Structure and Mechanism of DNA Gyrase

  • D. B. Wigley
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 9)


DNA gyrase is a type II DNA topoisomerase found in bacteria. Since its discovery in 1976 (Geliert et al. 1976), it has been the focus of a great deal of research, from both mechanistic and medical viewpoints, and it is the purpose of this chapter to address the first of these two areas.


Negative Supercoils Adjacent Subunit Ribose Sugar Strand Passage Supercoiling Activity 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • D. B. Wigley
    • 1
  1. 1.Laboratory of Molecular Biophysics, Rex Richards BuildingUniversity of OxfordOxfordUK

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