The Complete Nucleotide Sequence of the DNA of Human Adenovirus Type 12

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 199/2)


In earlier work from this laboratory, we used human adenovirus type 12 (Ad12) extensively for basic research on the mechanism and the consequences of foreign DNA integration into mammalian genomes (Doerfler 1968, 1970; for recent reviews Doerfler 1991, 1992, 1993, 1995; Fechteler etal. 1995). The investigations on Ad12 DNA integration led to a long-standing interest in the biological significance of DNA methylation, its role in the long-term silencing of eukaryotic promoters, and the mechanism of de novo methylation of foreign DNA in mammalian cells (Sutter et al. 1978; Sutter and Doerfler 1980; Doerfler 1981, 1983, 1991, 1993, 1995). In the course of these studies it became necessary to perform nucleotide sequence determinations in various parts of the Ad12 genome. Recently, the entire nucleotide sequence was completed (Sprengel et al. 1994) and made generally available under EMBO Accession Number X73487. Complete nucleotide sequences were thus available for the DNAs of adenovirus type 2 (Ad2) (Roberts et al. 1986), Ad5 (Chroboczek et al. 1992), Ad12 (Sprengel et al. 1994), and Ad40 (Davison et al. 1993; Mautner et al. 1995).


Adenovirus Type Human Adenovirus Type Ad12 Genome 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Institut für GenetikUniversität zu KölnCologneGermany

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