the Mendelian model, indicating that not every band represents only one allele. This leads to the fact that the Single-Locus-Probes are much more used than the MLP in uncomplicated paternity cases, even if one MLP is as informative as three or four SLPs combined.

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References

  1. Evett JW, Werrett DJ, Buckleton JS (1989) Paternity calculations from DNA multilocus profiles. J. Forensic Sci. Soc. 29: 249–254PubMedCrossRefGoogle Scholar
  2. Jeffreys A., Wilson V., Their SL (1985) Individual-specific “fingerprints” of human DNA. Nature 316: 76–79PubMedCrossRefGoogle Scholar
  3. Riche H, Schmidt V, Mauer V, Wandelt S, Schneider V (1993) Individualisierung und Identifizierung durch Schiffsschraubenkontakt zerstückelter Leichenteile mittels DNA-Technologie. Pathologe 14: 193–198Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • L. E. Schwarz
    • 1
  • E. Kattner
    • 2
  • V. Mauer
    • 1
  • V. Schneider
    • 1
  • H. Pöche
    • 1
  1. 1.Institut für Rechts-medizinF U BerlinDeutschland
  2. 2.Krankenhaus WandsbekDeutschland

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