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Hemoglobin function under extreme life conditions

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EJB Reviews 1994

Part of the book series: EJB Reviews 1994 ((EJB REVIEWS,volume 1994))

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Abstract

Considering the variety of species that depend on hemoglobin for oxygen transport, these molecules must execute their primary function under extreme environmental conditions. Hence, a thermodynamic analysis of oxygen binding with hemoglobins from different species reveals a series of adaptive mechanisms which are based on the thermodynamic connection between the binding of heterotropic effectors and the reaction with oxygen.

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Abbreviations

GriP 2 :

2, 3-bis-phosphoglycerate

InsP 6 :

inositol hexakisphosphate

InsP 5 :

inositol pentaphosphate

P 50 :

partial pressure of oxygen required to give 50% of the heme molecules saturated with oxygen

ΔH :

overall heat of oxygenation calculated from the van’t Hoff equation

HbA:

human adult hemoglobin

HbF:

human fetal hemoglobin.

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Authors and Affiliations

  1. Department of Experimental Medicine and Biochemical Sciences, University of Rome ‘Tor Vergata’, Italy

    Maria E. Clementi, Saverio G. Condò & Massimo Castagnola

  2. Institute of Chemistry and Clinical Chemistry, Faculty of Medicine and CNR Center ‘Chimica dei recettori e delle molecole biologicamente attive’, Catholic University, Rome, Italy

    Massimo Castagnola & Bruno Giardina

  3. Istituto di Chimica, Università Cattolica del “Sacro Cuore”, Largo F. Vito 1, I-00168, Roma, Italy

    Bruno Giardina

Authors
  1. Maria E. Clementi
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  2. Saverio G. Condò
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  3. Massimo Castagnola
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  4. Bruno Giardina
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© 1994 FEBS

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Clementi, M.E., Condò, S.G., Castagnola, M., Giardina, B. (1994). Hemoglobin function under extreme life conditions. In: EJB Reviews 1994. EJB Reviews 1994, vol 1994. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79502-2_11

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  • DOI: https://doi.org/10.1007/978-3-642-79502-2_11

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