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Expression, Nuclear Transport, and Phosphorylation of Adenovirus DNA Replication Proteins

Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 199/2)

Abstract

DNA tumor viruses have contributed immense wealth of knowledge in the past few years regarding the eukaryotic cellular processes involving replication, transcription, and translation. Adenoviruses (Ad) in particular have played a pioneering and significant role in the understanding of the mechanisms of many of these biological processes mainly due to the interaction of viral proteins with the host proteins during the virus life cycle. The development of the first cell-free system to study Ad DNA replication (Challberg and Kelly 1979; for reviews, see Challberg and Kelly 1989; Stillman 1989; Hay and Russell 1989) was pivotal to our current understanding of eukaryotic DNA replication.

Keywords

Nuclear Transport Adenovirus Type Recombinant Vaccinia Virus Cdc2 Kinase Nuclear Localization Signal Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Akiyama T, Ohuchi T, Sumida S, Matsumoto K, Toyoshima K (1992) Phosphorylation of the retinoblastoma protein by cdk2. Proc Natl Acad Sci USA 89: 7900–7904PubMedGoogle Scholar
  2. Alvarez E, Northwood IC, Gonzalez FA, Latour DA, Seth A, Abate C, Curran T, Davis RJ (1991) Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J Biol Chem 266: 15277–15285PubMedGoogle Scholar
  3. Anderson CW, Hardy MM, Dunn JJ, Klessig DF (1983) Independent, spontaneous mutants of adenovirus type 2-simian virus 40 hybrid Ad2+ND3 that grew efficiently in monkey cells possess identical mutations in the adenovirus type 2 DNA-binding protein gene. J Virol 48: 31–39PubMedGoogle Scholar
  4. Anderson CW, Samad A, Carroll RB (1986) Identification and characterization of the sites phosphorylated in the cellular tumor antigen p53 from SV40-transformed 3T3 cells and in the DNA-binding protein from adenovirus 2. In: Botchan M, Grodzicker T, Sharp PA (eds) DNA tumor viruses, p4. Cold Spring Harbor Press, Cold Spring Harbor, New York, pp 395–404Google Scholar
  5. Anderson KP, Klessig DF (1983) Posttranscriptional block to synthesis of a human adenovirus capsid protein in abortively infected monkey cells. J Mol Appl Genet 2: 31–43PubMedGoogle Scholar
  6. Ariga H, Klein A, Levine A, Horwitz M (1980) A cleavage product of the adenoviral DNA binding protein is active in DNA replication in vitro. Virology 101: 307–310PubMedGoogle Scholar
  7. Arrand JR, Roberts RJ (1979) The nucleotide sequences at the termini of adenovirus 2 DNA. J Mol Biol 128: 577–594PubMedGoogle Scholar
  8. Asselbergs FAM, Mathews MB, Smart JE (1983) Structural characterization of the proteins encoded by adenovirus early region 2A. J Mol Biol 163: 177–207PubMedGoogle Scholar
  9. Axelrod N (1978) Phosphoproteins of adenovirus type 2. Virology 87: 366–383PubMedGoogle Scholar
  10. Babich A, Nevins JR (1981) The stability of early adenovirus mRNA is controlled by the viral 72 kD DNA-binding protein. Cell 26: 371–379PubMedGoogle Scholar
  11. Biedenkapp H, Borgmeyer U, Sippel AE, Klempnauer KH (1988) Viral myb oncogene encodes a sequence specific DNA-binding activity. Nature 335: 835–837PubMedGoogle Scholar
  12. Blanco L, Bemad A, Blasco MA, Salas M (1991) A general structure for DNA-dependent DNA polymerases. Gene 100: 27–38PubMedGoogle Scholar
  13. Bodner JW, Hanson PI, Polvino-Bodner M, Zempsky W, Ward DC (1989) The terminal regions of adenovirus and minute virus of mice DNAs are preferentially associated with the nuclear matrix in infected cells. J Virol 63: 4344–4353Google Scholar
  14. Bohman D (1990) Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression. Cancer Cells 2: 337–344Google Scholar
  15. Bosher J, Robinson EC, Hay RT (1990) Direct interactions between the adenovirus type 2 DNA polymerase and the DNA binding domain of nuclear factor I. New Biol 2: 1083–1090PubMedGoogle Scholar
  16. Bosher J, Leith IR, Temperley SM, Wells M, Hay RT (1991) The DNA-binding domain of nuclear factor I is sufficient to cooperate with the adenovirus type 2 DNA-binding protein in viral DNA replication. J Gen Virol 72: 2975–2980PubMedGoogle Scholar
  17. Bosher J, Dawson A, Hay RT (1992) Nuclear factor I is specifically targeted to discrete subnuclear sites in adenovirus type 2-infected cells. J Virol 66: 3140 — 3150PubMedGoogle Scholar
  18. Boyle WJ, Smeal T, Defize LHK, Angel P, Woodgett JR, Karin M, Hunter T (1991) Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64: 573–584PubMedGoogle Scholar
  19. Branton PE, Evelegh M, Rowe DT, Graham FL, Bacchetti S (1985) Protein kinase and ATP-binding activity associated with the 72-kdalton single-stranded DNA-binding protein from early region 2A of human adenovirus type 5. Can J Biochem Cell Biol 63: 941–952PubMedGoogle Scholar
  20. Brigati DJ, Myerson D, Leary JJ, Spalholz B, Travis SZ, Fong CK, Hsiung GD, Ward DC (1983) Detection of viral genomes in cultured cells and parafilm-embedded tissue sections using biotin-labeled hybridization probes. Virology 126: 32–50PubMedGoogle Scholar
  21. Brough DE, Rice SA, Sell S, Klessig DF (1985) Restricted changes in the adenovirus DNA-binding protein that lead to extended host range or temperature-sensitive phenotype. J Virol 55: 206–212PubMedGoogle Scholar
  22. Brough DE, Drouguett G, Horwitz MS, Klessig DF (1993) Multiple functions of the adenovirus DNA-binding protein are required for efficient viral DNA synthesis. Virology 196: 269–281PubMedGoogle Scholar
  23. Cajean-Feroldi, Loeb J, Meguenni S, Girad M (1981) Protein kinase associated with the adenovirus single-stranded DNA-binding protein. Eur J Biochem 120: 79–87PubMedGoogle Scholar
  24. Cardenas ME, Walter R, Hanna D, Gasser SM (1993) CaScin kinase II copurifies with yeast DNA topoisomerase II and re-activates the dephosphorylated enzyme. J Cell Sci 104: 533–543PubMedGoogle Scholar
  25. Carter TH, Blanton RA (1978) Possible role of the 72,000-dalton in regulation of adenovirus type 5 early gene expression. J Virol 25: 664–674PubMedGoogle Scholar
  26. Cegielska A, Virshup DM (1993) Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase, caScin kinase I. Mol Cell Biol 13: 1202–1211PubMedGoogle Scholar
  27. Challberg MD, Kelly TJ (1979) Adenovirus DNA replication in vitro., Proc Natl Acad Sci USA 76: 655–659PubMedGoogle Scholar
  28. Challberg MD, Kelly TJ (1989) Animal virus DNA replication. Annu Rev Biochem 58: 671–717PubMedGoogle Scholar
  29. Challberg MD, Kelly TJ Jr (1981) Processing of the adenovirus terminal protein. J Virol 38: 272–277PubMedGoogle Scholar
  30. Challberg MD, Rawlins DR (1984) Template requirement for the initiation of adenovirus DNA replication. Proc Natl Acad Sci USA 81: 100–104PubMedGoogle Scholar
  31. Challberg MD, Desiderio SV, Kelly TJ (1980) Adenovirus DNA replication in vitro: characterization of a protein covalently linked to nascent DNA strands. Proc Natl Acad Sci USA 77: 5105–5109PubMedGoogle Scholar
  32. Chen M, Horwitz MS (1989) Dissection of functional domains of adenovirus DNA polymerase by linker insertion mutagenesis. Proc Natl Acad Sci USA 86: 6116–6120PubMedGoogle Scholar
  33. Chen M, Mermod N, Horwitz MS (1990) Protein-protein interactions between adenovirus DNA polymerase and nuclear factor I mediate formation of the DNA replication preinitiation complex. J Biol Chem 265: 18634–18642PubMedGoogle Scholar
  34. Chroboczek J, Bieber F, Jacrot (1992) The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2. Virology 186: 280–285Google Scholar
  35. Clark-Lewis I, Sanghera JS, Pelech SL (1991) Definition of a consensus sequence for peptide substrate recognition by p44mpk- the meiosis-activated myelin basic protein kinase. J Biol Chem 266: 15180–15184PubMedGoogle Scholar
  36. Cleat PH, Hay RT (1989) Co-operative interactions between NFI and the adenovirus DNA binding protein at the adenovirus origin of replication. EMBO J 8: 1841–1848PubMedGoogle Scholar
  37. Cleghon V, Klessig DF (1986) Association of the adenovirus DNA-binding protein with RNA both in vitro and in vivo. Proc Natl Acad Sci USA 83: 8947–8951PubMedGoogle Scholar
  38. Cleghon V, Klessig DF (1992) Characterization of the adenovirus DNA binding protein’s nucleic acid binding region by partial proteolysis and photochemical cross-linking. J Biol Chem 267: 7872–17881Google Scholar
  39. Cleghon V, Voelkerding K, Morin N, Delsert C, Klessig DF (1989) Isolation and characterization of a viable adenovirus mutant defective in nuclear transport of the DNA-binding protein. J Virol 63: 2289–2299PubMedGoogle Scholar
  40. De Robertis EM, Longthorne RF, Gurdon JB (1978) Intracellular migration of nuclear proteins in Xenopus oocytes. Nature 272: 254–256PubMedGoogle Scholar
  41. Desiderio SV, Kelly TJ Jr (1981) Structure of the linkage between adenovirus DNA and the 55,000 molecular weight terminal protein. J Mol Biol 145: 319–337PubMedGoogle Scholar
  42. De Vries E, Van Driel W, Tromp M, Van Boom J, Van der Vliet PC (1985) Adenovirus DNA replication in vitro: site-directed mutagenesis of the nuclear factor I binding site of the Ad2 origin. Nucleic Acids Res 13: 4935–4952PubMedGoogle Scholar
  43. De Vries E, Van Driel W, Bergsma WG, Arnberg AC, Van der Vliet PC (1989) HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J Mol Biol 208: 65–78PubMedGoogle Scholar
  44. Dingwall C (1991) Transport across the nuclear envelope: enigmas and explanations. Bioessays 13: 213–218PubMedGoogle Scholar
  45. Dingwall C, Laskey RA (1986) Protein import into the cell nucleus. Annu Rev Cell Biol 2: 367–390PubMedGoogle Scholar
  46. Dingwall C, Laskey RA (1991) Nuclear targeting sequences—a consensus? Trends Biochem Sci 16: J 478–481Google Scholar
  47. Dingwall C, Laskey RA (1992) The nuclear membrane. Science 258: 942–947PubMedGoogle Scholar
  48. Dingwall C, Sharnick SV, Laskey RA (1982) A polypeptide domain that specifies migration of nucleoplasms to the nucleus. Cell 30: 449–458PubMedGoogle Scholar
  49. Dobbs L, Zhao L-J, Sripad G, Padmanabhan R (1990) Mutational analysis of single-stranded DNA J templates active in the in vitro initiation assay for adenovirus DNA replication. Virology 178: 43–51Google Scholar
  50. Draetta G (1990) Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem Sci 15: 378–383PubMedGoogle Scholar
  51. Draetta G, Beach D (1988) Activation of cdc2 protein kinase during mitosis in human cells: cell-cycle-dependent phosphorylation and subunit rearrangement. Cell 54: 17–26PubMedGoogle Scholar
  52. Dutta A, Stillman B (1992) cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J 11: 2189–2199PubMedGoogle Scholar
  53. Eagle PA, Klessig DF (1992) A zinc-binding motif located between amino acids 273 and 286 in the adenovirus DNA-binding protein is necessary for ssDNA binding. Virology 187: 777–787PubMedGoogle Scholar
  54. Elroy-Stein O, Fuerst TR, Moss B (1989) Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5′ sequence improves the performance of the vaccinia virus/ bacteriophage T7 hybrid expression system. Proc Natl Acad Sci USA 86: 6126–6130PubMedGoogle Scholar
  55. Enomoto T, Lichy JH, Ikeda JE, Hurwitz J (1981) Adenovirus DNA replication in vitro: purification of the terminal protein in a functional form. Proc Natl Acad Sci USA 78: 6779–6783PubMedGoogle Scholar
  56. Faha B, Harlow E, Lees E (1993) The adenovirus E1A-associated kinase consists of cyclin E-p33cdck2 and cyclin A-p33cdck2. J Virol 67: 2456–2465PubMedGoogle Scholar
  57. Fanning E (1992) Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture. J Virol 66: 1289–1293PubMedGoogle Scholar
  58. Field J, Gronostajski RM, Hurwitz J (1984) Properties of the adenovirus DNA polymerase. J Biol Chem 259: 9487–9495PubMedGoogle Scholar
  59. Finlay DR, Meier E, Bradley P, Horecka J, Forbes DJ (1991) A complex of nuclear pore proteins required for pore function. J Cell Biol 114: 169–183PubMedGoogle Scholar
  60. Flint SJ, Sharp PA (1976) Adenovirus transcription. V. Quantitation of viral RNA sequences in adenovirus 2-infected and transformed cells. J Mol Biol 106: 749–771PubMedGoogle Scholar
  61. Fredman JN, Engler JA (1993) Adenovirus precursor to terminal protein interacts with the nuclear matrix in vivo and in vitro. J Virol 67: 3384–3395PubMedGoogle Scholar
  62. Freimuth PI, Ginsberg HS (1986) Codon insertion mutants of the adenovirus terminal protein. Proc Natl Acad Sci USA 83: 7816–7820PubMedGoogle Scholar
  63. Friefeld BR, Krevolin MD, Horwitz MS (1983) Effects of the adenovirus H5ts125 and H5ts107 DNA-binding proteins on DNA replication in vitro Virology 124: 380–389Google Scholar
  64. Fuerst TR, Moss B (1989) Structure and stability of mRNA synthesized by vaccinia virus-encoded bacteriophage T7 RNA polymerase in mammalian cells: importance of the 5′-untranslated leader. J Mol Biol 206: 333–348PubMedGoogle Scholar
  65. Garcia-Bustos J, Heitman J, Hall MN (1991) Nuclear protein localization. Biochim Biophys Acta 1071: 83–101PubMedGoogle Scholar
  66. Georgaki A, Hubscher U (1993) DNA unwinding by replication protein A is a property of the 70 kDa sübunit and is facilitated by phosphorylation of the 32 kDa subunit. Nucleic Acids Res 21: 3659–3665PubMedGoogle Scholar
  67. Gingeras TR, Sciaky D, Gelinas RE, Bing-Dong J, Yen CE, Kelly MM, Bullock PA, Parson BL, O’Neill KE, Roberts RJ (1982) Nucleotide sequences from the adenovirus-2 genome. J Biol Chem 257: 13475–13491PubMedGoogle Scholar
  68. Ginsberg HS, Ensinger MJ, Kauffman RS, Mayer AJ, Lundholm U (1974) Cell transformation: a study of regulation with type 5 and adenovirus temperature sensitive mutants. Cold Spring Harbor Symp Quant Biol 39: 419–426Google Scholar
  69. Ginsberg HS, Lundholm V, Linne T (1977) Adenovirus DNA binding proteins in cells infected with wild- type 5 adenovirus and two DNA-minus temperature sensitive mutants H5ts125 and H5ts149. J Virol 23: 142–151PubMedGoogle Scholar
  70. Giordano A, Lee JH, Scheppler JA, Herrmann C, Harlow E, Deuschle U, Beach D, Franza BR Jr (1991) Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. Science 253: 1271–1276PubMedGoogle Scholar
  71. Goldfarb DS (1989) Nuclear transport. Curr Opin Cell Biol 1: 441–446PubMedGoogle Scholar
  72. Goldfarb DS, Michaud N (1991) Pathways for the nuclear transport of proteins and RNAs. Trends Cell Biol 1: 20–24PubMedGoogle Scholar
  73. Gounari F, De Francesco R, Schmitt J, Van der Vliet PC, Cortese R, Stunnenberg H (1990) Amino-terminal domain of NF1 binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J 9: 559–566PubMedGoogle Scholar
  74. Green M, Symington J, Brackmann KH, Cartas MA, Thornton H, Young L (1981) Immunological and chemical identification of intracellular forms of adenovirus type 2 terminal protein. J Virol 40: 541–550PubMedGoogle Scholar
  75. Greenspan D, Palese P, Crystal M (1988) Two nuclear location signals in the influenza virus NS1 non-structural protein. J Virol 62: 3020–3026PubMedGoogle Scholar
  76. Handa H, Kingston RE, Sharp PA (1983) Inhibition of adenovirus early region IV transcription in vitro by a purified viral DNA binding protein. Nature 302: 545–547PubMedGoogle Scholar
  77. Hanover JA (1992) The nuclear pore: at the cross roads. FASEB J 6: 2288–2295PubMedGoogle Scholar
  78. Hard T, Kellenbach E, Boelens R, Maler BA, Dahlman K, Kreedman LP, Carlstedt-Duke J, Yamamoto KR, Gustafsson JA, Kaptein R (1990) Solution structure of the glucocorticoid receptor DNA-binding domain. Science 249: 157–160PubMedGoogle Scholar
  79. Hay RT, Rüssel WC (1989) Recognition mechanism in the synthesis of animal virus DNA. Biochem J 58: 3–16Google Scholar
  80. Herrmann C, Su L-K, Harlow E (1991) Adenovirus E1a is associated with a serine/threonine protein kinase. J Virol 65: 5848–5859PubMedGoogle Scholar
  81. Hope IA, Struhl K (1986) Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast. Cell 46: 885–894PubMedGoogle Scholar
  82. Horwitz MS (1978) Temperature-sensitive replication of H5ts125 adenovirus DNA in vitro. Proc Natl Acad Sci USA 75: 4291–4295PubMedGoogle Scholar
  83. Horwitz MS (1990) Adenoviridae and their replication. In: Fields BN, Knipe DM, Chanock RM et al. (eds) Virology, 2nd ed. Raven, New York, pp 1679–1721Google Scholar
  84. Hoss A, Moarefi I, Scheidtmann K-H, Cisek LJ, Corden JL, Dornreiter I, Arthur AK, Fanning E (1990) Altered phosphorylation pattern of simian virus 40 T antigen expressed in insect cells by using a baculovirus vector. J Virol 64: 4799–4807PubMedGoogle Scholar
  85. Hu Q, Lees JA, Buchkovich KJ, Harlow E (1992) The retinoblastoma protein physically associates with the human cdc2 kinase. Mol Cell Biol 12: 971–980PubMedGoogle Scholar
  86. Hunter T, Karin M (1992) The regulation of transcription by phosphorylation. Cell 70: 375–387PubMedGoogle Scholar
  87. Hurley JR, Dean AM, Sohl JL, Koshland DEJ, Stroud RM (1990) Regulation of enzyme by phosphorylation at the active site. Science 249: 1012–1016PubMedGoogle Scholar
  88. Imamoto N, Matsuoka Y, Kurihara T, Kohno K, Miyagi M, Sakiyama F, Okada Y, Tsunaswa S, Yoneda Y (1992) Antibodies against 70-KD heat shock cognate protein inhibit mediated nuclear import of karyophilic proteins. J Cell Biol 119: 1047–1061PubMedGoogle Scholar
  89. Jans DA, Ackermann M, Bischoff JR, Beach DH, Peters R (1991) p34cdc2-Mediated phosphorylation at T124 inhibits nuclear import of SV-40 T antigen proteins. J Cell Biol 115: 1203–1212Google Scholar
  90. Jeng YH, Wold WSM, Sugawara K, Gilead Z, Green M (1977) Adenovirus type 2 coded single-stranded DNA binding protein: in vivo phosphorylation and modification. J Virol 22: 402–411PubMedGoogle Scholar
  91. Johnston JM, Anderson KP, Klessig DF (1985) Partial block to transcription of human adenovirus type 2 late genes in abortively infected monkey cells. J Virol 56: 378–385PubMedGoogle Scholar
  92. Jones KA, Kodonaga JT, Rosenfeld PJ, Kelly TJ, Tijan R (1987) A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication. Cell 48: 79–89PubMedGoogle Scholar
  93. Joung I, Engler JA (1992) Mutations in two cysteine-histidinerich clusters in adenovirus type 2 DNA polymerase affect DNA binding. J Virol 66: 5788–5796PubMedGoogle Scholar
  94. Kalderon D, Richardson WD, Markham AF, Smith AE (1984a) Sequence requirements for nuclear location of simian virus 40 large-T antigen. Nature 311: 33–38Google Scholar
  95. Kalderon D, Roberts BL, Richardson WD, Smith AE (1984b) A short amino acid sequence able to specify nuclear location. Cell 39: 499–509Google Scholar
  96. Kaplan LM, Ariga H, Hurwitz J, Horwitz MS (1979) Complementation of the temperature-sensitive defect in H5ts125 adenovirus DNA replication in vitro. Proc Natl Acad Sci USA 76: 5534–5538PubMedGoogle Scholar
  97. Kawamura H, Nagata K, Masamune Y, Nakanishi Y (1993) Phosphorylation of NF-I in vitro by cdc2 kinase. Biochem Biophys Res Commun 192: 1424–1431PubMedGoogle Scholar
  98. Kedinger C, Brison O, Perrin F, Wilhelm J (1978) Structural analysis of viral replication intermediates isolated from adenovirus type-2 infected HeLa cell nuclei. J Virol 26: 364–379PubMedGoogle Scholar
  99. Kennelly PJ, Krebs EG (1991) Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem 266: 15555–15558PubMedGoogle Scholar
  100. Kenny M, Hurwitz J (1988) Initiation of adenovirus DNA replication II. Structural requirements using synthetic oligonucleotide adenovirus templates. J Biol Chem 263: 9809–9817PubMedGoogle Scholar
  101. Kitagawa M, Saitoh S, Ogino H, Okabe T, Matsumoto H, Okuyama A, Tamai K, Ohba Y, Yasuda H, Nishimura S, Taya Y (1992) cdc2-Like kinase is associated with the retinoblastoma protein. Oncogene 7: 1067–1074PubMedGoogle Scholar
  102. Klein H, Maltzman W, Levine AJ (1979) Structure-function relationships of the adenovirus DNA-binding protein. J Biol Chem 254: 11051–11060PubMedGoogle Scholar
  103. Kleinberger T, Shenk T (1991) A protein kinase is present in a complex with adenovirus E1A proteins. Proc Natl Acad Sci USA 88: 11143–11147PubMedGoogle Scholar
  104. Klessig DF, Anderson CW (1975) Block of multiplication of adenovirus serotype 2 in monkey cells. J Virol 16: 1650–1668PubMedGoogle Scholar
  105. Klessig DF, Grodzicker T (1979) Mutations that allow human Ad2 and Ad5 to express late genes on monkey cells map in the viral gene encoding the 72K DNA-binding protein. Cell 17: 957–966PubMedGoogle Scholar
  106. Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philipe M, Roberts JM (1991) Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66: 1217–1228PubMedGoogle Scholar
  107. Kraiss S, Barnekow A, Montenarh M (1990) Protein kinase activity associated with immunopurified p53 protein. Oncogene 5: 845–855PubMedGoogle Scholar
  108. Krevolin MD, Horwitz MS (1987) Functional interactions of the domains of the adenovirus DNA-binding protein. Virology 156: 167–170PubMedGoogle Scholar
  109. Kusukawa J, Ramachandra M, Nakano R, Padmanabhan R (1994) Phosphorylation-dependent interaction of adenovirus preterminal protein with the viral origin of DNA replication. J Biol Chem 269: 2189–2196PubMedGoogle Scholar
  110. Lanford RE, Butel JS (1984) Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen. Cell 37: 801–813PubMedGoogle Scholar
  111. Lanford RE, Kanda P, Kennedy RC (1986) Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal. Cell 46: 575–582PubMedGoogle Scholar
  112. Leegwater PAJ, Van Driel W, Van der Vliet PC (1985) Recognition site of nuclear factor I, a sequence-specific DNA-binding protein from HeLa cells that stimulates adenovirus DNA replication. EMBO J 4: 1515–1521PubMedGoogle Scholar
  113. Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E (1992) The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J 10: 4279–4290Google Scholar
  114. Leith IR, Hay RT, Russel WC (1989) Adenovirus subviral particles and cores can support limited DNA replication. J Gen Virol 70: 3235–3248PubMedGoogle Scholar
  115. Leopald P, O’Farrell PH (1991) An evolutionary conserved cyclin homolog from Drosophila rescues yeast deficient in G1 cyclins. Cell 66: 1207–1216Google Scholar
  116. Levine AJ, Van der Vliet PC, Sussenbach J (1976) The replication of papovavirus and adenovirus DNA. Curr Top Microbiol Immunol 73: 68–124Google Scholar
  117. Levinson A, Levine AJ (1977) The isolation and identification of the adenovirus group C tumor antigens. Virology 76: 1–11PubMedGoogle Scholar
  118. Levinson AD, Postel EH, Levine AJ (1977) In vivo and in vitro phosphorylation of the adenovirus type 5 single strand-specific DNA-binding protein. Virology 79: 144–159PubMedGoogle Scholar
  119. Lew DJ, Dulic V, Reed SI (1991) Isolation of three novel cyclins by rescue of G1 cyclin (cln) function in yeast. Cell 66: 1197–1206PubMedGoogle Scholar
  120. Lewis JB, Atkins JF, Baum PR, Solen R, Gesteland RF, Anderson CW (1976) Location and identification of the genes for adenovirus type 2 early polypeptide. Cell 7: 141–151PubMedGoogle Scholar
  121. Lichy JH, Field J, Horwitz MS, Hurwitz J (1982) Separation of adenovirus terminal protein precursor from its associated DNA polymerase: role of both proteins in the initiation of adenovirus DNA replication. Proc Natl Acad Sci USA 79: 5225–5229PubMedGoogle Scholar
  122. Lindenbaum JO, Field J, Hurwitz J (1986) The adenovirus DNA binding protein and adenovirus DNA polymerase interact to catalyze elongation of primed templates. J Biol Chem 261: 10218–10227PubMedGoogle Scholar
  123. Linne T, Philipson L (1980) Further characterization of the phosphate moiety of the adenovirus type 2 DNA-binding protein. Eur J Biochem 103: 259–270PubMedGoogle Scholar
  124. Linne T, Jornvall H, Philipson L (1977) Purification and characterization of the phosphorylated DNA-binding protein from adenovirus type 2 infected cells. Eur J Biochem 76: 481–490PubMedGoogle Scholar
  125. Lucknow VA, Summers MD (1988) Trends in the development of baculovirus expression vectors. Biotechnology 6: 47–55Google Scholar
  126. Ma J, Ptashne M (1987) Deletion analysis of GAL4 defines two transcriptional activating segments. Cell 48: 847–853PubMedGoogle Scholar
  127. Mailer JL (1990) Xenopus oocytes and the biochemistry of cell division. Biochemistry 29: 3157–3166Google Scholar
  128. Mann R (1987) Identification and characterization of phosphorylation sites of adenovirus (Ad2) DNA-binding protein (DBP). Ph D thesis, New York University, New YorkGoogle Scholar
  129. Matsushime H, Roussel MF, Ashmun RA, Sherr CJ (1991) Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701–713PubMedGoogle Scholar
  130. Matsuura Y, Possee RD, Overton HA, Bishop DHL (1987) Baculovirus expression vectors: the requirements of high level expression of proteins including glycoproteins. J Gen Virol 69: 1233–1250Google Scholar
  131. McPherson RA, Ginsberg HS, Rose JA (1982) Adeno-associated virus helper activity of adenovirus DNA binding protein. J Virol 44: 666–673PubMedGoogle Scholar
  132. McVey D, Brizuela L, Mohr I, Marshak DR, Gluzman J, Beach D (1989) Phosphorylation of large tumor antigen by cdc2 kinase stimulates SV40 DNA replication. Nature 341: 503–507PubMedGoogle Scholar
  133. McVey D, Ray S, Gluzman Y, Berger L, Wildman AG, Marshak DR, Tegtmeyer P (1993) cdcl phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen. J Virol 67: 5206–5215Google Scholar
  134. Mermod N, O’Neill EA, Kelly TJ, Tjian R (1989) The proline-rich transcriptional activator of CTF/NFI-I is distinct from the replication and DNA binding domain. Cell 58: 741–753PubMedGoogle Scholar
  135. Meyerson M, Enders GH, Wu C, Su L, Gorka C, Nelson C, Harlow E, Tsai L (1992) A family of human cdc2-related protein kinases. EMBO J 11: 2909–2917PubMedGoogle Scholar
  136. Miller LK (1988) Baculovirus as gene expression vectors. Annu Rev Microbiol 42: 177–199PubMedGoogle Scholar
  137. Mittanacht S, Weinberg RA (1991) G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment. Cell 65: 381–393Google Scholar
  138. Moarefi IF, Small D, Gilbert I, Hopfner M, Randall SK, Schneider C, Russo AA, Ramsperger U, Arthur AK, Stahl H, Kelly TJ, Fanning E (1993) Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV 40) large T antigen specifically blocks SV 40 origin DNA unwinding. J Virol 67: 4992–5002PubMedGoogle Scholar
  139. Mohr IJ, Stillman B, Gluzman Y (1987) Regulation of SV40 DNA replication by phosphorylation of T antigen. EMBO J 6: 153–160PubMedGoogle Scholar
  140. Moreland RB, Langevin GL, Singer RH, Garcea RL, Hereford LM (1987) Amino acid sequences that determine the nuclear localization of yeast histone 2B. Mol Cell Biol 7: 4048–4057PubMedGoogle Scholar
  141. Moreno S, Nurse P (1990) Substrates for p34cdc2: in vivo Veritas? Cell 61: 549–551PubMedGoogle Scholar
  142. Morin N, Delsert C, Klessig DF (1989a) Nuclear localization of the adenovirus DNA-binding protein: requirement for two signals and complementation during viral infection. Mol Cell Biol 9: 4372–4380PubMedGoogle Scholar
  143. Morin N, Delsert C, Klessig DF (1989b) Mutations that affect phosphorylation of the adenovirus DNA-binding protein alters its ability to enhance its own synthesis. J Virol 63: 5228–5237PubMedGoogle Scholar
  144. Moss B (1991) Vaccinia virus: a tool for research and vaccine development. Science 252: 1662–1667PubMedGoogle Scholar
  145. Moss B, Elroy-Stein T, Mizukami T, Alexander WA, Fuerst TR (1990) New mammalian expression vectors (product review). Nature 348: 91–92PubMedGoogle Scholar
  146. Mul YM, Van der Vliet PC (1992) Nuclear factor I enhances adenovirus DNA replication by increasing the stability of a preinitiation complex. EMBO J 11: 751–760PubMedGoogle Scholar
  147. Mul YM, Verrijzer CP, Van der Vliet PC (1990) Transcription factors NFI and NFIII/Oct-I function independently employing different mechanisms to enhance adenovirus DNA replication. J Virol 64: 5510–5518PubMedGoogle Scholar
  148. Mul YM, Verrijzer CP, Van der Vliet PC(1993) Adenovirus DNA binding protein effects the kinetics of DNA replication by a mechanism distinct from NFI or oct I. Nucleic Acids Res 21: 641–647PubMedGoogle Scholar
  149. Murti KG, Davis DS, Kitchingman GR (1990) Localization of adenovirus-encoded DNA replication protein in the nucleus by immunogold electron microscopy. J Gen Virol 71: 2847–2857PubMedGoogle Scholar
  150. Nagata K, Guggenheimer RA, Enomoto T, Lichy JH, Hurwitz J (1982) Adenovirus DNA replication in vitro: identification of a host factor that stimulates synthesis of the preterminal protein-dCMP complex. Proc Natl Acad Sci USA 79: 6438–6442PubMedGoogle Scholar
  151. Nagata K, Guggenheimer RA, Hurwitz J (1983a) Adenovirus DNA replication in vitro: synthesis of full-length DNA with purified proteins. Proc Natl Acad Sci USA 80: 4266–4270PubMedGoogle Scholar
  152. Nagata K, Guggenheimer RA, Hurwitz J (1983b) Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA. Proc Natl Acad Sci USA 80: 6177–6181PubMedGoogle Scholar
  153. Nakamura H, Marita T, Sato C (1986) Structural organization of replicon domains during DNA synthetic phase in the mammalian nucleus. Exp Cell Res 165: 291–297PubMedGoogle Scholar
  154. Nakano R, Zhao L-J, Padmanabhan R (1991) Overproduction of adenovirus DNA polymerase and preterminal protein in HeLa cells. Gene 105: 173–178PubMedGoogle Scholar
  155. Nasheuer H-P, Moore A, Wahl AF, Wang TSF (1991) Cell cycle-dependent phosphorylation of human DNA polymerase a. J Biol Chem 266: 7893–7903PubMedGoogle Scholar
  156. Nasheuer HP, von Winkler D, Schneider C, Dornreiter I, Gilbert I, Fanning E (1992) Purification and functional characterization of bovine RP-A in an in vitro SV40 DNA replication system. Chromosoma 102: S52–S59PubMedGoogle Scholar
  157. Nath ST, Nayak DP (1990) Function of two discrete regions is required for nuclear localization of polymerase basic protein 1 of A/WSN/33 influenza virus (H1 N1). Mol Cell Biol 10: 4139–4145PubMedGoogle Scholar
  158. Neale GAM, Kitchingman GR (1990) Conserved region 3 of the adenovirus type 5 DNA-binding protein is important for interaction with single-stranded DNA. J Virol 64: 630–638PubMedGoogle Scholar
  159. Newmeyer DD, Forbes DJ (1988) Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocation. Cell 52: 641–653PubMedGoogle Scholar
  160. Nicolas JC, Sarnow P, Girad M, Levine AJ (1983) Host range, temperature-conditional mutants in the adenovirus DNA binding protein are defective in the assembly of infectious virus. Virology 126: 228–239PubMedGoogle Scholar
  161. Nigg EA, Baeuerle PA, Luhrmann R (1991) Nuclear import-export: in search of signals and mechanisms. Cell 66: 15–22PubMedGoogle Scholar
  162. O’Neill EA, Kelly TJ (1988) Purification and characterization of nuclear factor III (origin recognition protein C) a sequence-specific DNA binding protein required for efficient initiation of adenovirus DNA replication. J Biol Chem 263: 931–937PubMedGoogle Scholar
  163. O’Neill EA, Fletcher C, Burrow CR, Heintz N, Roeder RG, Kelly TJ (1988) Transcriptional factor OTF-1 is functionally identical to the DNA replication factor NF III. Science 241: 1210–1213PubMedGoogle Scholar
  164. Ostrove JM, Rosenfeld P, Williams J, Kelly TJ Jr (1983) In vitro complementation as an assay for purification of adenovirus DNA replication proteins. Proc Natl Acad Sci USA 80: 935–939PubMedGoogle Scholar
  165. Pagano M, Draetta G, Jansen-Durr P (1992a) Association of cdk2 kinase with the transcription factor E2F during S phase. Science 255: 1144–1147PubMedGoogle Scholar
  166. Pagano M, Pepperkok R, Verde F, Ansorje W, Draetta G (1992b) cyclin A is required at two points in the human cell cycle. EMBO J 11: 961–971Google Scholar
  167. Paris J, Le Guellec R, Couturier A, Le Guellec K, Omilli F, Camonis J, MacNeill S, Philippe M (1991) Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2. Proc Natl Acad Sci USA 88: 1039–1043PubMedGoogle Scholar
  168. Pearson RB, Kemp BE (1991) Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations. Methods Enzymol 200: 62–81PubMedGoogle Scholar
  169. Peck VM, Gerner EW, Cress AE (1993) A DNA polymerase a-associated 56 kDa protein kinase. Biochem Biophys Res Commun 190: 325–331PubMedGoogle Scholar
  170. Pelech SL, Sanghera JS (1992) Mitogen-activated protein kinases: versatile transducers for cell signaling. Trends Biochem Sci 17: 233–238PubMedGoogle Scholar
  171. Peters R (1986) Fluorescence microphotolysis to measure nucleocytoplasmic transport and intracellular mobility. Biochim Biophys Acta 864: 305–359PubMedGoogle Scholar
  172. Pettit SC, Horwitz MS, Engler JA (1988) Adenovirus preterminal protein synthesized in COS cells from cloned DNA is active in DNA replication in vitro. J Virol 62: 496–500PubMedGoogle Scholar
  173. Picard D, Yamamoto KR (1987) Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 6: 3333–3340PubMedGoogle Scholar
  174. Pines J, Hunter T (1989) Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in cell cycle and for interaction with p34cdc2. Cell 58: 833–846PubMedGoogle Scholar
  175. Postel E, Klein H, Levine AJ (1978) The fidelity of phosphorylation of the adenovirus DNA-binding protein by an in vitro nuclear protein kinase from virus-infected cells. Virology 86: 291–294PubMedGoogle Scholar
  176. Prevelige P Jr, Fasman GD (1989) Chou-Fasman Prediction of the secondary structure of proteins: Chou-Fasman-Prevelige algorithm. In: Fasman GD (ed) Prediction of protein structure and the principles of protein conformation. Plenum, New York, pp 391Google Scholar
  177. Prives C (1990) The replication functions of SV40 T antigen are regulated by phosphorylation. Cell 61: 735–738PubMedGoogle Scholar
  178. Pruijn GJM, Van Driel W, Van der Vliet PC (1986) Nuclear factor III, a novel sequence-specific DNA-binding protein from HeLa cells stimulating adenovirus DNA replication. Nature 322: 656–659PubMedGoogle Scholar
  179. Pruijn GJM, Van Driel W, Van Miltenburg RT, Van der Vliet PC (1987) Promoter and enhancer elements containing a conserved sequence motif are recognized by nuclear factor III, a protein stimulating adenovirus DNA replication. EMBO J 6: 3771–3778PubMedGoogle Scholar
  180. Puvion-Dutilleul F (1991) Simultaneous detection of highly phosphorylated proteins and viral major DNA binding protein distribution in nuclei of adenovirus type 5-infected HeLa cells. J Histochem Cytochem 39: 669–680PubMedGoogle Scholar
  181. Puvion-Dutilleul F, Puvion E (1990a) Replicating single-stranded adenovirus type 5 DNA molecules accumulate within well-delimited intranuclear areas of lytically infected HeLa cells. Eur J Cell Biol 379–388Google Scholar
  182. Puvion-Dutilleul F, Puvion E (1990b) Analysis by in situ hybridization and autoradiography of sites of replication and storage of single- and double-stranded adenovirus type 5 DNA in lytically infected HeLa cells. J Struct Biol 103: 280–289PubMedGoogle Scholar
  183. Quinlan MP, Chen LB, Knipe DM (1984) The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell 36: 857–868PubMedGoogle Scholar
  184. Ramachandra M, Padmanabhan R (1993) Adenovirus DNA polymerase is phosphorylated by a stably associated histone H1 kinase. J Biol Chem 268: 17448–17456PubMedGoogle Scholar
  185. Ramachandra M, Nakano R, Mohan PM, Rawitch AB, Padmanabhan R (1993) Adenovirus DNA polymerase is a phosphoptrotein. J Biol Chem 268: 442–445PubMedGoogle Scholar
  186. Rawlins DR, Rosenfeld PJ, Wides RJ, Challberg MD, Kelly TJ Jr (1984) Structure and function of the adenovirus origin of DNA replication. Cell 37: 309–319PubMedGoogle Scholar
  187. Rekosh DMK, Russel WC, Bellett AJD, Robinson AJ (1977) Identification of a protein linked to the ends of adenovirus DNA. Cell 11: 283–295PubMedGoogle Scholar
  188. Rice SA, Klessig DF (1984) The function(s) provided by the adenovirus-specified, DNA-binding protein required for viral late gene expression is independent of the role of the protein in viral DNA replication. J Virol 49: 35–49PubMedGoogle Scholar
  189. Richardson WD, Roberts BL, Smith AE (1986) Nuclear location signals in polyoma virus large-T. Cell 44: 77–85PubMedGoogle Scholar
  190. Richardson WD, Mills AD, Dilworth SM, Laskey RA, Dingwall C (1988) Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell 52: 655–664PubMedGoogle Scholar
  191. Rihs HP, Peters R (1989) Nuclear transport kinetics depend on phosphorylation-site-containing sequences flanking the karyophilic signal of the simian virus 40 T antigen. EMBO J 8: 1479–1484PubMedGoogle Scholar
  192. Rihs H-P, Jans DA, Fan H, Peters R (1991) The rate of nuclear cytoplasmic protein transport is determined by the caScin kinase II site flanking the nuclear localization sequence of the SV 40 T-antigen. EMBO J 10: 633–639PubMedGoogle Scholar
  193. Robbins J, Dilworth SM, Laskey RA, Dingwall C (1991) Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell 64: 615–623PubMedGoogle Scholar
  194. Roberts B (1989) Nuclear location signal-mediated protein transport. Biochim Biophys Acta 1008: 263–280PubMedGoogle Scholar
  195. Roberts SB, Segil N, Heintz N (1991) Differential phosphorylation of the transcription factor oct1 during the cell cycle. Science 253: 1022–1026PubMedGoogle Scholar
  196. Roninson I, Padmanabhan R (1980) Studies on the nature of the linkage between the terminal protein and the adenovirus DNA. Biochem Biophys Res Commun 94: 398–405PubMedGoogle Scholar
  197. Roovers DJ, Van der Lee FM, Van der Wees J, Sussenbach JS (1993) Analysis of the adenovirus type 5 terminal protein precursor and DNA polymerase by linker insertion mutagenesis. J Virol 67: 265–276PubMedGoogle Scholar
  198. Rosenblatt J, Gu Y, Morgan DO (1992) Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc Natl Acad Sci USA 89: 2824–2828PubMedGoogle Scholar
  199. Rosenwirth B, Anderson CW, Levine AJ (1976) Tryptic finger printing analysis of adenovirus 2, 5 and 12 DNA-binding proteins. Virology 69: 617–625PubMedGoogle Scholar
  200. Russell WC, Blair GE (1977) Polypeptide phosphorylation in adenovirus-infected cells. J Gen Virol 34: 19–35PubMedGoogle Scholar
  201. Russell WC, Webster A, Leith IR, Kemp GD (1989) Phosphorylation of adenovirus DNA-binding protein. J Gen Virol 70: 3249–3259PubMedGoogle Scholar
  202. Saborio J, Oberg B (1976) In Vivo and in vitro synthesis of adenovirus type 2 early proteins. J Virol 17: 865–875PubMedGoogle Scholar
  203. Sasaguri Y, Sanford T, Aguirre P, Padmanabhan R (1987) Immunological analysis of 140-kDa adenovirus-encoded DNA polymerase in adenovirus type-2 infected HeLa cells using antibodies raised against the protein expressed in E. coli. Virology 160: 389–399Google Scholar
  204. Schaack J, Schedl P, Shenk T (1990a) Topoisomerase I and II cleavage of adenovirus DNA in vitro: both topoisomerase activities appear to be required for adenovirus DNA replication. J Virol 64: 78–85PubMedGoogle Scholar
  205. Schaak J, Ho WY, Freimuth P, Shenk T (1990b) Adenovirus terminal protein mediates both nuclear matrix attachment and efficient transcription of adenovirus DNA. Genes Dev 4: 1197–1208Google Scholar
  206. Schechter NM, Davies W, Anderson CW (1980) Adenovirus coded deoxyribonucleic acid binding protein: isolation physical properties and effects of proteolytic digestion. Biochemistry 19: 2802–2810PubMedGoogle Scholar
  207. Scheidtman KH, Buck M, Schneider J, Kalderson D, Fanning E, Smith AE (1991) Biochemical characterization of phosphorylation site mutants of simian virus 40 large T antigen: evidence for interaction between amino and carboxy-terminal domains. J Virol 65: 1479–1490Google Scholar
  208. Schneider J, Fanning E (1988) Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA binding specificity for sites I and II affects SV40 DNA replication activity. J Virol 62: 1598–1605PubMedGoogle Scholar
  209. Segil N, Roberts SB, Heintz N (1991a) Mitotic phosphorylation of the Oct-1/POU homeodomain and regulation of Oct-1 DNA binding activity. Science 254: 1814–1816PubMedGoogle Scholar
  210. Segil N, Roberts SB, Heintz N (1991b) Cell-cycle-regulated phosphorylation of the transcription factor oct-1. Cold Spring Harb Symp Quant Biol 56: 285–292PubMedGoogle Scholar
  211. Shi Y, Thomas JO (1992) The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate. Mol Cell Biol 12: 2186–2192PubMedGoogle Scholar
  212. Shinagawa M, Padmanabhan R (1979) Nucleotide sequence at the inverted terminal repetition of adenovirus type 2 DNA. Biochem Biophys Res Commun 87: 671–678PubMedGoogle Scholar
  213. Shinagawa M, Padmanabhan R (1980) Comparitive sequence analysis of the inverted terminal repetitions from different adenoviruses. Proc Natl Acad Sci USA 77: 3931–3935Google Scholar
  214. Shu L, Hong JS, Wei Y-F, Engler JA (1986) Nucleotide sequence of the genes encoded in early region 2b of human adenovirus type 12. Gene 46: 187–195PubMedGoogle Scholar
  215. Shu L, Horwitz MS, Engler JA (1987) Expression of enzymatically active adenovirus DNA polymerase from cloned DNA requires sequences upstream of the main open reading frame. Virology 161: 520–526PubMedGoogle Scholar
  216. Shu L, Pettit SC, Engler JA (1988) The precise structure and coding capacity of mRNAs from early region 2B of human adenovirus serotype 2. Virology 165: 348–356PubMedGoogle Scholar
  217. Silver PA (1991) How proteins enter the nucleus. Cell 64: 489–497PubMedGoogle Scholar
  218. Simmons DT, Chou W, Rodgers K (1986) Phosphorylation downregulates the DNA-binding activity of simian virus 40 antigen. J Virol 60: 888–894PubMedGoogle Scholar
  219. Smart JE, Stillman BW (1982) Adeovirus terminal protein precursor: partial amino acid sequence and the site of covalent linkage to virus DNA. J Biol Chem 257: 13499–13506PubMedGoogle Scholar
  220. Sobczak-Thepot J, Harper F, Florentin Y, Zindy F, Brechot C, Puvion E (1993) Localizaion of cyclin A at the sites of cellular DNA replication. Exp Cell Res 206: 43–48PubMedGoogle Scholar
  221. Sprang SR, Acharya KR, Goldsmith EJ, Stuart DI, Varvill K, Fletterick RJ, Madsen NB, Johnson LN (1988) Structural changes in glycogen Phosphorylase induced by phosphorylation. Nature 336: 215–221PubMedGoogle Scholar
  222. Starr CM, Hanover JA (1990) Structure and function of the nuclear pore complex: new perspectives. Bioessays 12: 323–330PubMedGoogle Scholar
  223. Stillman BW (1981) Adenovirus DNA replication in vitro: a protein linked to the 5′ end of nascent DNA strands. J Virol 37: 139–147PubMedGoogle Scholar
  224. Stillman B (1989) Initiation of eukaryotic DNA replication in vitro. Annu Rev Cell Biol 5: 197–245PubMedGoogle Scholar
  225. Stillman BW, Lewis JB, Chow LT, Mathews MB, Smart JE (1981) Identification of the gene and mRNA for the adenovirus terminal protein precursor. Cell 23: 497–508PubMedGoogle Scholar
  226. Stillman BW, Topp WC, Engler JA (1982) Conserved sequences at the origin of adenovirus DNA replication. J Virol 44: 530–537PubMedGoogle Scholar
  227. Stuiver MH, Van der Vliet PC (1990) Adenovirus DNA binding protein forms multimeric protein complex with double-stranded DNA and enhances binding of nuclear factor I. J Virol 64: 379–386PubMedGoogle Scholar
  228. Stunnenberg HG, Lange H, Philipson L, Van Miltenberg RT, Van der Vliet PC (1988) High expression of functional adenovirus DNA polymerase and precursor terminal protein using recombinant vaccinia virus. Nucleic Acids Res 16: 2431–2444PubMedGoogle Scholar
  229. Sturm RA, Herr W (1988) The POU domain DNA-binding structure. Nature 336: 601–604PubMedGoogle Scholar
  230. Sturzbecher H-W, Maimets T, Chumakov P, Brain R, Addison C, Simanis V, Rudge K, Philp R, Grimaldi M, Court W, Jenkins JR (1990) p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis. Oncogene 5: 795–801Google Scholar
  231. Sugawara K, Gilead Z, Green M (1977) Purification and molecular characterization of a adenovirus type 2 DNA-binding protein. J Virol 21: 338–346PubMedGoogle Scholar
  232. Tamura K, Kanaoka Y, Jinno S, Nagata A, Ogiso Y, Shimizu K, Hayakawa T, Nojima H, Okayama H (1993) Cyclin G: a new mammalian cyclin with homology to fission yeast Cig 1. Oncogene 8: 2113–2118PubMedGoogle Scholar
  233. Tanaka M, Herr W (1990) Differential transcriptional activation by oct-1, and oct-2: interdependent activation domains induce oct-2 phosphorylation. Cell 60: 375–386PubMedGoogle Scholar
  234. Temperley SM, Hay RT (1992) Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins. EMBO J 11: 761–768PubMedGoogle Scholar
  235. Templeton DJ (1992) Nuclear binding of retinoblastoma gene product is determined by cell cyle-regulated phosphorylation. Mol Cell Biol 12: 435–443PubMedGoogle Scholar
  236. Thomas G (1992) MAP kinase by any other name smells just as sweet. Cell 68: 3–6PubMedGoogle Scholar
  237. Tokunaga O, Shinagawa M, Padmanabhan R (1982) Physical mapping of the genome and sequence analysis at the inverted terminal repetition of adenovirus type 4 DNA. Gene 18: 329–334PubMedGoogle Scholar
  238. Tolun A, Alestrom P, Pettersson U (1979) Sequence of inverted terminal repetitions from different adenoviruses: demonstration of conserved sequences and homology between SA-7 termini and SV40 DNA. Cell 17: 705–713PubMedGoogle Scholar
  239. Tommasino M, Adamczewski JP, Carlotti F, Barth CF, Manetti R, Contorni M, Cavalieri F, Hunt T, Crawford L (1993) HPV 16 E7 protein associates with the protein kinase p33cdkl and cyclin A. Oncogene 8: 195–202PubMedGoogle Scholar
  240. Tsai LH, Harlow E, Meyerson M (1991) Isolation of the human cdk2 gene that encodes the cyclin A and adenovirus E1A-associated p33 kinase. Nature 353: 174–177PubMedGoogle Scholar
  241. Tsernoglou D, Tsugita A, Tucker AD, Van der Vliet PC (1985) Characterization of the chymotryptic core of the adenovirus DNA-binding protein. FEBS Lett 188: 248–252PubMedGoogle Scholar
  242. Underwood MR, Fried HM (1990) Characterization of nuclear localizing sequences derived from yeast ribosomal protein L29. EMBO J 9: 91–99PubMedGoogle Scholar
  243. Van Bergen BGM, Van der Vliet PC (1983) Temperature sensitive initiation and elongation of adenovirus DNA replication in vitro with nuclear extracts from H5ts36- H5ts149- and H5ts125-infected HeLa cells. J Virol 46: 624–648Google Scholar
  244. Van der Vliet PC (1990) Adenovirus DNA replication in vitro. In: Strauss PR, Wilson SH (eds) The eukaryotic nucleus, vol 1. Telford, Caldwell pp 1–29Google Scholar
  245. Van der Vliet PC, Levine AJ (1973) DNA-binding proteins specific for cells infected by adenovirus. Nature 246: 170–174Google Scholar
  246. Van der Vliet PC, Sussenbach JS (1975) An adenovirus type 5 gene function required for initiation of viral DNA replication.Virology 67: 415–426Google Scholar
  247. Van der Vliet PC, Zandberg J, Jansz HS (1977) Evidence for a function of the adenovirus DNA binding protein in initiation of DNA synthesis as well as in elongation on nascent DNA chains. Virology 80: 98–110PubMedGoogle Scholar
  248. Van der Vliet PC, Keegstra W, Jansz HS (1978) Complex formation between the adenovirus type 5 DNA binding protein and single-stranded DNA. Eur J Biochem 86: 389–398PubMedGoogle Scholar
  249. Verrijzer CP, Kal AJ, Van der Vliet PC (1990) DNA binding domain (POU domain) of transcription factor oct-1 suffices for stimulation of DNA replication. EMBO J 9: 1883–1888PubMedGoogle Scholar
  250. Voelkerding K, Klessig DF (1986) Identification of two nuclear subclasses of the adenovirus type 5 encoded DNA-binding protein. J Virol 60: 353–362PubMedGoogle Scholar
  251. Watson CJ, Hay RT (1990) Expression of adenovirus type 2 DNA polymerase in insect cells infected with a recombinant baculovirus. Nucleic Acids Res 18: 1167–1173PubMedGoogle Scholar
  252. Weinberg RA (1991) Tumor suppressor genes. Science 254: 1138–1146PubMedGoogle Scholar
  253. Wides RJ, Challberg MD, Rawlins DR, Kelly TJ (1987) Adenovirus origin of DNA replication: sequence requirements for replication in vitro. Mol Cell Biol 7: 864–874PubMedGoogle Scholar
  254. Wilcock D, Lane DP (1991) Localization of p53, retinoblastoma and host replication proteins at sites of viral DNA replication in herpes-infected cells. Nature 349: 429–431PubMedGoogle Scholar
  255. Williams KR, Chase J (1990) Eukaryotic single-stranded nucleic acid binding proteins. In: Revzin A (ed) The biology of nonspecific DNA-protein interactions. CRC, Boca Raton, pp 197–227Google Scholar
  256. Williams RT, Carbonaro-Hall DA, Hall FL (1992) Copurification of p34ccfc2/p58 cyclin A proline-directed protein kinase and the retinoblastoma tumor susceptibility gene product: interaction of an oncogenic serine/threonine protein kinase with a tumor-suppressor protein. Oncogene 7: 423–432PubMedGoogle Scholar
  257. Xiong Y, Connolly T, Futcher B, Beach D (1991) Human D-type cyclin. Cell 65: 691–699PubMedGoogle Scholar
  258. Xiong Y, Zhang H, Beach D (1992) D type cyclin associates with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71: 505–514PubMedGoogle Scholar
  259. Zhao L-J (1990) Expression and nuclear transport of the adenovirus DNA polymerase and preterminal protein. PhD Thesis, University of Kansas, Kansas City, p 66Google Scholar
  260. Zhao L-J, Padmanabhan R (1988) Nuclear transport of adenovirus DNA polymerase is facilitated by interaction with preterminal protein. Cell 55: 1005–1015PubMedGoogle Scholar
  261. Zhao L-J, Padmanabhan R (1991) Three basic regions in adenovirus DNA polymerase interact differentially depending on the protein context to function as bipartite nuclear localization signals. New Biol 3: 1074–1088PubMedGoogle Scholar
  262. Zhao L-J, Irie K, Trirawatanapong T, Nakano R, Nakashima A, Morimatsu M, Padmanabhan R (1991) Synthesis of biologically active adenovirus preterminal protein in insect cells using a baculovirus vector. Gene 100: 147–154PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Kansas Medical CenterKansas CityUSA

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