Repressor Activator Protein 1 and Its Ligands: Organising Chromatin Domains
DNA binding proteins are generally classified as either enzymes, regulatory factors, or structural components of chromatin. The distinction between these groups is not always strict, however, since enzymes (such as DNA topoisomerase II) may also play a structural role in organising chromosomes, and structural proteins (such as histones) can clearly assist in the regulation of gene expression. In the following pages, we review evidence suggesting that the abundant nuclear factor Repressor Activator Protein 1 (RAP1) of budding yeast is both a regulatory factor and a structural element, playing essential roles in both the proper control of gene expression and the maintenance of chromosomal integrity.
KeywordsTelomere Length Origin Recognition Complex Mating Type Gene Upstream Binding Factor Telomeric Cluster
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