Signal-transduction therapy

A novel approach to disease management
  • Alexander Levitzki
Part of the EJB Reviews 1994 book series (EJB REVIEWS, volume 1994)


In the past decade it has become apparent that many diseases result from aberrations in signaling pathways. These include proliferative diseases such as cancers, atherosclerosis and psoriasis and inflammatory conditions such as sepsis, rheumatoid arthritis and tissue rejection. These findings refocused the research of the medical community to seek new modalities for disease management which essentially consist of designing drugs which intercept cell signaling. In this review, the emerging success in using tyrosine kinase blockers and other signal interceptors, such as protein kinase C blockers, Ras blockers, Ca2+ signaling inhibitors and estrogen antagonists which inhibit growth of cancer cells in vitro and in vivo, will be discussed. These signal interceptors, especially tyrosine-kinase blockers, are also able to block inflammatory responses and the proliferation of vascular smooth muscle cells and psoriatic keratinocytes. The utility of signal interceptors in analyzing signal-transduction pathways is also discussed.


Epidermal Growth Factor Receptor Autocrine Loop Dominant Negative Construct Psoriatic Keratinocytes Signal Interceptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



diacyl glycerol


carboxamide amino-imidazole


cellular tyrosine kinase (s)


epidermal growth factor


epidermal-growth-factor receptor


FK506-binding protein


inositol trisphosphate


kinase insert domain-containing receptor


microtubule-associated protein


microtubule-associated protein kinase


microtubule-associated protein kinase kinase


platelet-derived growth factor


platelet-derived growth factor receptor


protein kinase C


phospholipase C


protein-tyrosine kinase (s)


receptor tyrosine kinase(s)


transforming growth factor


vascular endothelial growth factor


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Copyright information

© FEBS 1994

Authors and Affiliations

  • Alexander Levitzki
    • 1
    • 2
  1. 1.Department of Biological Chemistry, Institute of Life SciencesThe Hebrew University of JerusalemJerusalemIsrael
  2. 2.SUGEN, Inc.Redwood CityUSA

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