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Absorption of Orally Administered Enzymes pp 39–46Cite as

Oral Route of Peptide and Protein Drug Delivery

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Abstract

Designing means to deliver peptide and protein drugs successfully to the systemic circulation by the oral route has been a challenge to scientists in drug delivery for many years [1]. The barriers to peptide and protein absorption from the gastrointestinal tract are well known. There are the enzymatic and penetration barriers [2–4]. Of the two, the enzymatic barrier historically has received more attention and appears to be the rate-limiting step in the intestinal penetration of small peptides such as leucine enkephalin and its analogs [5]. Numerous investigations have focused on the use of protease inhibitors, notably aprotinin [6–8], soy bean trypsin inhibitor [8–10], and amastatin [5] and on the use of formulations, notably microparticulates [11] to protect the encapsulated peptide and protein drugs from luminal proteases.

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Authors
  1. V. H. L. Lee
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© 1995 Springer-Verlag Berlin Heidelberg

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Lee, V.H.L. (1995). Oral Route of Peptide and Protein Drug Delivery. In: Absorption of Orally Administered Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79511-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-79511-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79513-8

  • Online ISBN: 978-3-642-79511-4

  • eBook Packages: Springer Book Archive

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