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The Mechanism of Adenovirus DNA Integration: Studies in a Cell-Free System

Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 199/2)

Abstract

The understanding of recombinative interactions between foreign (viral) DNA and mammalian DNA is of interest not only in tumor virology, gene therapy, and the generation of transgenic animals, but also for models about the possible evolutionary role of foreign DNA integration into established genomes. Foreign DNA can recombine with the host DNA in mammalian cells and thus become integrated into the cellular genome by what has been termed “nonhomologous recombination.” Nonhomologous recombination plays a central role in the biology of mammalian systems and is thought to be more common in mammalian cells than homologous recombination.

Keywords

Nuclear Extract Adenovirus Type Junction Site Autographa Californica Nuclear Polyhedrosis Virus Recombination Machinery 
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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Institut für GenetikCologne UniversityCologneGermany

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