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Post-transcriptional Control of Adenovirus Gene Expression

Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 199/2)

Abstract

Adenovirus genes are expressed in a defined, temporally controlled manner during the course of a lytic infection. The mechanisms responsible for this control have been the subject of intense study. These studies have shown that, although control of transcription initiation is a major determinant of the observed pattern of viral gene expression, post-transcriptional control is also crucial to a successful outcome of infection. It is these latter mechanisms which are the subject of this chapter.

Keywords

Splice Site Adenovirus Type mRNA Transport Polypyrimidine Tract Late Gene Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adam SA, Dreyfuss G (1987) Adenovirus proteins associated with mRNA and hnRNA in infected HeLa cells. J Virol 61: 3276–3283PubMedGoogle Scholar
  2. Adami G, Babiss LE (1991) DNA template effect on RNA splicing: two copies of the same gene in the same nucleus are processed differently. EMBO J 11: 3457–3465Google Scholar
  3. Akusjärvi G, Persson H (1981) Controls of RNA splicing and termination in the major late adenovirus transcription unit. Nature 292: 420–426PubMedGoogle Scholar
  4. Akusjärvi G, Pettersson U, Roberts RJ (1986) Structure and function of the adenovirus-2 genome. In: Doerfler W (ed) Adenovirus DNA: the viral genome and its expression. Martin Nijhoff, Boston, pp 53–95Google Scholar
  5. Aleström P, Akusjärvi G, Perricaudet M, Mathews MB, Klessig DF, Pettersson U (1980) The gene for polypeptide IX of adenovirus type 2 and its unspliced messenger RNA. Cell 19: 671–681PubMedGoogle Scholar
  6. Anderson CW, Schmitt RC, Smart JE, Lewis JB (1984) Early region 1B of adenovirus 2 encodes two coterminal proteins of 495 and 155 amino acid residues. J Virol 50: 387–396PubMedGoogle Scholar
  7. Babich A, Feldman LT, Nevins JR, Darnell JE, Weinberger C (1993) Effects of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol 3: 1212–1221Google Scholar
  8. Babiss LE, Ginsberg HS (1984) Adenovirus type 5 early region 1b gene product is required for efficient shutoff of host protein synthesis. J Virol 50: 202–212PubMedGoogle Scholar
  9. Babiss LE, Fisher PB, Ginsberg HS (1984) Effect on transformation of mutations in the early region 1b-encoded 21- and 55-kilodalton proteins of adenovirus 5. J Virol 52: 389–395PubMedGoogle Scholar
  10. Babiss LE, Ginsberg HS, Darnell JE Jr (1985) Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Mol Cell Biol 5: 2552–2558PubMedGoogle Scholar
  11. Bello LJ, Ginsberg HS (1967) Inhibition of host protein synthesis in type 5 adenovirus-infected cells. J Virol 1: 843–850PubMedGoogle Scholar
  12. Beltz GA, Flint SJ (1979) Inhibition of HeLa cell protein synthesis during adenovirus infection: restriction of cellular messenger RNA sequences to the nucleus. J Mol Biol 131: 353–373PubMedGoogle Scholar
  13. Berezney R, Coffey DS (1977) Nuclear matrix: isolation and characterization of a framework structure from rat liver nuclei. J Cell Biol 73: 616–637PubMedGoogle Scholar
  14. Berget SM, Moore C, Sharp PA (1977) Spliced segments at the 5′ terminus of adenovirus 2 late mRNA. Proc Nat Acad Sci USA 74: 3171–3175PubMedGoogle Scholar
  15. Berk AJ, Sharp PA (1978) Structure of the adenovirus 2 early mRNAs. Cell 14: 695–711PubMedGoogle Scholar
  16. Bhat BM, Wold WS (1986) Genetic analysis of mRNA synthesis in adenovirus region E3 at different stages of productive infection by RNA-processing mutants. J Virol 60: 54–63PubMedGoogle Scholar
  17. Bodnar JW, Hanson PI, Polvino-Bodnar M, Zempsky W, Ward DC (1989) The terminal regions of adenovirus and minute virus of mice DNAs are preferentially associated with the nuclear matrix in infected cells. J Virol 63: 4344–4353PubMedGoogle Scholar
  18. Bos JL, Polder LJ, Bernards R, Scrier PI, van den Elsen PJ, van der Eb AJ, van Ormondt H (1981) The 2.2 kb E1 b mRNA of human Ad12 and ad5 codes for two tumor antigens starting at different AUG triplets. Cell 27: 121–131PubMedGoogle Scholar
  19. Brady HA, Wold WSM (1988) Competition between splicing and polyadenylation reactions determines which adenovirus region E3 mRNAs are synthesized. Mol Cell Biol 8: 3291–3297PubMedGoogle Scholar
  20. Brady HA, Scaria A, Wold WSM (1992) Map of cis-acting sequences that determine alternative premessenger-RNA processing in the E3 complex transcription unit of adenovirus. J Virol 66: 5914–5923PubMedGoogle Scholar
  21. Bridge E, Ketner G (1989) Redundant control of adenovirus late gene expression by early region 4. J Virol 63: 631–638PubMedGoogle Scholar
  22. Bridge E, Ketner G (1990) Interaction of adenoviral E4 and E1b products in late gene expression. Virology 174: 345–353PubMedGoogle Scholar
  23. Bridge E, Hemstrom C, Pettersson U (1991) Differential regulation of adenovirus late transcription units by the products of early region 4. Virology 183: 260–266PubMedGoogle Scholar
  24. Bridge E, Carmo-Fonseca M, Lamond A, Pettersson U (1993) Nuclear organization of splicing small nuclear ribonucleoproteins in adenovirus-infected cells. J Virol 67: 5792–5802PubMedGoogle Scholar
  25. Chang DD, Sharp PA (1990) Messenger RNA transport and HIV rev regulation. Science 249: 614–615PubMedGoogle Scholar
  26. Chebli K, Gattoni R, Schmitt P, Hildwein G, Stevenin J (1989) The 216-nucleotide intron of the E1A pre-mRNA contains a hairpin structure that permits utilization of unusually distant branch acceptors. Mol Cell Biol 9: 4852–4861PubMedGoogle Scholar
  27. Chow LT, Broker TR (1978) The spliced structures of adenovirus 2 fiber message and the other late mRNAs. Cell 15: 497–510PubMedGoogle Scholar
  28. Chow LT, Gelinas RE, Broker TR, Roberts RJ (1977) An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA. Cell 12: 1–8PubMedGoogle Scholar
  29. Chow LT, Broker TR, Lewis JB (1979) Complex splicing patterns of RNAs from the early regions of adenovirus-2. J Mol Biol 134: 265–303PubMedGoogle Scholar
  30. Chroboczek J, Jacrot B (1987) The sequence of adenovirus fiber: similarities and differences between serotypes 2 and 5. Virology 161: 549–554PubMedGoogle Scholar
  31. Chroboczek J, Bieber F, Jacrot B (1992) The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2. Virology 186: 280–285PubMedGoogle Scholar
  32. Ciejek EM, Nordstrom JL, Tsai M-J, O’Malley BW (1982) Ribonucleic acid precursors are associated with the chick oviduct nuclear matrix. Biochemistry 21: 4945–4953PubMedGoogle Scholar
  33. Cladaras C, Wold WSM (1985) DNA sequence of the early E3 transcription unit of adenovirus 5. Virology 140: 28–43PubMedGoogle Scholar
  34. Cutt JR, Shenk T, Hearing P (1987) Analysis of adenovirus early region 4-encoded polypeptides synthesized in productively infected cells. J Virol 61: 543–552PubMedGoogle Scholar
  35. Delsert C, Morin N, Klessig DF (1989) Cis-acting elements and a trans-acting factor affecting alternative splicing of adenovirus L1 transcripts. Mol Cell Biol 9: 4364–4371PubMedGoogle Scholar
  36. DeZazzo JD (1990) Poly(A) site selection in the adenovirus type 2 major late transcription unit: processing and regulatory signals. PhD thesis, University of MichiganGoogle Scholar
  37. DeZazzo JD, Imperiale MJ (1989) Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit. Mol Cell Biol 9: 4951–4961PubMedGoogle Scholar
  38. DeZazzo JD, Falck-Pedersen E, Imperiale MJ (1991) Sequences regulating temporal poly(A) site switching in the adenovirus major late transcription unit. Mol Cell Biol 11: 5977–5984PubMedGoogle Scholar
  39. Dix I, Leppard KN (1993) Regulated splicing of adenovirus type 5 E4 transcripts and regulated cytoplasmic accumulation of E4 mRNA. J Virol 67: 3226–3231PubMedGoogle Scholar
  40. Dolph PJ, Racaniello V, Villamarin A, Palladino F, Schneider RJ (1988) The adenovirus tripartite leader eliminates the requirement for cap binding protein during translation initiation. J Virol 62: 2059–2066PubMedGoogle Scholar
  41. Dolph PJ, Huang J, Schneider RJ (1990) Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex. J Virol 64: 2669–2677PubMedGoogle Scholar
  42. Domenjoud L, Gallinaro H, Kister L, Meyer S, Jacob M (1991) Identification of a specific exon sequence that is a major determinant in the selection between a natural and a cryptic 5′ splice site. Mol Cell Biol 11: 4581–4590PubMedGoogle Scholar
  43. Dressier GR, Fraser NW (1987) DNA sequences downstream of the adenovirus type 2 fiber poly-adenylation site contain transcription termination signals. J virol 61: 2770–2776Google Scholar
  44. Dreyfuss G, Matunis MJ, Pinol-Roma S, Burd CG (1993) hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 62: 289–321Google Scholar
  45. Dunn AR, Hassel JA (1977) A novel method to map transcripts: evidence for homology between an adenovirus mRNA and discrete multiple regions of the viral genome. Cell 12: 23–36PubMedGoogle Scholar
  46. Evans R, Weber J, Ziff E, Darnell JE (1979) Premature termination during adenovirus transcription. Nature 278: 367–370PubMedGoogle Scholar
  47. Falck-Pedersen E, Logan J (1989) Regulation of poly(A) site selection in adenovirus. J Virol 63: 532–541PubMedGoogle Scholar
  48. Flint SJ, Beltz G, Linzer DIH (1983) Synthesis and processing of simian virus 40-specific RNA in adenovirus-infected, simian virus 40-transformed human cells. J Mol Biol 167: 335–359PubMedGoogle Scholar
  49. Fraser NW, Nevins JR, Ziff E, Darnell JE Jr (1979) The major late adenovirus type-2 transcription unit: termination is downstream from the last poly(A) site. J Mol Biol 129: 643–656PubMedGoogle Scholar
  50. Freyer GA, Katoh Y, Roberts RJ, (1984) Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing. Nucleic Acids Res 12: 3503–3519PubMedGoogle Scholar
  51. Gattoni R, Schmitt P, Stevenin J (1988) In vitro splicing of adenovirus E1A transcripts: characterization of novel reactions and of multiple branch points far from the 3′ splice site. Nucleic Acids Res 16: 2389–2409PubMedGoogle Scholar
  52. Gattoni R, Chebli K, Himmelspach M, Stevenin J (1991) Modulation of alternative splicing of adenoviral E1A transcripts: factors involved in the early-to-late transition. Genes Dev 5: 1847–1858PubMedGoogle Scholar
  53. Halbert DN, Cutt JR, Shenk T (1985) Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression and host cell shutoff. J Virol 56: 250–257PubMedGoogle Scholar
  54. Hales KH, Birk JM, Imperiale MJ (1988) Analysis of adenovirus type 2 L1 RNA 3′-end formation in vivo and in vitro. J Virol 62: 1464–1468PubMedGoogle Scholar
  55. Harper JE, Manley JL (1991) A novel protein factor is required for use of distal alternative 5′ splice sites in vitro. Mol Cell Biol 11: 5945–5953PubMedGoogle Scholar
  56. Harrison T, Graham F, Williams J (1977) Host-range mutants of adenovirus type 5 defective for growth in HeLa cells. Virology 77: 319–329PubMedGoogle Scholar
  57. Hasson TB, Soloway PD, Ornelles DA, Doerfler W, Shenk T (1989) Adenovirus L1 52- and 55-kilodalton proteins are required for assembly of virions. J Virol 63: 3612–3621PubMedGoogle Scholar
  58. Hayes BW, Telling GC, Myat MM, Williams JF, Flint SJ (1990) The adenovirus L4 100-kilodalton protein is necessary for efficient translation of viral late mRNA species. J Virol 64: 2732–2742PubMedGoogle Scholar
  59. Hemstrom C, Nordqvist K, Pettersson U, Virtanen A (1988) Gene product of region E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides. J Virol 62: 3258–3264PubMedGoogle Scholar
  60. Ho YS, Galos R, Williams J (1982) Isolation of type 5 adenovirus mutants with a cold sensitive host range phenotype: genetic evidence of an adenovirus transformation maintenance function. Virology 122: 109–124PubMedGoogle Scholar
  61. Huang J, Schneider RJ (1991) Adenovirus inhibition of cellular protein synthesis involves inactivation of cap binding protein. Cell 65: 271–280PubMedGoogle Scholar
  62. Huang M-M, Hearing P (1989) Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection. J Virol 63: 2605–2615PubMedGoogle Scholar
  63. Iwamoto S, Eggerding F, Falck-Pedersen E, Darnell JE Jr (1986) Transcription unit mapping in adenovirus: regions of termination. J Virol 59: 112–119PubMedGoogle Scholar
  64. Johnston JM, Anderson KP, Klessig DF (1985) Partial block to transcription of human adenovirus type 2 late genes in abortively infected monkey cells. J Virol 56: 378–385PubMedGoogle Scholar
  65. Ketner G, Bridge E, Virtanen A, Hemstrom C, Pettersson U (1989) Complementation of adenovirus E4 mutants by transient expression of E4 cDNA and deletion plasmids. Nucleic Acids Res 17: 3037–3048PubMedGoogle Scholar
  66. Kinloch R, Mackay N, Mautner V (1984) Adenovirus hexon: sequence comparision of subgroup C serotypes 2 and 5. J Biol Chem 259: 6431–6436PubMedGoogle Scholar
  67. Klessig D (1977) Two adenovirus messenger RNAs have a common 5′ terminal-leader sequence encoded at least 10kb upstream form their main coding regions. Cell 12: 9–12PubMedGoogle Scholar
  68. Kreivi J-P, Akusjarvi G (1994) Regulation of adenovirus alternative RNA splicing at the level of commitment complex formation. Nucleic Acids Res 22: 332–337PubMedGoogle Scholar
  69. Kreivi J-P, Zerivitz K, Akusjarvi G (1991) Sequences involved in the control of adenovirus L1 alternative RNA splicing. Nucleic Acids Res 19: 2379–2386PubMedGoogle Scholar
  70. Kumar A, Pederson T (1975) Comparison of proteins bound to heterogeneous nuclear RNA and messenger RNA in HeLa cells. J Mol Biol 96: 353–365PubMedGoogle Scholar
  71. Larsson S, Kreivi J-P, Akusjarvi G (1991) Control of adenovirus alternative RNA splicing: effect of viral DNA replication on splice site choice. Gene 107: 219–227PubMedGoogle Scholar
  72. Larsson S, Svensson C, Akusjarvi G (1992) Control of adenovirus major late gene expression at multiple levels. J Mol Biol 225: 287–298PubMedGoogle Scholar
  73. Le Moullec JM, Akusjarvi G, Stalhandske P, Pettersson U, Chambraud B, Gilardi P, Nasri M, Perricaudet M (1983) Polyadenylic acid addition sites in the adenovirus type 2 major late transcription unit. J Virol 48: 127–134PubMedGoogle Scholar
  74. Leppard KN (1993) Selective effects on adenovirus late gene expression of deleting the E1b 55K protein. J Gen Virol 74: 575–582PubMedGoogle Scholar
  75. Leppard KN, Shenk T (1989) The adenovirus E1B 55kd protein influences mRNA transport via an intranuclear effect on RNA metabolism. EMBO J 8: 2329–2336PubMedGoogle Scholar
  76. Leppard KN, Pilder S, Moore M, Logan J, Shenk T (1987) An adenovirus oncogene post-tran- scriptionally modulates mRNA accumulation. In: Kjeldgaard N, Forchhammer J (eds) Viral carcinogenesis. Alfred Benzon Symposium 24. Munksgaard, Copenhagen, pp 196–208Google Scholar
  77. Lewis JB, Anderson CW, Atkins JF (1977) Further mapping of late adenovirus genes by cell-free translation of RNA selected by hybridization to specific DNA fragments. Cell 12: 37–44PubMedGoogle Scholar
  78. Logan J, Shenk T (1984) Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection. Proc Natl Acad Sci USA 81: 3655–3659PubMedGoogle Scholar
  79. Logan J, Pilder S, Shenk T (1984) Functional analysis of the adenovirus type-5 early region 1B. Cancer Cells 2: 527–532Google Scholar
  80. Mandel JL (1989) Dystrophin: the gene and its product. Nature 339: 584–586PubMedGoogle Scholar
  81. Manley JL (1988) Polyadenylation of mRNA precursors. Biochim Biophys Acta 950: 1–12PubMedGoogle Scholar
  82. Manley JL, Sharp PA, Gefter ML (1982) RNA synthesis in isolated nuclei. Processing of adenovirus serotype 2 late messenger RNA precursors. J Mol Biol 159: 581–599PubMedGoogle Scholar
  83. Mann KP, Weiss EA, Nevins JR (1993) Alternative poly(A) site utilization during adenovirus infection coincides with a decrease in the activity of a poly(A) site processing factor. Mol Cell Biol 13: 2411–2419PubMedGoogle Scholar
  84. Mathews MB, Shenk T (1991) Adenovirus virus-associated RNA and translational control. J Virol 65: 5657–5662PubMedGoogle Scholar
  85. Mayeda A, Krainer AR (1992) Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 68: 365–375PubMedGoogle Scholar
  86. Mayeda A, Helfman DM, Krainer AR (1993) Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mol Cell Biol 13: 2993–3001PubMedGoogle Scholar
  87. McNally MT, Beemon K (1992) Intronic sequences and 3′ splice sites control Rous sarcoma virus RNA splicing. J Virol 66: 6–11PubMedGoogle Scholar
  88. Moen PT Jr, Fox E, Bodnar JW (1990) Adenovirus and minute virus of mice DNAs are localized at the nuclear periphery. Nucleic Acids Res 18: 513–520PubMedGoogle Scholar
  89. Montell C, Fisher EF, Caruthers MH, Berk AJ (1984) Control of adenovirus E1B mRNA synthesis by a shift in the activities of RNA splice sites. Mol Cell Biol 4: 966–972PubMedGoogle Scholar
  90. Moore MA, Shenk T (1988) The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells. Nucleic Acids Res 16: 2247–2262PubMedGoogle Scholar
  91. Moore M, Schaack J, Baim SB, Morimoto Rl, Shenk T (1987) Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells. Mol Cell Biol 7: 4505–4512PubMedGoogle Scholar
  92. Moore MJ, Query CC, Sharp PA (1993) Splicing of precursors to mRNAs by the spliceosome. In: Gesteland RF, Atkins JF (eds) The RNA world. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp 303–357Google Scholar
  93. Moyne G, Pichard E, Bernhard W (1978) Localization of simian adenovirus 7 (SA 7) transcription and replication in lytic infection. An ultracytochemical and autoradiographical study. J Gen Virol 40: 77–92PubMedGoogle Scholar
  94. Nevins JR, Darnell JE Jr (1978) Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell 15: 1477–1493PubMedGoogle Scholar
  95. Nevins JR, Wilson MC (1981) Regulation of adenovirus-2 gene expression at the level of transcriptional termination and RNA processing. Nature 290: 113–118PubMedGoogle Scholar
  96. Nevins JR, Ginsberg HS, Blanchard JM, Wilson MC, Darnell JE (1979) Regulation of the primary expression of the early adenovirus transcription units. J Virol 32: 727–733PubMedGoogle Scholar
  97. Nordqvist K, Akusjarvi G (1990) Adenovirus early region 4 stimulates mRNA accumulation via 5′ introns. Proc Natl Acad Sci USA 87: 9543–9547PubMedGoogle Scholar
  98. Nordqvist K, Ohman K, Akusjarvi G (1994) Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs. Mol Cell Biol 14: 437–445PubMedGoogle Scholar
  99. Ohman K, Nordqvist K, Akusjarvi G (1993) Two adenovirus proteins with redundant activities in virus growth facilitates tripartite leader mRNA accumulation. Virology 194: 50–58PubMedGoogle Scholar
  100. O’Malley RP, Duncan RF, Hershey JWB, Mathews MB (1989) Modification of protein synthesis initiation factors and the shut-off of host protein synthesis in adenovirus infected cells. Virology 168: 112–118PubMedGoogle Scholar
  101. Ornelles DA, ShenkT (1991) Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein. J Virol 65: 424–439PubMedGoogle Scholar
  102. Perricaudet M, Akusjarvi G, Virtanen A, Pettersson U (1979) Structure of two spliced mRNAs from the transforming region of human subgroup C adenoviruses. Nature 281: 694–696PubMedGoogle Scholar
  103. Perricaudet M, Le Moullec JM, Pettersson U (1980) Predicted structure of two adenovirus tumor antigens. Proc Natl Acad Sci USA 77: 3778–3782PubMedGoogle Scholar
  104. Pilder S, Leppard K, Logan J, Shenk T (1986a) Functional analysis of the adenovirus E1B 55K polypeptide. Cancer Cells 4: 285–290Google Scholar
  105. Pilder S, Moore M, Logan J, Shenk T (1986b) The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs. Mol Cell Biol 6: 470–476PubMedGoogle Scholar
  106. Popielarz M, Gattoni R, Stevenin J (1993) Contrasted cis-acting effects of downstream 5′ splice sites on the splicing of a retained intron: the adenoviral E1A pre-mRNA model. Nucleic Acids Res 21: 5144–5151PubMedGoogle Scholar
  107. Prescott JC, Falck-Pedersen E (1992) Varied poly(A) site efficiency in the adenovirus major late transcription unit. J Biol Chem 267: 8175–8181PubMedGoogle Scholar
  108. Reichel PA, Merrick WC, Skiekierka J, Mathews MB (1985) Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNA. Nature 313: 196–200PubMedGoogle Scholar
  109. Riley D, Flint SJ (1993) RNA binding properties of a translational activator, the adenovirus L4 100-kilodalton protein. J Virol 67: 3586–3595PubMedGoogle Scholar
  110. Roberts RJ, O’Neill K, Yen CT (1984) DNA sequences from the adenovirus 2 genome. J Biol Chem 259: 13968–13975PubMedGoogle Scholar
  111. Ross D, Ziff E (1992) Defective synthesis of early region 4 mRNAs during abortive adenovirus infections in monkey cells. J Virol 66: 3110–3117PubMedGoogle Scholar
  112. Sandler AB, Ketner G (1989) Adenovirus early region 4 is essential for normal stability of late nuclear RNAs. J Virol 63: 624–630PubMedGoogle Scholar
  113. Sarnow P, Hearing P, Anderson CW, Halbert DN, Shenk T, Levine AJ (1984) Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25 000-dalton protein in productively infected cells. J Virol 49: 692–700PubMedGoogle Scholar
  114. Scaria A, Wold WSM (1994) Fine-mapping of sequences that suppress splicing in the E3 complex transcription unit of adenovirus. Virology 205: 406–416PubMedGoogle Scholar
  115. Schmitt P, Gattoni R, Keohavong P, Stevenin J (1987) Alternative splicing of E1A transcripts of adenovirus requires appropriate ionic conditions in vitro. Cell 50: 31–39PubMedGoogle Scholar
  116. Schneider RJ, Weinberger C, Shenk T (1984) Adenovirus VA1 RNA facilitates the initiation of translation in virus infected cells. Cell 37: 291–298PubMedGoogle Scholar
  117. Schneider RJ, Safer B, Munemitsu S, Samuel CE, Shenk T (1985) Adenovirus VA1 RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection. Proc Natl Acad Sci USA 82: 4321–4324PubMedGoogle Scholar
  118. Schroder HC, Bachmann M, Diehl-Scifert B, Muller WEG (1987) Transport of mRNA from nucleus to cytoplasm. Prog Nucleic Acid Res Mol Biol 45: 98–142Google Scholar
  119. Shaw AR, Ziff EB (1980) Transcripts from the adenovirus-2 major late promoter yield a single early family of 3′ coterminal mRNAs and five late families. Cell 22: 905–916PubMedGoogle Scholar
  120. Smith CWJ, Patton JG, Nadal-Ginard B (1989) Alternative splicing in the control of gene expression. Annu Rev Genet 23: 527–577PubMedGoogle Scholar
  121. Soloway PD, Shenk T (1990) The adenovirus type 5 i-leader open reading frame functions in cis to reduce the half-life of L1 mRNAs. J Virol 64: 551–558PubMedGoogle Scholar
  122. Stephens C, Harlow E (1987) Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30kd and 35kd proteins. EMBO J 6: 2027–2035PubMedGoogle Scholar
  123. Svensson C, Akusjarvi G (1986) Defective RNA splicing in the absence of adenovirus-associated RNA I. Proc Natl Acad Sci USA 83: 4690–4694PubMedGoogle Scholar
  124. Symington JS, Lucher LA, Brackmann KH, Virtanen A, Pettersson U, Green M (1986) Biosynthesis of adenovirus type 2 i-leader protein. J Virol 57: 848–856PubMedGoogle Scholar
  125. Thimmappaya B, Weinberger C, Schneider RJ, Shenk T (1982) Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection. Cell 31: 543–351PubMedGoogle Scholar
  126. Thomas GP, Mathews MB (1980) DNA replication and the early to late transition in adenovirus infection. Cell 22: 523–532PubMedGoogle Scholar
  127. Tigges MA, Raskas HJ (1984) Splice junctions in adenovirus 2 early region 4 mRNAs: multiple splice sites produce 18 to 24 RNAs. J Virol 50: 106–117PubMedGoogle Scholar
  128. Tollefson AE, Scaria A, Saha SK, Wold WSM (1992) The 11 600-MW protein encoded by region E3 of adenovirus is expressed early but is greatly amplified at late stages of infection. J Virol 66: 3633–3642PubMedGoogle Scholar
  129. Ulfendahl PJ, Under S, Kreivi JP, Nordqvist K, Svensson C, Hultberg H, Akusjarvi G (1987) A novel adenovirus-2 E1A mRNA encoding a protein with transcription activation properties. EMBOJ 6: 2037–2044Google Scholar
  130. Van Ormondt H, Maat H, Van Beveren CP (1980) The nucleotide sequence of the transforming region E1 of adenovirus type 5 DNA. Gene 11: 299–309PubMedGoogle Scholar
  131. Virtanen A, Pettersson U (1985) Organization of early region 1B of human adenovirus type 2: identification of four differentially spliced mRNAs. J Virol 54: 383–391PubMedGoogle Scholar
  132. Virtanen A, Gilardi P, Naslund A, LeMoullec JM, Pettersson U, Perricaudet M (1984) mRNAs from human adenovirus 2 early region 4. J Virol 51: 822–831PubMedGoogle Scholar
  133. Wahle E, Keller W (1992) The biochemistry of 3′-end cleavage and polyadenylation of messenger RNA precursors. Annu Rev Biochem 61: 419–440PubMedGoogle Scholar
  134. Walton TH, Moen PT Jr, Fox E, Bodnar JW (1989) Interactions of minute virus of mice and adenovirus with host nucleoli. J Virol 63: 3651–3660PubMedGoogle Scholar
  135. Weinberg DH, Ketner G (1986) Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression. J Virol 57: 833–838PubMedGoogle Scholar
  136. Wickens M (1990) How the messenger got its tail: addition of poly(A) in the nucleus. Trends Biochem Sci 15: 277–281PubMedGoogle Scholar
  137. Williams J, Karger BD, Ho YS, Castiglia CL, Mann T, Flint SJ (1986) The adenovirus E1B 495R protein plays a role in regulating the transport and stability of the viral late messages. Cancer Cells 4: 275–284Google Scholar
  138. Wilson-Gunn SI, Kilpatrick JE, Imperiale MJ (1992) Regulated adenovirus mRNA 3′ end formation in a coupled in vitro transcription/processing system. J Virol 6: 5418–5424Google Scholar
  139. Wold WS, Gooding LR (1991) Region E3 of adenovirus: a cassette of genes involved in host immunosurveillance and virus-cell interactions. Virology 184: 1–8PubMedGoogle Scholar
  140. Yew Y, Kao CC, Berk AJ (1990) Dissection of functional domains in the adenovirus 2 early 1B 55K polypeptide by suppressor-linker insertional mutagenesis. Virology 179: 795–805PubMedGoogle Scholar
  141. Zamore PD, Patton JG, Green MR (1992) Cloning and domain structure of the mammalian splicing factor U2AF. Nature 355: 609–614PubMedGoogle Scholar
  142. Zerivitz K, Kreivi J-P, Akusjarvi G (1992) Evidence for a HeLa cell splicing activity that is necessary for activation of a regulated adenovirus 3′ splice site. Nucleic Acids Res 20: 3955–3961PubMedGoogle Scholar
  143. Zhang Y, Schneider RJ (1993) Adenovirus inhibition of cellular protein synthesis and the specific translation of late viral mRNAs. Semin Virol 4: 229–236Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Department of Microbiology and ImmunologyUniversity of Michigan Medical SchoolAnn ArborUSA
  2. 2.Department of Cell and Molecular BiologyKarolinska InstituteStockholmSweden
  3. 3.Department of Biological SciencesUniversity of WarwickCoventryUK

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