Abortive Adenovirus Infection and Host Range Determinants

  • L. A. Lucher
Part of the Current Topics in 199/I Microbiology and Immunology book series (CT MICROBIOLOGY, volume 199/1)

Abstract

The host range of a virus constitutes at one level the distribution of host organisms that it infects and at another level the tissues in that host that are targeted by the virus. Host range is determined by properties of both the virus and the potential host cell, due to the obligate parasitic nature of viruses. The expression of cell surface receptors for virus strongly correlates with susceptibility of the cell to infection, and cells that do not allow virus to bind are necessarily resistant. Thus host range is initially determined by the presence or absence of the appropriate interaction between extracellular host range determinants that are the virus attachment protein and the host receptor. Broad host range viruses generally bind to common molecules on the cell surface; for example, influenza binds to sialic acid-containing carbohydrates on cellular glycoproteins or glycolipids. Narrow host range viruses typically bind with high affinity to a specific protein, as exemplified by the binding of rhinovirus, poliovirus, and human immunodeficiency virus (HIV) to specific members of the human immunoglobulin super family. Cell surface interactions are not the only determinants of host range, however. Cells that support all steps in multiplication of a virus are termed permissive (with maximum virus yields) or semipermissive (with less than maximum virus yields). Nonpermissive cells allow virus to bind but do not allow complete virus multiplication, and the subsequent abortive infection is caused by the block of one or more multiplication steps at the intracellular level.

Keywords

Influenza Meningitis Chloramphenicol Encephalitis Kelly 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • L. A. Lucher
    • 1
  1. 1.Department of Biological SciencesIllinois State, UniversityNormalUSA

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