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Molecular Interactions During Adenovirus DNA Replication

Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 199/2)

Abstract

Over the past 20 years studies on the replication of adenovirus DNA have contributed not only to an understanding of the mechanics of adenovirus DNA replication, but have also shed light on basic processes such as the assembly of nucleoprotein complexes and virus-host interactions. This subject has been reviewed extensively (Hay and Russell 1989; Stillman 1989; Van Der Vliet 1990; Salas 1991), but a number of recent findings have suggested that the time may be ripe for further evaluation of new developments in the field.

Keywords

Adenovirus Type Preinitiation Complex Terminal Protein Adenovirus Genome Deoxycytidine Monophosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Adhya S, Schneidman Hurwitz J (1986) Reconstruction of adenovirus replication origins with a human Nuclear factor 1 binding site. J biol chem 261: 3339–3346PubMedGoogle Scholar
  2. Bemad A, Zaballos A, Salas M, Blanco L (1987) Structural and functional relationships between procaryotic and eukaryotic DNA polymerases. EMBO J 6: 4219–4225Google Scholar
  3. Bemad A, Blanco L, Lazaro JM, Martin G, Salas M (1989) A conserved 3′-5′ exonuclease active site in prokaryotic and eukaryotic DNA polymerases. Cell 59: 219–228Google Scholar
  4. Boehmer PE, Lehman IR (1993) Herpes simplex virus type IICP8: helix-destabilising properties. J Virol 67: 711–715PubMedGoogle Scholar
  5. Bosher J, Robinson EC, Hay RT (1990) Interactions between the adenovirus type 2 polymerase and the DNA binding domain of nuclear factor I. New Biol 2: 1083–1090PubMedGoogle Scholar
  6. Bosher J, Leith IR, Temperley SM, Wells M, Hay RT (1991) The DNA-binding domain of nuclear factor I is sufficient to cooperate with the adenovirus type 2 DNA-binding protein in viral replication. J Gen Virol 72: 2975–2980PubMedGoogle Scholar
  7. Challberg MD, Kelly TJ (1979) Adenovirus DNA replication in vitro. Proc Natl Acad Sci USA 76: 655–659PubMedGoogle Scholar
  8. Challberg MD, Rawlins DR (1984) Template requirements for the initiation of adenovirus DNA replication. Proc Natl Acad Sci USA 81: 100–104PubMedGoogle Scholar
  9. Challberg MD, Desiderio SV, Kelly TJ (1980) Adenovirus DNA replication in vitro: characterisation of a protein covalently linked to nascent DNA strands. Proc Natl Acad Sci USA 77: 5105–5109Google Scholar
  10. Chen M, Mermod N, Horwitz MS (1990) Protein-protein interactions between adenovirus DNA polymerase and nuclear factor I mediate formation of the DNA replication pre-initiation complex. J Biol Chem 265: 18634–18642PubMedGoogle Scholar
  11. Cleat PH, Hay RT (1989) Co-operative interactions between NF-I and the adenovirus DNA binding protein at the origin of DNA replication. EMBO J 8: 1841–1848PubMedGoogle Scholar
  12. Cleghorn V, Klessig DF (1992) Characterisation of the nucleic acid binding region of adenovirus DNA binding protein by partial proteolysis and photochemical cross-linking. J Biol Chem 267: 17872–17881Google Scholar
  13. De Vries E, van Driel W, Tromp M, van Boom J, Van der Vliet PC (1985) Adenovirus DNA replication in vitro: site directed mutagenesis of the nuclear factor I binding site of the Ad. origin. Nucleic Acids Res 13: 4943–4952Google Scholar
  14. De Vries E, van Driel W, van den Heuvel SJL, Van der Vliet PC (1987) Contact point analysis of the HeLa nuclear factor I recognition site reveals symmetrical binding at one side of the helix. EMBO J 6: 161–168PubMedGoogle Scholar
  15. Eagle PA, Klessig DF (1992) A zinc-binding motif located between amino acids 273 and 286 in the adenovirus DNA-binding protein is necessary for ssDNA binding. Virology 187: 777–787PubMedGoogle Scholar
  16. Enomoto T, Lichy JH, Ikeda JE, Hurwitz J (1981) Adenovirus replication in vitro: Purification of the terminal protein in a functional form. Proc Natl Acad Sci USA 78: 6779–6783PubMedGoogle Scholar
  17. Field J, Gronostajski RM, Hurwitz J (1984) Properties of the adenovirus DNA polymerase. J Biol Chem 259: 9487–9495PubMedGoogle Scholar
  18. Fredman JN, Engler JA (1993) Adenovirus precursor to terminal protein interacts with the nuclear matrix in vivo and in vitro. J Virol 67: 3384–3395PubMedGoogle Scholar
  19. Fredman JN, Pettit SC, Horwitz MS, Engler JA (1991) Linker insertion mutations in the adenovirus preterminal protein that affect DNA replication in vivo and in vitro. J Virol 65: 4591–4597PubMedGoogle Scholar
  20. Freimuth PI, Ginsberg HS (1986) Codon insertion mutants of the adenovirus terminal protein. Proc Natl Acad Sci USA 83: 7816–7820PubMedGoogle Scholar
  21. Friefeld BR, Krevolin MD, Horwitz MS (1983) Effect of the adenovirus H5ts125 and Hts107 DNA binding proteins on DNA replication in vitro. Virology 124: 380–389PubMedGoogle Scholar
  22. Georgaki A, Hubscher U (1993) DNA unwinding by replication factor A is a property of the 70KDa subunit and is facilitated by phosphorylation of the 32KDa subunit. Nucleic Acids Res 21: 3659–3665PubMedGoogle Scholar
  23. Georgaki A, Strack B, Podust V, Hubscher U (1992) DNA unwinding activity of replication protein A. FEBS Lett 308: 240–244PubMedGoogle Scholar
  24. Gounari F, De Francesco R, Schmitt J, Van der Vliet PC, Cortese R, Stunnenberg H (1990) Amino terminal domain of NF-I binds to DNA as a dimer and activates adenovirus DNA replication. EMBO J 9: 559–566PubMedGoogle Scholar
  25. Guggenheimer RA, Nagata K, Kenny M, Hurwitz J (1984) Protein primed replication of plasmids containing the terminus of the adenovirus genome 2: purification and characterisation of a host protein required for the replication of DNA templates devoid of the terminal protein. J Biol Chem 259: 7815–7825PubMedGoogle Scholar
  26. Harris MPG, Hay RT (1988) DNA sequences required for the initiation of adenovirus type 4 DNA replication J Mol Biol 201: 57–67PubMedGoogle Scholar
  27. Hay RT (1985a) The origin of adenovirus DNA replication: minimal DNA sequence in vivo. EMBO J 4: 421–426PubMedGoogle Scholar
  28. Hay RT (1985b) The origin of adenovirus DNA replication: role of the nuclear factor I site in vivo. J Mol Biol 186: 129–136PubMedGoogle Scholar
  29. Hay RT, McDougall IM (1986) Viable viruses with deletions in the left inverted terminal repeat define the origin of Ad2 DNA replication. J Gen Virol 6: 321–332Google Scholar
  30. Hay RT, Russell WC (1989) Recognition mechanisms in the synthesis of animal virus DNA’s. Biochem J 258: 3–16PubMedGoogle Scholar
  31. Hay RT, Stow ND, McDougall IM (1984) Replication of adenovirus mini chromosomes. J Mol Biol 175: 493–510PubMedGoogle Scholar
  32. Hay RT, Clark L, Cleat PH, Harris MPG, Robertson EC, Watson CJ (1988) Requirements for the initiation of adenovirus types 2 and 4 DNA replication. Cancer Cells 6: 71–75Google Scholar
  33. Huberman JA, Kornberg A (1971) Stimulation of T4 bacteriophage DNA polymerase by the protein product of gene 32. J Mol Biol 62: 39–52PubMedGoogle Scholar
  34. Ikeda J-E, Enomoto T, Hurwitz J (1982) Adenovirus protein primed initiation of DNA chains in vitro. Proc Natl Acad Sci USA 79: 2442–2446PubMedGoogle Scholar
  35. Jones KA, Kadonaga JT, Rosenfeld PJ, Kelly TJ, Tjian R (1987) A cellular DNA binding protein that activates eukaryotic transcription and DNA replication. Cell 48: 79–89PubMedGoogle Scholar
  36. Joung I, Engler JA (1992) Mutations in two cysteine-histidine-rich clusters in adenovirus type 2 DNA polymerase affect DNA binding. J Virol 66: 5788–5796PubMedGoogle Scholar
  37. Kenny MK, Hurwitz J (1988) Initiation of adenovirus DNA replication. II. Structural requirements using synthetic oligonucleotide adenovirus templates. J Biol Chem 263: 9801–9808PubMedGoogle Scholar
  38. Kenny MK, Balogh LA, Hurwitz J (1988) Initiation of adenovirus DNA replication. I. Mechanism of action of a host protein required for replication of adenovirus DNA templates devoid of the terminal protein. J Biol Chem 263: 9809–9817PubMedGoogle Scholar
  39. Kenny MK, Lee S-H, Hurwitz J (1989) Multiple functions of human single-stranded DNA binding protein in simian virus 40 DNA replication: single-strand stabilisation and stimulation of DNA polymerases a and 5. Proc Natl Acad Sci USA 86: 9757–9761PubMedGoogle Scholar
  40. Kenny MK, Schlegel U, Furneaux H, Hurwitz J (1990) The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication. J Biol Chem 265: 7693–7700PubMedGoogle Scholar
  41. Kitchingman GR (1985) Sequence of the DNA binding protein of a human subgroup E adenovirous (type 4): comparisons with subgroup A (type 12), subgroup B (type 7) and subgroup C (type 5). Virology 146: 90–101PubMedGoogle Scholar
  42. Klein H, Maltzman W, Levine AJ (1979) Structure function relationships of the adenovirus DNA binding protein. J Biol Chem 254: 11051–11060PubMedGoogle Scholar
  43. Kruijer W, van Schaik FAM, Sussenbach JS (1981) Structure and organisation of the gene coding for the DNA binding protein of adenovirus type 5. Nucleic Acids Res 9: 4439–4450PubMedGoogle Scholar
  44. Lally C, Dorper T, Groger W, Antoine G, Winnacker E-L (1984) A size analysis of the adenovirus replicon. EM BO J 3: 333–337Google Scholar
  45. Larder BA, Kemp SD, Darby G (1987) Related functional domains in virus DNA polymerases. EMBO J 6: 169–175PubMedGoogle Scholar
  46. Leegwater PAJ, van Driel W, Van der Vliet PC (1985) Recognition site of nuclear factor I, a sequence specific DNA binding protein from HeLa cells that stimulates adenovirus DNA replication. EMBO J 4: 1515–1521PubMedGoogle Scholar
  47. Lichy JH, Field J, Horwitz MS, Hurtwitz J (1981) Formation of a covalent complex between the 80kDa adenovirus terminal protein and 5′-dCMP in vitro. Proc Natl Acad Sci USA 78: 2678–2682PubMedGoogle Scholar
  48. Lichy JH, Field J, Horwitz MS, Hurwitz J (1982) Separation of the adenovirus terminal protein precursor from its associated DNA polymerase: role of both proteins in the initiation of adenovirus DNA replication. Proc Natl Acad Sci USA 79: 5225–5229PubMedGoogle Scholar
  49. Lindenbaum JO, Field J, Hurwitz J (1986) The adenovirus DNA binding protein and adenovirus DNA polymerase interact to catalyse elongation of primed DNA templates. J Biol Chem 261: 10218–10227PubMedGoogle Scholar
  50. Mangel WF, McGrath WJ, Toledo D, Anderson CW (1993) Viral DNA and a viral peptide are cofactors of adenovirus virion proteinase activity. Nature 361: 274–275PubMedGoogle Scholar
  51. Marcy Al, Yager DR, Coen DM (1990) Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among a-like DNA polymerases is involved in substrate recognition. J Virol 64: 2208–2216PubMedGoogle Scholar
  52. Meisterernst M, Rogge L, Foeckler R, Karaghiosoff M, Winnacker E-L (1989) Structural and functional organisation of a porcine gene coding for nuclear factor I. Biochemistry 28: 8191–8200PubMedGoogle Scholar
  53. Mermod N, O’Neill EA, Kelly TJ, Tjian R (1989) The proline rich transcriptional activator of CTF/NF-I is distinct from the replication and DNA binding domain. Cell 58: 741–753PubMedGoogle Scholar
  54. Monaghan A, Hay RT (1994) Pyridoxal phosphate inhibition of the adenovirus DNA polymerase. (submitted for publication) Monaghan A, Webster AG, Hay RT (1994) Adenovirus DNA binding protein: helix destabilising property. Nucleic Acids Res 5: 742–748Google Scholar
  55. Mul YM, Van der Vliet PC (1992) Nuclear factor I enhances Adenovirus DNA replication increasing the stability of a preinitiation complex. EMBO J 11: 751–760PubMedGoogle Scholar
  56. Mul YM, Van der Vliet PC (1993) The adenovirus DNA binding protein effects the kinetics of DNA replication by a mechanism distinct from NF-I or Oct-1. Nucleic Acids Res 21: 641–647PubMedGoogle Scholar
  57. Mul YM, Verrijzer CP, Van der Vliet PC (1990) Transcription factors NF-I and NF-III/Oct-1 function independently, employing different mechanisms to enhance adenovirus DNA replication. J Virol 64: 5510–5518PubMedGoogle Scholar
  58. Nagata K, Guggenheimer RA, Enomoto T, Lichy JH, Hurwitz J (1982) Adenovirus DNA replication in vitro: identification of a host factor that stimulates synthesis of the preterminal protein-dCMP complex. Proc Natl Acad Sci USA 79: 6438–6442PubMedGoogle Scholar
  59. Nagata K, Guggenheimer RA, Hurwitz J (1983) Specific binding of acellular DNA replication protein to the origin of replication of adenovirus DNA. Proc Natl Acad Sci USA 80: 6177–6181PubMedGoogle Scholar
  60. Neale GAM, Kitchingman GR (1990) Conserved region 3 of the adenovirus type 5 DNA binding protein is important for interaction with single-stranded DNA. J Virol 64: 630–638PubMedGoogle Scholar
  61. O’Neill EA, Kelly TJ (1988) Purification and characterisation of nuclear factor III (origin recognition protein C), a sequence specific DNA binding protein required for efficient initiation of adenovirus DNA replication. J Biol Chem 263: 931–937PubMedGoogle Scholar
  62. O’Neill EA, Fletcher C, Burrow CR, Heintz N, Roeder RG, Kelly TJ (1988) The transcription factor OTF-1 is functionally identical to the adenovirus DNA replication factor NF-III. Science 241: 1210–1213PubMedGoogle Scholar
  63. Paonessa G, Gounari F, Frank R, Cortese R (1988) Purification of an NFI-like binding protein from rat liver and cloning of the corresponding cDNA. EMBO J 7: 3115–3123PubMedGoogle Scholar
  64. Pettit SC, Horwitz MS, Engler JA (1988) Adenovirus preterminal protein synthesised in COS cells from cloned DNA is active in DNA replication in vitro. J Virol 62: 496–500PubMedGoogle Scholar
  65. Pettit SC, Horwitz MS, Engler JA (1989) Mutations in the precursor to the terminal protein of adenovirus serotypes 2 and 5. J Virol 63: 5344–5350Google Scholar
  66. Pronk R, Van der Vliet PC (1993) The adenovirus terminal protein influences binding of replication proteins and changes the origin structure. Nucleic Acids Res 21: 2293–2300PubMedGoogle Scholar
  67. Pronk R, Stuiver MH, Van der Vliet PC (1992) Adenovirus DNA replication: the function of the covalently bound terminal protein. Chromosoma 102, 39–45Google Scholar
  68. Pruijin GJM, Van Driel W, Van der Vliet PC (1986) A novel sequence specific DNA binding protein from HeLa cells stimulating adenovirus DNA replication. Nature 322: 656–659Google Scholar
  69. Pruijin GJM, Van der Vliet PC, Dathan NA, Mattaj IW (1989) Anti-OTF-1 antibodies inhibit NF-III stimulation in vitro adenovirus DNA replication. Nucleic Acids Res 17: 1845–1863Google Scholar
  70. Ramachandra M, Padmanabhan R (1993) Adenovirus DNA polymerase is phosphorylated by a stably associated histone H1 kinase. J Biol Chem 268: 17448–17456PubMedGoogle Scholar
  71. Ramachandra M, Nakano R, Mohan PM, Rawitch AB, Padmanabhan P (1993) Adenovirus DNA polymerase is a phosphoprotein. J Biol Chem 268: 442–448PubMedGoogle Scholar
  72. Rancourt C, Tihanyi K, Bourbonniere M, Weber JM (1994) Identification of active-site residues of the adenovirus endopeptidase. Proc Natl Acad Sci USA 91: 844–847PubMedGoogle Scholar
  73. Rawlins DR, Rosenfeld PJ, Wides RJ, Challberg MD, Kelly TJ (1984) Structure and function of the adenovirus origin of DNA replication. Cell 37: 309–319PubMedGoogle Scholar
  74. Reuben RC, Getter MC (1973) A DNA-binding protein induced by bacteriophage T7. Proc Natl Acad Sci USA 70: 1864–1870Google Scholar
  75. Roovers DJ, van der Lee FM, van der Wees J, Sussenbach JS (1993) Analysis of the adenovirus type 5 terminal protein precursor and DNA polymerase by linker insertion mutagenesis. J Virol 67: 265–276PubMedGoogle Scholar
  76. Rosenfeld PJ, O’Neil, EA, Wides RJ, Kelly TJ (1987) Sequence specific interactions between cellular DNA-binding proteins and the adenovirus origin of replication. Mol Cell Biol 7: 875–886PubMedGoogle Scholar
  77. Salas M (1991) Protein-priming of DNA replication. Annu Rev Biochem 60: 39–71PubMedGoogle Scholar
  78. Santoro C, Mermod N, Andrews PC, Tjian R (1988) A family of human CCAAT box binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNA’s. Nature 334: 218–224PubMedGoogle Scholar
  79. Schaak J, Yew-Hai Ho W, Freimuth P, Shenk T (1990) Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA. Genes Dev 4: 1197–1208Google Scholar
  80. Schneider R, Gander I, Muller U, Mertz R, Winnacker EL (1986) A sensitive and rapid gel retention assay for nuclear factor I and other DNA binding proteins in crude nuclear extracts. Nucl Acid Res 14: 1303–1317Google Scholar
  81. Shu L, Horwitz MS, Engler JA (1987) Expression of enzymatically active adenovirus DNA polymerase from cloned cDNA requires sequences upstream of the main open reading frame. Virology 161: 520–526PubMedGoogle Scholar
  82. Stillman B (1989) Initiation of eukaryotic DNA replication in vitro. Annu Rev Cell Biol 5: 197–245PubMedGoogle Scholar
  83. Stillman B, Lewis JB, Chow LT, Mathews MB, Smart JE (1981) Identification of the gene and mRNA for the adenovirus terminal protein precursor. Cell 23: 497–508PubMedGoogle Scholar
  84. Stillman B, Tamanoi F, Matthews MB (1982) Purification of an adenovirus-coded DNA polymerase that is required for initiation of DNA replication. Cell 31: 613–623PubMedGoogle Scholar
  85. Stow ND (1982) The infectivity of adenovirus genomes lacking DNA sequence from their left hand termini. Nucleic Acids Res 10: 5105–5119PubMedGoogle Scholar
  86. Strum RA, Herr W (1988) The POU domain is a bipartite DNA-binding structure. Nature 336: 601–604Google Scholar
  87. Strum RA, Das G, Herr W (1988) The ubiquitous octamer binding protein oct-1 contains a POU domain and a homeobox subdomain. Genes Dev 2: 1582–1599Google Scholar
  88. Stuiver MH, Van der Vliet PC (1990) Adenovirus DNA binding protein forms a multimeric protein complex with double-stranded DNA and enhances binding of nuclear factor I. J Virol 65: 379–389Google Scholar
  89. Stuiver MH, Bergsma WG, Arnberg AC, Van Amerongen H, Van Grondelle R, Van der Vliet PC (1992) Structural alterations of double-stranded DNA in a complex with the adenovirus DNA-binding protein: implications for its function in DNA replication. J Mol Biol 225: 99–1011Google Scholar
  90. Stunnberg HG, Lange H, Philipson L. Van Miltenburg RT, Van der Vliet PC (1988) High expression of functional adenovirus DNA polymerase and precursor terminal protein using recombinant vaccinia virus. Nucleic Acids Res 16: 2431–2444Google Scholar
  91. Tarmanoi F, Stillman B (1982) Function of adenovirus terminal protein in the initiation of DNA replication. Proc Natl Acad Sci USA 79: 2221–2225Google Scholar
  92. Tamanoi F, Stillman B (1983) Initiation of adenovirus DNA replication in vitro requires a specific DNA sequence. Proc Natl Acad Sci USA 80: 6446–6450PubMedGoogle Scholar
  93. Temperley SM, Hay RT (1991) Replication of adenovirus type 4 DNA by a purified fraction from infected cells. Nucleic Acids 19: 3243–3249Google Scholar
  94. Tempereley SM, Hay RT (1992) Recognition of the adenovirus type 2 origin of replication by the virally encoded DNA polymerase and preterminal proteins. EMBO J 11: 761–768Google Scholar
  95. Temperely SM, Burrow CR, Kelly TJ, Hay RT (1991) Identification of two distinct regions within the adenovirus minimal origin of replication that are required for adenovirus type 4 DNA replication in vitro. J Virol 65: 5037–5044Google Scholar
  96. Tucker PA, Tsernoglou D, Tucker AD, Coenjaerts FEJ, Leenders H, Van der Vliet PC (1994) X-Ray crystal structure of the 39KDa C-terminal adenovirus DNA binding protein. EMBO J 13: 2994–3002PubMedGoogle Scholar
  97. Van Bergen BGM, Van der Ley PA, Van Driel W, Van Mansfeld ADM, Van der Vliet PC (1983) Replication of origin containing adenovirus DNA fragments that do not carry the terminal protein. Nucleic Acids Res 11: 1975–1989PubMedGoogle Scholar
  98. Van der Vliet PC (1990) Adenovirus DNA replication in vitro. In: Straus P, Wilson SH (eds) The eukaryotic nucleus. Telford, CaldwellGoogle Scholar
  99. Van der Vliet PC, Levine AJ (1973) DNA binding proteins specific for cells infected by adenovirus Nature New Biol 246: 170–174PubMedGoogle Scholar
  100. Van der Vliet PC, Sussenbach JS (1975) An adenovirus type 5 gene function required for initiation of viral DNA replication. Virology 67: 415–426PubMedGoogle Scholar
  101. Van der Vliet PC, Zandberg J, Jansz HS (1977) Evidence for the function of the adenovirus DNA binding protein in initiation of DNA synthesis as well as in elongation on nascent DNA chains. Virology 80: 98–110PubMedGoogle Scholar
  102. Verrijzer CP, Kal AJ, Van der Vliet PC (1990) The DNA binding domain (POU domain) of transcription factor Oct-1 suffices for stimulation of DNA replication. EMBO J 9: 1883–1888PubMedGoogle Scholar
  103. Verrijzer CP, Van Oosterhout JAW, Van Weperen WW, Van der Vliet PC (1991) POU Proteins bend DNA via the POU-specific domain. EMBO J 10: 3007–3014PubMedGoogle Scholar
  104. Verrijzer CP, Van Oosterhout JAW, Van der Vliet PC (1992) The Oct-1 POU domain mediates interactions between Oct-1 and other POU proteins. Mol Cell Biol 12: 542–551PubMedGoogle Scholar
  105. Vos HL, van der Lee FM, Reemst AMCB, van Loon AE, Sussenbach JS (1988) The genes encoding the DNA binding protein and the 23 K protease of adenovirus types 40 and 41. Virology 163: 1–10PubMedGoogle Scholar
  106. Watson CJ, Hay RT (1990) Expression of adenovirus type 2 DNA polymerase in insect cells infected with a recombinant baculovirus. Nucleic Acids Res 18: 1167–1173PubMedGoogle Scholar
  107. Weber J (1990) The adenovirus proteinases. Semin Virol 1: 379–384Google Scholar
  108. Webster A, Russell S, Talbot P, Russell WC, Kemp GD (1989) Characterisation of the adenovirus protease: substrate specificity J Gen Virol 70: 3225–3234PubMedGoogle Scholar
  109. Webster A, Hay RT, Kemp G (1993) The adenovirus protease is activated by a virus-coded disulphide-linked peptide. Cell 72: 97–104PubMedGoogle Scholar
  110. Webster A, Leith I, Hay RT (1994) Activation of the adenovirus coded protease and processing of the preterminal protein. J Virol (in press)Google Scholar
  111. Wides RJ, Challberg MD, Rawlins DR, Kelly TJ (1987) Adenovirus origin of replication: sequence requirements for replication in vitro Mol Cell Biol 7: 864–874PubMedGoogle Scholar
  112. Zijderveld DC, Van der Vliet PC (1994) Helix-destablizing properties of the adenovirus DNA-binding protein. J Virol 68: 1158–1164PubMedGoogle Scholar
  113. Zijderveld DC, Stuiver MH, Van der Vliet PC (1993) The adenovirus DNA binding protein enhances intermolecular renaturation but inhibits intramolecular DNA renaturation. Nucleic Acids Res 21: 641–647Google Scholar

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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  1. 1.Irvine Building, School of Biological and Medical SciencesUniversity of St. AndrewsSt. AndrewsScotland, UK

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