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Microtubules, Tau Protein,and Paired Helical Filaments in Alzheimer’s Disease

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The Cytoskeleton

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Abstract

The pathology of Alzheimer’s disease (AD) can be recognized by two types of protein deposits, the amyloid plaques and the neurofibrillary deposits (tangles, neuropil threads). The latter are composed largely of paired helical filaments which are in turn made up mainly of an insoluble form of the microtubule-associated protein tau (Brion et al. 1985). The neurofibrillary deposits are particularly useful in defining the stages of AD progression because they proceed with a well-defined spatial and temporal pattern, starting with the transentorhinal region (stage 1) until eventually the frontal and temporal cortex are affected (stage 6; Braak and Braak 1991; Braak et al. 1994). Only the last three stages are clinically recognizable as AD, while the first three are not noticeable as such. This illustrates the problem in developing a cure or preventing the beginnings of the disease (for review see Braak and Braak 1994).

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  1. Max-Planck-Unit for Structural Molecular Biology, c/o DESY, Notkestrasse 85, D-22603, Hamburg, Germany

    E.-M. Mandelkow

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  1. E. Mandelkow
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  2. J. Biernat
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  3. B. Lichtenberg-Kraag
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  4. G. Drewes
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Editors and Affiliations

  1. Zoologisches Institut Abteilung Zellbiologie, Technische Universität Braunschweig, Spielmannstr.7, D-38092, Braunschweig, Germany

    B. M. Jockusch

  2. AG für strukturelle Molekularbiologie, Max-Planck-Gesellschaft, Notkestr. 85, D-22607, Hamburg, Germany

    E. Mandelkow

  3. Max-Plank-Institut für Biophysikalische Chemie, Am Faßberg, D-37018, Göttingen, Germany

    K. Weber

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Mandelkow, E. et al. (1995). Microtubules, Tau Protein,and Paired Helical Filaments in Alzheimer’s Disease. In: Jockusch, B.M., Mandelkow, E., Weber, K. (eds) The Cytoskeleton. Colloquium der Gesellschaft für Biologische Chemie 14.–16. April 1994 in Mosbach/Baden, vol 45. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79482-7_16

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