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Möglichkeiten einer Immuno- und Zytokintherapie beim metastasierenden Melanom

  • Conference paper
Operative Dermatologie

Part of the book series: Fortschritte der operativen und onkologischen Dermatologie ((OP.DERMATOLOGIE,volume 9))

  • 34 Accesses

Zusammenfassung

Es werden neue Antitumorstrategien dargestellt, welche sich z. T. schon in der klinischen Testung befinden. Hierzu gehören: 1. Die aktive Immunisierung mit Tumorlysaten oder mit virusinfizierten Tumorzellen; 2. Die Therapie mit murinen monoklonalen Antikörpern (MAk), die gegen tumorassoziierte Moleküle gerichtet sind; 3. Behandlung mit Zytokinen wie Inter-leukin-2 (I1-2), Tumornekrosefaktor alpha (TNF-α), die entweder direkt oder über zytotoxi-sche T-Zellen auf den Tumor einwirken; 4. Behandlung mit extrakorporal lymphokinaktivier-ten Killerzellen (LAK) oder mit expandierten tumorinfiltrierenden Lymphozyten (TIL); 5. Behandlung mit molekularbiologisch veränderten, transfizierten Zellen.

Zum einen handelt es sich um eine Immunisierung mit Melanomzellen, die mit dem I1-2 Gen transfiziert wurden, zum anderen um eine Reinfusion von mit dem TNF-α Gen transfizierten TIL. Im ersteren Fall erwartet man durch die vermehrte I1-2 Produktion eine gesteigerte Aktivität von gegen den Tumor gerichteten Killerzellen, im zweiten Fall eine gezieltte TNF-α-Freisetzung am Tumor.

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Authors
  1. M. Roux
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  2. G. Mahrle
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Editors and Affiliations

  1. Abt. Dermatochirurgie, Universitätsklinikum der Medizinischen Fakultät, der Humboldt-Universität Berlin, Schumannstraße 20-21, D-10117, Berlin, Deutschland

    Helmut Winter  & K.-P. Bellmann  & 

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© 1995 Springer-Verlag Berlin Heidelberg

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Roux, M., Mahrle, G. (1995). Möglichkeiten einer Immuno- und Zytokintherapie beim metastasierenden Melanom. In: Winter, H., Bellmann, KP. (eds) Operative Dermatologie. Fortschritte der operativen und onkologischen Dermatologie, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79468-1_11

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  • DOI: https://doi.org/10.1007/978-3-642-79468-1_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79469-8

  • Online ISBN: 978-3-642-79468-1

  • eBook Packages: Springer Book Archive

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