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Gene-targeting approaches in the study of cellular processes involved in growth or differentiation

Advances in the analysis of oncogenes, tumour-suppressor genes, cytokine/receptor systems and developmental control genes

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EJB Reviews 1994

Part of the book series: EJB Reviews 1994 ((EJB REVIEWS,volume 1994))

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Abstract

Recent advances in embryonic stem cell (ES) technology have made it possible to introduce mutations into the mouse genome by homologous recombination and thereby selectively generate mutant mice. Genetically manipulated mutant mice have contributed enormously to our understanding of the molecular functions of isolated genes and the mechanisms of cell growth and differentiation, as well as increasing our understanding of diseases such as cancer. Here, we will briefly summarise the recent advances in gene-targeting studies with particular emphasis on growth factors and their receptors, oncogenes, tumour-suppressor genes and developmental control genes.

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Abbreviations

ES cell:

embryonic stem cell

EC cell:

embryonic carcinoma cell

NGF:

nerve growth factor

BDNF:

brain-derived neurotrophin factor

NT:

neurotrophin

CNTF:

ciliary neurotrophic factor

LIF:

leukaemia inhibitory factor

IL:

interleukin

OSM:

oncostatin M

GM-CSF:

granulocyte macrophage-colony-stimulating factor

M-CSF:

macrophage-colony-stimulating factor

CNS:

central nervous system

Rb:

retinoblastoma

NF1:

neurofibromatosis 1

EGF-R:

epidermal growth factor receptor

TGF:

transforming growth factor.

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  1. Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg, D-37077, Göttingen, Germany

    Gen Yamada & Edward T. Stuart

  2. Department of Applied Chemistry and Chemical Engineering, Kagoshima University, Japan

    Kazuhisa Sugimura

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Yamada, G., Sugimura, K., Stuart, E.T. (1994). Gene-targeting approaches in the study of cellular processes involved in growth or differentiation. In: EJB Reviews 1994. EJB Reviews 1994, vol 1994. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79502-2_17

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