Oral Route of Peptide and Protein Drug Delivery
Designing means to deliver peptide and protein drugs successfully to the systemic circulation by the oral route has been a challenge to scientists in drug delivery for many years . The barriers to peptide and protein absorption from the gastrointestinal tract are well known. There are the enzymatic and penetration barriers [2–4]. Of the two, the enzymatic barrier historically has received more attention and appears to be the rate-limiting step in the intestinal penetration of small peptides such as leucine enkephalin and its analogs . Numerous investigations have focused on the use of protease inhibitors, notably aprotinin [6–8], soy bean trypsin inhibitor [8–10], and amastatin  and on the use of formulations, notably microparticulates  to protect the encapsulated peptide and protein drugs from luminal proteases.
KeywordsPermeability Cyclosporine Styrene Glucagon Renin
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